Projects funded by the NCN

Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

Call: SONATA BIS 4 , Panel: ST5

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Marcin Ziemniak

Uniwersytet Warszawski, Wydział Fizyki

Multicommutated bioanalytical systems for kinetic studies and enzyme activity assays

Call: OPUS 7 , Panel: ST4

Principal investigator: prof. Robert Koncki

Uniwersytet Warszawski, Wydział Chemii

Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

Call: SONATA BIS 3 , Panel: NZ5

Principal investigator: prof. Dominika Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Artur Mucha

Politechnika Wrocławska, Wydział Chemiczny

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr Edyta Dyguda-Kazimierowicz

Politechnika Wrocławska

Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

Call: SONATA 18 , Panel: NZ6

Principal investigator: dr Wioletta Rut

Politechnika Wrocławska

Two-component preparations in the treatment of infections caused by pathogenic microorganisms

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Szałapata

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Research on the influence of medicines of the angiotensin-converting enzyme inhibitors (ACEI) group on the choroidal and...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Jowita Zwolska

Uniwersytet Przyrodniczy w Lublinie, Wydział Medycyny Weterynaryjnej

Design of high selective and safe juvenile hormone epoxide hydrolases inhibitors targeting selected pests based on the c...

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Artur Góra

Politechnika Śląska, Centrum Biotechnologii

Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Tomasz Wróbel

Uniwersytet Medyczny w Lublinie

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

Call: HARMONIA 1 , Panel: NZ1

Principal investigator: prof. Barbara Tudek

Instytut Biochemii i Biofizyki PAN

Novel, rationally designed modulators of glycosomal import of enzymes in Trypanosoma parasites

Call: OPUS 16 , Panel: NZ7

Principal investigator: dr hab. Maciej Dawidowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Characterization of hydrolysates and peptides derived from oat kernels proteins in the context of their activity in dise...

Call: PRELUDIUM 16 , Panel: NZ9

Principal investigator: dr Monika Pliszka

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Nauki o Żywności

Search for structure-antimicrobial activity correlation for selected boraheterocycles

Call: OPUS 16 , Panel: ST5

Principal investigator: prof. Sergiusz Luliński

Politechnika Warszawska, Wydział Chemiczny

CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

Call: OPUS 15 , Panel: NZ6

Principal investigator: dr hab. Marcin Sieńczyk

Politechnika Wrocławska

Aminophosphonates bearing fluorine atoms as inhibitors odf aminopeptideses and their potential application for determina...

Call: HARMONIA 9 , Panel: ST5

Principal investigator: prof. Paweł Kafarski

Politechnika Wrocławska

Biomedical materials modification by proteolytic enzymes inhibitors

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Anna Jarosz-Wilkołazka

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Synthesis of 2-phosphonocarboxylates as potential covalent inhibitors of Rab geranylgeranyl transferase

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Joanna Małolepsza

Politechnika Łódzka, Wydział Chemiczny

Development of method based on fluorescence polarization for high affinity ligand searching toward m7G nucleotide bindin...

Call: PRELUDIUM 11 , Panel: ST4

Principal investigator: Anna Wojtczak

Uniwersytet Warszawski, Wydział Fizyki

Structure and function characterization of newly discovered unique inhibitors of proteases

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii