Projects funded by the NCN

Molecular mechanisms linking BRAF mutations and the expression of immunoregulatory molecules, galectin-1 and PD-L1 in me...

Call: PRELUDIUM 8 , Panel: NZ5

Principal investigator: Maja Magdalena Wasylecka-Juszczyńska

Instytut Hematologii i Transfuzjologii

Novel insights into inhibition of PD-L1/PD-1 immune checkpoint – discovery and optimization of covalent PD-L1 inhibitors...

Call: SONATA 20 , Panel: ST5

Principal investigator: dr Radosław Dariusz Kitel

Uniwersytet Jagielloński

Controlling the covalent activity of a PD-L1 inhibitors with light

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Wiktor Jan Uzar

Uniwersytet Jagielloński

The role of the immune checkpoints in the pathomechanism of depressive disorders.

Call: OPUS 22 , Panel: NZ6

Principal investigator: prof. Marta Wanda Kubera

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Photoswitchable and chimeric molecules for spatially restricted and endoplasmic reticulum-specific blockade of PD-L1 pro...

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: dr Łukasz Dariusz Skalniak

Uniwersytet Jagielloński, Wydział Chemii

The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Magdalena Maria Żarnik

Uniwersytet Jagielloński, Wydział Chemii

The clinical significance of immunosuppression in ovarian cancer microenvironments

Call: PRELUDIUM 20 , Panel: NZ6

Principal investigator: dr Anna Maria Pawłowska-Łachut

Uniwersytet Medyczny w Lublinie

Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Ewa Maria Surmiak

Uniwersytet Jagielloński, Wydział Chemii

Photodynamic therapy combined with PD-1/PD-L1 blockade immunotherapy: new possibilities for the treatment of immunogenic...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr hab. Janusz Marcin Dąbrowski

Uniwersytet Jagielloński, Wydział Chemii

Structure optimization of the PD-1/PD-L1 inhibitors based on the terphenyl scaffold

Call: PRELUDIUM 19 , Panel: ST4

Principal investigator: dr Damian Muszak

Uniwersytet Jagielloński, Wydział Chemii

Evaluation of the activity of MDM2-p53 antagonist RG7388 in mouse cancer models, alone and in combination with anti-PD-1...

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Aneta Sylwia Nieznańska

Uniwersytet Jagielloński, Wydział Chemii

Development of a three-dimensional in vitro model for studying the mechanisms of immunostimulatory activity of PD-1/PD-L...

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Justyna Natalia Kocik-Król

Uniwersytet Jagielloński, Wydział Chemii

Development of macrocyclic peptide antagonists of the PD-1/PD-L1 pathway. Charcterization of simultaneous administration...

Call: SONATA 14 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Łukasz Berlicki

Politechnika Wrocławska, Wydział Chemiczny

Small-molecule inhibitors for characterization of the interaction between extracellular domains of Programmed Cell Death...

Call: MAESTRO 9 , Panel: ST5

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Strukturalne aspekty oddziaływania ludzkich białek PD-1/PD-L1 oraz niskocząsteczkowe inhibitory tego oddziaływania.

Call: ETIUDA 4 , Panel: NZ1

Principal investigator: Krzysztof Maria Żak

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Synthesis and Struktural Characterization of Small-Molecule Probes for the Programmed Death 1/ Programmed Death Ligand 1...

Call: PRELUDIUM 10 , Panel: ST5

Principal investigator: Katarzyna Agnieszka Guzik

Uniwersytet Jagielloński, Wydział Chemii