Projects funded by the NCN

Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

Call: SONATA BIS 4 , Panel: ST5

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Multicommutated bioanalytical systems for kinetic studies and enzyme activity assays

Call: OPUS 7 , Panel: ST4

Principal investigator: prof. Robert Koncki

Uniwersytet Warszawski, Wydział Chemii

Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Marcin Ziemniak

Uniwersytet Warszawski, Wydział Fizyki

The impact of P450 and UGT isoenzyme overexpression on cellular response induced by antitumor acridinone derivatives. Th...

Call: OPUS 5 , Panel: NZ3

Principal investigator: prof. Zofia Mazerska

Politechnika Gdańska, Wydział Chemiczny

Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Artur Mucha

Politechnika Wrocławska, Wydział Chemiczny

Designing mRNA transcripts resistant to enzymatic cap hydrolysis applicable for anti-cancer vaccines; multiplexed bioche...

Call: MAESTRO 4 , Panel: NZ1

Principal investigator: prof. Edward Darżynkiewicz

Uniwersytet Warszawski, Centrum Nowych Technologii

Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

Call: SONATA 18 , Panel: NZ6

Principal investigator: dr Wioletta Rut

Politechnika Wrocławska

Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Kinga Czarnota-Łydka

Uniwersytet Jagielloński, Collegium Medicum

Two-component preparations in the treatment of infections caused by pathogenic microorganisms

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Szałapata

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Research on the influence of medicines of the angiotensin-converting enzyme inhibitors (ACEI) group on the choroidal and...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Jowita Zwolska

Uniwersytet Przyrodniczy w Lublinie, Wydział Medycyny Weterynaryjnej

Metabolic stability and inhibition of P450 enzymes in combination with chemometric techniques as a tool for selection of...

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Tomasz Bączek

Gdański Uniwersytet Medyczny, Wydział Farmcautyczny z Oddziałem Medycyny Laboratoryjnej

Design of high selective and safe juvenile hormone epoxide hydrolases inhibitors targeting selected pests based on the c...

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Artur Góra

Politechnika Śląska, Centrum Biotechnologii

Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Tomasz Wróbel

Uniwersytet Medyczny w Lublinie

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

Call: HARMONIA 1 , Panel: NZ1

Principal investigator: prof. Barbara Tudek

Instytut Biochemii i Biofizyki PAN

Dietary polyphenols as thyroid peroxidase (TPO) modulators with multidirectional biological activity - a combined in vit...

Call: OPUS 17 , Panel: NZ9

Principal investigator: prof. Urszula Gawlik-Dziki

Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii

Novel, rationally designed modulators of glycosomal import of enzymes in Trypanosoma parasites

Call: OPUS 16 , Panel: NZ7

Principal investigator: dr hab. Maciej Dawidowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Characterization of hydrolysates and peptides derived from oat kernels proteins in the context of their activity in dise...

Call: PRELUDIUM 16 , Panel: NZ9

Principal investigator: dr Monika Pliszka

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Nauki o Żywności

Search for structure-antimicrobial activity correlation for selected boraheterocycles

Call: OPUS 16 , Panel: ST5

Principal investigator: prof. Sergiusz Luliński

Politechnika Warszawska, Wydział Chemiczny

Inhibition of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa by targeting the enzyme dynamics

Call: SONATA BIS 8 , Panel: NZ1

Principal investigator: dr hab. Krzysztof Brzeziński

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

Call: OPUS 15 , Panel: NZ6

Principal investigator: dr hab. Marcin Sieńczyk

Politechnika Wrocławska

Molecular origins of mechanisms governing biological functions of enzymes with buried actives sites: substrate inhibitio...

Call: SONATA BIS 7 , Panel: NZ1

Principal investigator: dr hab. Jan Brezovsky

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Aminophosphonates bearing fluorine atoms as inhibitors odf aminopeptideses and their potential application for determina...

Call: HARMONIA 9 , Panel: ST5

Principal investigator: prof. Paweł Kafarski

Politechnika Wrocławska

Biomedical materials modification by proteolytic enzymes inhibitors

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Anna Jarosz-Wilkołazka

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Structural studies on inhibition mechanisms of enzymes belonging to USP family, which remove ubiquitin from eukaryotic p...

Call: SONATINA 1 , Panel: NZ1

Principal investigator: dr Marcin Ziemniak

Uniwersytet Warszawski, Wydział Chemii

Synthesis of 2-phosphonocarboxylates as potential covalent inhibitors of Rab geranylgeranyl transferase

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Joanna Małolepsza

Politechnika Łódzka, Wydział Chemiczny

The influence of simultaneous inhibition of endocannabinoid degrading enzymes FAAH and MAGL by JZL195 on the cardiovascu...

Call: PRELUDIUM 11 , Panel: NZ7

Principal investigator: Marek Toczek

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Development of method based on fluorescence polarization for high affinity ligand searching toward m7G nucleotide bindin...

Call: PRELUDIUM 11 , Panel: ST4

Principal investigator: Anna Wojtczak

Uniwersytet Warszawski, Wydział Fizyki

Structure and function characterization of newly discovered unique inhibitors of proteases

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Impact of the engineered mono-dispersed Fe3O4@SiO2 nanoparticles on a fungal enzyme inhibition in vitro

Call: PRELUDIUM 9 , Panel: NZ7

Principal investigator: Ahmet Kertmen

Politechnika Gdańska, Wydział Chemiczny