Projects funded by the NCN

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34 projects found matching your search criteria :

  1. Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

    Call: SONATA BIS 4 , Panel: ST5

    Principal investigator: dr hab. Katarzyna Błażewska

    Politechnika Łódzka, Wydział Chemiczny

  2. Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

    Call: PRELUDIUM 1 , Panel: NZ1

    Principal investigator: Marcin Ziemniak

    Uniwersytet Warszawski, Wydział Fizyki

  3. Multicommutated bioanalytical systems for kinetic studies and enzyme activity assays

    Call: OPUS 7 , Panel: ST4

    Principal investigator: prof. Robert Koncki

    Uniwersytet Warszawski, Wydział Chemii

  4. The impact of P450 and UGT isoenzyme overexpression on cellular response induced by antitumor acridinone derivatives. Th...

    Call: OPUS 5 , Panel: NZ3

    Principal investigator: prof. Zofia Mazerska

    Politechnika Gdańska, Wydział Chemiczny

  5. Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Artur Mucha

    Politechnika Wrocławska, Wydział Chemiczny

  6. Designing mRNA transcripts resistant to enzymatic cap hydrolysis applicable for anti-cancer vaccines; multiplexed bioche...

    Call: MAESTRO 4 , Panel: NZ1

    Principal investigator: prof. Edward Darżynkiewicz

    Uniwersytet Warszawski, Centrum Nowych Technologii

  7. Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Magdalena Wujak

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  8. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  9. New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr Edyta Dyguda-Kazimierowicz

    Politechnika Wrocławska

  10. Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

    Call: SONATA 18 , Panel: NZ6

    Principal investigator: dr Wioletta Rut

    Politechnika Wrocławska

  11. Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Kinga Czarnota-Łydka

    Uniwersytet Jagielloński, Collegium Medicum

  12. Two-component preparations in the treatment of infections caused by pathogenic microorganisms

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Katarzyna Szałapata

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

  13. Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  14. Metabolic stability and inhibition of P450 enzymes in combination with chemometric techniques as a tool for selection of...

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: prof. Tomasz Bączek

    Gdański Uniwersytet Medyczny, Wydział Farmcautyczny z Oddziałem Medycyny Laboratoryjnej

  15. Research on the influence of medicines of the angiotensin-converting enzyme inhibitors (ACEI) group on the choroidal and...

    Call: PRELUDIUM 20 , Panel: NZ4

    Principal investigator: Jowita Zwolska

    Uniwersytet Przyrodniczy w Lublinie, Wydział Medycyny Weterynaryjnej

  16. Design of high selective and safe juvenile hormone epoxide hydrolases inhibitors targeting selected pests based on the c...

    Call: OPUS 20 , Panel: ST4

    Principal investigator: dr hab. Artur Góra

    Politechnika Śląska, Centrum Biotechnologii

  17. Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: dr Tomasz Wróbel

    Uniwersytet Medyczny w Lublinie

  18. Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

    Call: OPUS 19 , Panel: NZ1

    Principal investigator: prof. Mariusz Jaskólski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  19. Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

    Call: HARMONIA 1 , Panel: NZ1

    Principal investigator: prof. Barbara Tudek

    Instytut Biochemii i Biofizyki PAN

  20. Dietary polyphenols as thyroid peroxidase (TPO) modulators with multidirectional biological activity - a combined in vit...

    Call: OPUS 17 , Panel: NZ9

    Principal investigator: prof. Urszula Gawlik-Dziki

    Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii

  21. Novel, rationally designed modulators of glycosomal import of enzymes in Trypanosoma parasites

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: dr hab. Maciej Dawidowski

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

  22. Characterization of hydrolysates and peptides derived from oat kernels proteins in the context of their activity in dise...

    Call: PRELUDIUM 16 , Panel: NZ9

    Principal investigator: dr Monika Pliszka

    Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Nauki o Żywności

  23. Search for structure-antimicrobial activity correlation for selected boraheterocycles

    Call: OPUS 16 , Panel: ST5

    Principal investigator: prof. Sergiusz Luliński

    Politechnika Warszawska, Wydział Chemiczny

  24. Inhibition of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa by targeting the enzyme dynamics

    Call: SONATA BIS 8 , Panel: NZ1

    Principal investigator: dr hab. Krzysztof Brzeziński

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  25. CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

    Call: OPUS 15 , Panel: NZ6

    Principal investigator: dr hab. Marcin Sieńczyk

    Politechnika Wrocławska

  26. Molecular origins of mechanisms governing biological functions of enzymes with buried actives sites: substrate inhibitio...

    Call: SONATA BIS 7 , Panel: NZ1

    Principal investigator: dr hab. Jan Brezovsky

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  27. Aminophosphonates bearing fluorine atoms as inhibitors odf aminopeptideses and their potential application for determina...

    Call: HARMONIA 9 , Panel: ST5

    Principal investigator: prof. Paweł Kafarski

    Politechnika Wrocławska

  28. Biomedical materials modification by proteolytic enzymes inhibitors

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: dr hab. Anna Jarosz-Wilkołazka

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

  29. Structural studies on inhibition mechanisms of enzymes belonging to USP family, which remove ubiquitin from eukaryotic p...

    Call: SONATINA 1 , Panel: NZ1

    Principal investigator: dr Marcin Ziemniak

    Uniwersytet Warszawski, Wydział Chemii

  30. Synthesis of 2-phosphonocarboxylates as potential covalent inhibitors of Rab geranylgeranyl transferase

    Call: PRELUDIUM 12 , Panel: ST5

    Principal investigator: Joanna Małolepsza

    Politechnika Łódzka, Wydział Chemiczny

  31. The influence of simultaneous inhibition of endocannabinoid degrading enzymes FAAH and MAGL by JZL195 on the cardiovascu...

    Call: PRELUDIUM 11 , Panel: NZ7

    Principal investigator: Marek Toczek

    Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  32. Development of method based on fluorescence polarization for high affinity ligand searching toward m7G nucleotide bindin...

    Call: PRELUDIUM 11 , Panel: ST4

    Principal investigator: Anna Wojtczak

    Uniwersytet Warszawski, Wydział Fizyki

  33. Structure and function characterization of newly discovered unique inhibitors of proteases

    Call: OPUS 11 , Panel: NZ1

    Principal investigator: prof. Jan Potempa

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  34. Impact of the engineered mono-dispersed Fe3O4@SiO2 nanoparticles on a fungal enzyme inhibition in vitro

    Call: PRELUDIUM 9 , Panel: NZ7

    Principal investigator: Ahmet Kertmen

    Politechnika Gdańska, Wydział Chemiczny

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