Projects funded by the NCN

Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Agata Elżbieta Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Novel peptide inhibitors of dipeptidyl peptidase IV (DPP IV) as novel approach for diabetes type 2 and inflammatory bowe...

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Maciej Stanisław Sałaga

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Conjugates of prion protein with dendrimers as inhibitors of Abeta peptide amyloidogenesis and cytotoxicity of potential...

Call: HARMONIA 5 , Panel: NZ4

Principal investigator: dr hab. Krzysztof Nieznański

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

Call: OPUS 1 , Panel: ST5

Principal investigator: dr Marek Józef Łuczkowski

Uniwersytet Wrocławski, Wydział Chemii

Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Artur Jacek Mucha

Politechnika Wrocławska, Wydział Chemiczny

Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Monika Katarzyna Łęgowska

Uniwersytet Gdański, Wydział Chemii

Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Izabela Małuch

Uniwersytet Gdański, Wydział Chemii

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

Call: PRELUDIUM 2 , Panel: NZ5

Principal investigator: Marta Sosnowska

Uniwersytet Gdański, Wydział Chemii

Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Aleksandra Dorota Helbik-Maciejewska

Uniwersytet Gdański

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Alicja Potok

Uniwersytet Wrocławski, Wydział Chemii

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Maciej Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Identification of key structural elements of immunomodulatory proteins - inhibitors of antigenic peptide transporter TAP...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Natalia Anna Karska

Uniwersytet Gdański, Wydział Chemii

SELECTIVE REGULATION OF RAB GTPASES BY TARGETING PROTEIN-PROTEIN INTERACTIONS BETWEEN RABS AND REGULATORY PROTEINS

Call: PRELUDIUM BIS 3 , Panel: ST4

Principal investigator: dr hab. Katarzyna Magdalena Błażewska

Politechnika Łódzka, Wydział Chemiczny

Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Carlo Vascotto

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

Call: OPUS 21 , Panel: NZ1

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Blocking HVEM/LIGHT interactions using peptides - an innovative approach to immunosuppression

Call: PRELUDIUM BIS 2 , Panel: ST4

Principal investigator: dr hab. Adam Kazimierz Sieradzan

Uniwersytet Gdański, Wydział Chemii

Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Ewa Maria Surmiak

Uniwersytet Jagielloński, Wydział Chemii

Effects of proteasome inhibition on mitochondrial homeostasis.

Call: OPUS 17 , Panel: NZ5

Principal investigator: prof. Agnieszka Małgorzata Chacińska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Characterization of hydrolysates and peptides derived from oat kernels proteins in the context of their activity in dise...

Call: PRELUDIUM 16 , Panel: NZ9

Principal investigator: dr Monika Anna Pliszka

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Nauki o Żywności

De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Łukasz Berlicki

Politechnika Wrocławska, Wydział Chemiczny

Proteins of dry-cured pork loins with the addition of a probiotic bacterial strain as a potential source od peptides wit...

Call: PRELUDIUM 15 , Panel: NZ9

Principal investigator: dr Paulina Maria Kęska

Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii

Investigation of the effect of thiol group and urea bond on the peptidomimetics' affinity to receptors associated with a...

Call: PRELUDIUM 14 , Panel: NZ7

Principal investigator: dr Anna Katarzyna Puszko

Uniwersytet Warszawski, Wydział Chemii

Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Marta Marcelina Spodzieja

Uniwersytet Gdański, Wydział Chemii

SLPI-dependent cutaneous antimicrobial and antiviral immunity.

Call: OPUS 13 , Panel: NZ6

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Inhibitors, protein aggregation and carbon nanotube

Call: OPUS 1 , Panel: NZ1

Principal investigator: dr hab. Mai Suan Li

Instytut Fizyki Polskiej Akademii Nauk

Multifunctional inhibitors of beta-secretase with anti-aggregating properties of neurotoxic peptides - beta-amyloid and ...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Barbara Antonina Malawska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny