Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Endocytosis of AXL receptor and its role in AXL-mediated signaling.

2015/19/D/NZ3/03270

Keywords:

endocytosis endosomes AXL GAS6 receptor tyrosine kinases

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Daria Zdżalik-Bielecka 

Number of co-investigators in the project: 3

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 762 929 PLN

Project start date (Y-m-d): 2016-08-19

Project end date (Y-m-d): 2020-08-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion
    Authors:
    Daria Zdżalik-Bielecka, Agata Poświata, Kamila Kozik, Kamil Jastrzębski, Kay Oliver Schink, Marta Brewińska-Olchowik, Katarzyna Piwocka, Harald Stenmark, Marta Miączyńska
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) (rok: 2021, tom: 118, strony: brak), Wydawca: National Academy of Sciences (NAS)
    Status:
    Published
    DOI:
    10.1073/pnas.2024596118 - link to the publication
  2. Bemcentinib and gilteritinib inhibit cell growth and impair the endo-lysosomal and autophagy systems in an AXL-independent manner
    Authors:
    Daria Zdzalik-Bielecka, Kamila Kozik, Agata Poswiata, Kamil Jastrzebski, Marta Jakubik, Marta Miaczynska
    Academic press:
    Molecular Cancer Research (rok: 2021, tom: brak, strony: brak), Wydawca: American Association for Cancer Research (USA)
    Status:
    Published
    DOI:
    10.1158/1541-7786.MCR-21-0444 - link to the publication
  3. GAS6-induced endocytic trafficking of AXL displays a unique pattern associated with sustained AKT activation
    Authors:
    Agata Poświata, Kamila Kozik, Marta Miączyńska, Daria Zdżalik-Bielecka
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2021, tom: brak, strony: brak), Wydawca: Springer Science+Business Media
    Status:
    Submitted
    DOI:
    brak - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy