Projects funded by the NCN

Lyn tyrosine kinase as regulator of lipopolysaccharide-triggered TLR4 pro-inflammatory signaling

Call: PRELUDIUM 7 , Panel: NZ3

Principal investigator: dr Kinga Borzęcka-Solarz

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Inhibition of p21-Activated Kinase (PAK) as a new molecular target in the treatment of chronic myeloid leukemia (CML)

Call: OPUS 6 , Panel: NZ7

Principal investigator: dr hab. Sylwia Flis

Narodowy Instytut Leków

Mechanism regulating vitamin D analog cooperation with cytostatics and tyrosine kinase inhibitors in non-small cell lung...

Call: PRELUDIUM 5 , Panel: NZ4

Principal investigator: dr Ewa Maj

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

Polymorphic pre-miR-146a and synergistic action of all of its products on NTRK2 gene in Papillary Thyroid Carcinoma

Call: PRELUDIUM 4 , Panel: NZ2

Principal investigator: dr Anna Kubiak

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Zn2+-dependent competition between CD4 and CD8α coreceprtor for Lck tyrosine kinase

Call: SONATA 19 , Panel: NZ1

Principal investigator: dr Anna Kocyła

Uniwersytet Wrocławski, Wydział Biotechnologii

Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr Tomasz Prajsnar

Uniwersytet Jagielloński, Wydział Biologii

Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Krzysztof Domka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

INVADOPODIA IN AXL-DRIVEN CANCER INVASION AND DRUG RESISTANCE

Call: OPUS 25 , Panel: NZ3

Principal investigator: dr Daria Zdżalik-Bielecka

Uniwersytet Warszawski, Wydział Biologii

Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

Call: POLONEZ BIS 3 , Panel: NZ7

Principal investigator: dr hab. Aneta Radziwon-Balicka

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Florczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Mikołaj Czajkowski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

AXL receptor signaling in cancer cell growth and drug resistance

Call: OPUS 20 , Panel: NZ3

Principal investigator: prof. Marta Miączyńska

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

Iron chelators as tyrosine kinase inhibitors - a new strategy for the treatment of glioblastoma multiforme

Call: PRELUDIUM BIS 2 , Panel: NZ5

Principal investigator: dr hab. Anna Mrozek-Wilczkiewicz

Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

A novel approach based on the optimized multidrug combination for glioblastoma treatment.

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Małgorzata Kucińska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Comparative evaluation of effects of tyrosine kinase inhibitors (TKIs) on endothelial function in vivo in mice

Call: PRELUDIUM 17 , Panel: NZ5

Principal investigator: Brygida Marczyk

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Insights into biological activity and mechanism of action of novel styrylquinazoline derivatives as tyrosine kinase inhi...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Katarzyna Malarz

Uniwersytet Śląski w Katowicach, Wydział Matematyki, Fizyki i Chemii

Impact of palmitoylation on the Zn(II)-dependent interaction between CD4 coreceptor and Lck tyrosine kinase.

Call: PRELUDIUM 11 , Panel: NZ1

Principal investigator: Anna Kocyła

Uniwersytet Wrocławski, Wydział Biotechnologii

Analysis of the effectiveness of anticancer activity of tyrosine kinase inhibitors combined with nanoparticles in in vit...

Call: SONATA 11 , Panel: ST4

Principal investigator: dr Natalia Piergies

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego Polskiej Akademii Nauk

Endocytosis of AXL receptor and its role in AXL-mediated signaling.

Call: SONATA 10 , Panel: NZ3

Principal investigator: dr Daria Zdżalik-Bielecka

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

New MOF compounds as degradable nanocontainers of tyrosine kinases inhibitors in novel anti-cancer therapy

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Artur Terzyk

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Protein and gene expression analysis in the course of renal cancer stem-like cells' primary resistance to sorafenib in h...

Call: PRELUDIUM 9 , Panel: NZ5

Principal investigator: Zofia Bielecka

Wojskowy Instytut Medyczny