Projects funded by the NCN

The role of glia cells in the mechanism of therapeutic action of ketogenic diet.

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Zuzanna Setkowicz

Uniwersytet Jagielloński, Wydział Biologii

Comprehensive analysis of the therapeutic potential of oligonucleotides for the treatment of polyglutamine diseases

Call: SONATA 9 , Panel: NZ5

Principal investigator: dr hab. Agnieszka Fiszer

Instytut Chemii Bioorganicznej PAN

Structural modifications of bacterial endotoxins (lipopolysaccharides) of significant importance to future antibacterial...

Call: OPUS 8 , Panel: NZ6

Principal investigator: dr hab. Jolanta Katarzyna Łukasiewicz

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Identification and structural characterization of the primordial cytotoxic conformers of the amyloidogenic cascade: Idea...

Call: UNISONO , Panel: NZ1

Principal investigator: prof. Marek Cieplak

Instytut Fizyki PAN

DNA repair pathways contributing to resistance to photodynamic therapy and as possible theraupeutic targets

Call: OPUS 8 , Panel: NZ5

Principal investigator: dr hab. Elżbieta Speina

Instytut Biochemii i Biofizyki PAN

The evaluation of influence of genes encoding oxytocin (OXT), dopamine (D) and arginine vasopressin (AVP) precursors pro...

Call: OPUS 8 , Panel: HS6

Principal investigator: dr hab. Katarzyna Kucharska

Instytut Psychiatrii i Neurologii

Evaluation of an influence of interaction between clopidogrel and statins possessing different pharmacokinetic propertie...

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr Marta Katarzyna Karaźniewicz-Łada

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Evaluation of therapeutic efficacy of selected azaphenothiazines and studies on the mechanism of the immunosuppressive a...

Call: OPUS 8 , Panel: NZ7

Principal investigator: prof. Michał Zimecki

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Engineering of intelligent inhalable therapeutics with the capacity for guided accumulation and triggered release of act...

Call: HARMONIA 6 , Panel: ST5

Principal investigator: prof. Elżbieta Pamuła

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

Role of the complement system in tumorigenesis and therapeutic approaches.

Call: SONATA BIS 4 , Panel: NZ6

Principal investigator: dr hab. Marcin Okrój

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Research on human eosinophils as a potential therapeutic target.

Call: PRELUDIUM 7 , Panel: NZ7

Principal investigator: Marek Rafał Grosicki

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Analysis of relations on the level of metabolome, miRNome, and transcriptome of human renal cancer: towards identificati...

Call: OPUS 7 , Panel: NZ5

Principal investigator: dr hab. Agnieszka Piekiełko-Witkowska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Cancer stem cells signaling pathways as a therapeutic terget in ovarian cancer chemotherapy

Call: OPUS 7 , Panel: NZ5

Principal investigator: prof. Maciej Zabel

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Research of mechanisms of antidepressant action of group II and III mGlu receptor ligands and their role in inducing rap...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii PAN

GPR18 orphan receptor. Search for the tools to investigate GPR18 as potential therapeutic target

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Endogenous enkephalinase inhibitors and their novel synthetic analogs as potential new therapeutics for the treatment of...

Call: OPUS 6 , Panel: NZ7

Principal investigator: dr hab. Jakub Jerzy Fichna

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Influence of AKT signaling pathway on CD20 expression and antitumor activity of therapeutic monoclonal antibodies.

Call: OPUS 6 , Panel: NZ5

Principal investigator: dr Beata Pyrzyńska

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Motor thalamic nuclei as a potential therapeutic target for adenosine in parkinsonian and essential tremor; behavioural,...

Call: OPUS 6 , Panel: NZ4

Principal investigator: dr hab. Jadwiga Wardas

Instytut Farmakologii PAN

Project evaluation of diagnostic, treatment and costs in patients with heart failure among randomly selected outpatient ...

Call: OPUS 1 , Panel: NZ7

Principal investigator: prof. Tomasz Kazimierz Grodzicki

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Mass transport of therapeutic substance from the homogeneous or multi-phase implant which is its reservoir or formation ...

Call: OPUS 6 , Panel: ST8

Principal investigator: dr hab. Anna Trusek-Hołownia

Politechnika Wrocławska, Wydział Chemiczny

BCL11b - Potential Therapeutic Target in T cell Neoplasms

Call: OPUS 5 , Panel: NZ1

Principal investigator: dr hab. Grzegorz Przybylski

Instytut Genetyki Człowieka PAN

Infective endocarditis - the in vitro biomedical analysis of the potential therapeutic properties of selected phytochemi...

Call: PRELUDIUM 5 , Panel: NZ6

Principal investigator: Bartłomiej Micota

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Innovative biopreparations with therapeutic activity - chemical and enzymatic methods for production of phospholipids co...

Call: SONATA 5 , Panel: NZ9

Principal investigator: dr Anna Gliszczyńska

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Nauk o Żywności

The role of sphingosine-1-phosphate (S1P) receptors signaling in animal model of Parkinson disease. Searching of novel t...

Call: PRELUDIUM 5 , Panel: NZ4

Principal investigator: Joanna Agata Motyl

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Regulation of Expression of Ecto-5'-Nucleotidase - Changes in Pathology and Therapeutic Potential

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr hab. Ryszard Tomasz Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski

Evaluation of peroxiredoxins 1 and 2 along with the thioredoxin-thioredoxin reductase system as new therapeutic targets ...

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Analysis of immungenecity and therapeutic activity of cell cancer vaccines based on cancer stem cells and induced plurip...

Call: OPUS 4 , Panel: NZ6

Principal investigator: prof. Andrzej Mackiewicz

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Synthesis and analysis of potential furin inhibitors in the development of the new therapeutic strategies against viral ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Monika Aleksandra Lewandowska-Goch

Uniwersytet Gdański, Wydział Chemii

Identification of potential therapeutic targets in melanoma stem-like cells

Call: HARMONIA 3 , Panel: NZ2

Principal investigator: prof. Małgorzata Ewa Czyż

Uniwersytet Medyczny w Łodzi, Wydział Lekarski z Oddziałem Stomatologicznym

Identifcation of regulatory effects of bacteriophages with therapeutic potential on mammalian cell functions and immunit...

Call: SONATA BIS 1 , Panel: NZ6

Principal investigator: dr hab. Krystyna Dąbrowska

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Stimulation of endogenous neurogenesis as a novel therapeutic strategy in neonatal hypoxic-ischemic brain injury.

Call: OPUS 3 , Panel: NZ3

Principal investigator: dr Małgorzata Nałęcz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

MicroRNA-dependent regulation of adhesion-related molecules in clear cell renal cell carcinoma: the search for markers o...

Call: OPUS 3 , Panel: NZ5

Principal investigator: dr hab. Agnieszka Piekiełko-Witkowska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Interactions between biologically active phytocompounds present in the fodder and selected therapeuticals used in the th...

Call: SONATA 3 , Panel: NZ9

Principal investigator: dr hab. Marta Mendel

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

New reagents and methods in synthesis of modified nucleotides and their application for preparation biochemical tools an...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Ventilation, gas exchange and cardiac function in relation to intrapleural pressure changes in patients undergoing thera...

Call: OPUS 3 , Panel: NZ5

Principal investigator: prof. Rafał Krenke

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Searching for the molecular mechanisms of the therapeutic use of histamine signal and histamine receptors H1R, H2R and H...

Call: HARMONIA 2 , Panel: NZ6

Principal investigator: prof. Marek Michał Jutel

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarski

PIM kinases as rational therapeutic targets in lymphoid malignancies.

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Targeted Degradation of the MLL Complex in Leukemia: A PROTAC-Based Therapeutic Strategy

Call: SONATINA 9 , Panel: ST5

Principal investigator: dr Natalia Anna Skrzypczak

Fundacja Uniwersytetu im. Adama Mickiewicza

Antibacterial molecules based on bacteriophage proteins and constant antibody fragments with therapeutic potential for t...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Karolina Aleksandra Filik-Matyjaszczyk

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Modulating Neuroplasticity with Psilocybin: Assesment Therapeutic Potential in Treating Fentanyl use disorder

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Ewa Taracha

Instytut Psychiatrii i Neurologii

Identifying early biomarkers and molecular targets for therapeutic intervention in right ventricular dysfunction

Call: OPUS 28 , Panel: NZ5

Principal investigator: prof. Przemysław Błyszczuk

Uniwersytet Jagielloński

Molecular insights into NAD+ metabolism in Huntington's disease: role in pathophysiology and preclinical assessment of t...

Call: OPUS 28 , Panel: NZ5

Principal investigator: dr hab. Marta Urszula Tomczyk

Gdański Uniwersytet Medyczny

Porous bioglass-alginate composite granules as the antibiotic delivery system with therapeutic and regenerative potentia...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Adrian Szewczyk

Gdański Uniwersytet Medyczny

A triple agonist of glucagon, GLP-1, and GIP receptors as a novel therapeutic option for the treatment of heart failure ...

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Marta Katarzyna Oknińska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Selective autophagy-mediated protein degradation as a potential therapeutic strategy for the treatment of inflammatory c...

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Monika Emilia Marcinkowska

Uniwersytet Jagielloński

The H3K27M oncohistone-centred molecular mechanisms as therapeutic targets in pediatric malignant diffuse midline glioma...

Call: SONATA BIS 14 , Panel: NZ3

Principal investigator: dr Katarzyna Leszczyńska

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Exploring DMRTA2 in Glioblastoma: Epigenetic Regulation, Angiogenesis Disruption, and Biomarker Development

Call: SONATA BIS 14 , Panel: NZ3

Principal investigator: dr Marta Magdalena Maleszewska-Bobińska

Uniwersytet Warszawski

Improving the therapeutic potential of cytostatics through the use of abiotic metallacarboranes.

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Michalina Gos

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Development of novel potential therapeutics in inflammatory bowel diseases based on nanoformulations employing senomodul...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Jakub Jerzy Fichna

Uniwersytet Medyczny w Łodzi

New phosphino derivatives of chinolone antibiotics and their complexes with copper (I) and copper (II) ions. Determinati...

Call: OPUS 2 , Panel: ST5

Principal investigator: prof. Małgorzata Janina Jeżowska-Bojczuk

Uniwersytet Wrocławski, Wydział Chemii