Projects funded by the NCN

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72 projects found matching your search criteria :

  1. Abeta 4-x peptides as copper binding molecules resistant to chelating drugs, promoting the formation of amyloid oligomer...

    Call: OPUS 8 , Panel: ST5

    Principal investigator: prof. Wojciech Bal

    Instytut Biochemii i Biofizyki PAN

  2. Synthesis and tandem mass spectrometry examination of new ionization tags based on thiazolidinecarboxylic acid and oxazo...

    Call: PRELUDIUM 8 , Panel: ST5

    Principal investigator: Bartosz Setner

    Uniwersytet Wrocławski, Wydział Chemii

  3. Determination of the exact structure of the complex (complexes) of AB1-16 peptide with Pd(II) ions using nuclear magneti...

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: Mariusz Mital

    Instytut Biochemii i Biofizyki PAN

  4. Can Fusobacterium nucleatum adhesion proteins increase prooxidative activity of iron and copper ions?

    Call: OPUS 7 , Panel: ST5

    Principal investigator: dr Kamila Stokowa-Sołtys

    Uniwersytet Wrocławski, Wydział Chemii

  5. Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: Agata Gitlin-Domagalska

    Uniwersytet Gdański, Wydział Chemii

  6. Application of macrocycles formed by substituted trithiocyanuric acid as template for self-assembly of peptide chains

    Call: PRELUDIUM 6 , Panel: ST5

    Principal investigator: dr Marta Cal

    Uniwersytet Wrocławski, Wydział Chemii

  7. Synthesis and structural study of modified porphyrinoids

    Call: PRELUDIUM 6 , Panel: ST5

    Principal investigator: Justyna Śniechowska

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  8. A development of a method of micro-scale synthesis of peptides labelled with stable isotopes for quantitative proteomics

    Call: PRELUDIUM 6 , Panel: ST4

    Principal investigator: Maciej Modzel

    Uniwersytet Wrocławski, Wydział Chemii

  9. Synthesis, biological and biophysical evaluation of mRNA cap-peptide conjugates for targeted delivery of cap analogues t...

    Call: OPUS 6 , Panel: ST5

    Principal investigator: dr hab. Marzena Jankowska-Anyszka

    Uniwersytet Warszawski, Wydział Chemii

  10. Synthesis, physico-chemical and biological studies on macromolecular carriers of antimicrobial peptides

    Call: PRELUDIUM 6 , Panel: NZ7

    Principal investigator: Urszula Piotrowska

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  11. Alpha factor of S. cerevisiae yeast: formation of copper and zinc complexes and their biological activity

    Call: OPUS 5 , Panel: ST5

    Principal investigator: prof. Wojciech Bal

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  12. Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

    Call: OPUS 1 , Panel: ST5

    Principal investigator: dr Marek Łuczkowski

    Uniwersytet Wrocławski, Wydział Chemii

  13. Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: dr Justyna Piekielna-Ciesielska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  14. Synthesis and fragmentation of peptides conjugated with betaine derivatives - a search for isobaric markers for quantita...

    Call: OPUS 5 , Panel: ST4

    Principal investigator: prof. Zbigniew Szewczuk

    Uniwersytet Wrocławski, Wydział Chemii

  15. Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Artur Mucha

    Politechnika Wrocławska, Wydział Chemiczny

  16. Synthetic cysteine peptides as molecular layers for studies of interactions between copper ions and beta-amyloid

    Call: SONATA 4 , Panel: ST4

    Principal investigator: dr Urszula Wawrzyniak

    Politechnika Warszawska, Wydział Chemiczny

  17. Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Monika Łęgowska

    Uniwersytet Gdański, Wydział Chemii

  18. Fluorescent substrates of neutrophil proteinases: design, chemical synthesis , selection by the combinatorial chemistry ...

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Jadwiga Popow - Stellmaszyk

    Uniwersytet Gdański, Wydział Chemii

  19. Synthesis and biological studies of conjugates formed by peptide dendrimers and natural polyphenols and their analogs

    Call: OPUS 4 , Panel: ST5

    Principal investigator: prof. Zofia Lipkowska

    Instytut Chemii Organicznej PAN

  20. Quaternary ammonium salts of cryptando-peptidic conjugates. Synthesis and chemical properties.

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Remigiusz Bąchor

    Uniwersytet Wrocławski, Wydział Chemii

  21. Oxidative modification of amino acid residues in proteins - synthetic studies towards selective detection

    Call: SONATA 4 , Panel: ST5

    Principal investigator: dr Monika Kijewska

    Uniwersytet Wrocławski, Wydział Chemii

  22. Characterization of CD44/p53 signaling involved in the CD44-dependent cancer stem cells: small molecules and peptides, t...

    Call: MAESTRO 3 , Panel: ST5

    Principal investigator: prof. Tadeusz Holak

    Uniwersytet Jagielloński, Wydział Chemii

  23. Helical peptides rich in aminoisobutyric acid residues - synthesis, electrical properties and interactions with model li...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Joanna Juhaniewicz

    Uniwersytet Warszawski, Wydział Chemii

  24. The impact of synthetic modifications of the histidine side chain on coordination properties of analogues of the N-termi...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Izabela Zawisza

    Instytut Biochemii i Biofizyki PAN

  25. A novel strategy for construction of antifungal pro-drugs based on the cell-penetrating peptides

    Call: OPUS 3 , Panel: ST5

    Principal investigator: prof. Sławomir Milewski

    Politechnika Gdańska, Wydział Chemiczny

  26. Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Izabela Małuch

    Uniwersytet Gdański, Wydział Chemii

  27. Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

    Call: PRELUDIUM 2 , Panel: ST5

    Principal investigator: Jolanta Dyniewicz

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  28. Structural and functional characterization of peptidyl prolyl isomerases - universally conserved protein folding catalys...

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: prof. Satish Raina

    Politechnika Gdańska, Wydział Chemiczny

  29. The usage of synthetic peptides mimicking flap region of bacterial ureases for estimation of anti-urease diversity in rh...

    Call: SONATA 2 , Panel: NZ6

    Principal investigator: dr Iwona Konieczna

    Uniwersytet Jana Kochanowskiego w Kielcach, Wydział Matematyczno-Przyrodniczy

  30. Synthesis of deltorphin I and dermorphin analogues modified with alfa-alkyl-beta-azido(amino)alanine in postion 2 or 3.

    Call: PRELUDIUM 2 , Panel: ST5

    Principal investigator: Anika Lasota

    POLITECHNIKA ŁÓDZKA, Politechnika Łódzka, Wydział Chemiczny,

  31. Retro-inverso modification of zinc(II)–GLP-1 receptor agonist complexes – from bioinorganic chemistry to animal studies...

    Call: OPUS 26 , Panel: ST5

    Principal investigator: dr hab. Magdalena Rowińska-Żyrek

    Uniwersytet Wrocławski, Wydział Chemii

  32. Novel receptor materials for the construction of a bioelectronic nose for the rapid and efficient detection of lung canc...

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Wojciech Kamysz

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  33. The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Paulina Potok

    Uniwersytet Wrocławski, Wydział Chemii

  34. Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Piotr Chyży

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  35. Conjugates of peptide nucleic acids with aminoglycosides and fluoroquinolones as a novel strategy to target multi-drug r...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Izabela Siekierska

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  36. Blocking interactions between Rab1b and Rab5 proteins and their negative regulators TBC1D20 and TBC1D17 with synthetic p...

    Call: PRELUDIUM BIS 3 , Panel: NZ1

    Principal investigator: dr hab. Edyta Gendaszewska-Darmach

    Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

  37. Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Sylwia Rodziewicz-Motowidło

    Uniwersytet Gdański, Wydział Chemii

  38. Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

    Call: SONATA 16 , Panel: ST4

    Principal investigator: dr Ewa Surmiak

    Uniwersytet Jagielloński, Wydział Chemii

  39. Application of N-(2-thioethyl)glycine analogues in orthogonal cleavage of peptides from solid support

    Call: PRELUDIUM 18 , Panel: ST4

    Principal investigator: Magdalena Wierzbicka

    Uniwersytet Wrocławski, Wydział Chemii

  40. Novel analogs of human cathelicidin (LL-37) with enhanced resistant to enzymatic degradation. Design chemical synthesis ...

    Call: PRELUDIUM BIS 1 , Panel: ST4

    Principal investigator: prof. Adam Lesner

    Uniwersytet Gdański, Wydział Chemii

  41. MOLECULAR INSIGHTS INTO BIOSYNTHESIS OF PEPTIDE AZOLE ANTIBIOTICS

    Call: SONATA 15 , Panel: NZ1

    Principal investigator: dr Dmitry Gilyarov

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  42. Synthetic self-assembled models of transmembrane proteins

    Call: PRELUDIUM 18 , Panel: ST4

    Principal investigator: Grzegorz Wołczański

    Uniwersytet Wrocławski, Wydział Chemii

  43. Evaluation of characteristic interactions of synthetic peptides derived from HarmOBP7 aldehyde binding site.

    Call: PRELUDIUM 17 , Panel: ST5

    Principal investigator: Tomasz Wasilewski

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  44. Innovative hybrid materials useful in the syntheis of dressings for the treatment of diabetic foot ulcers

    Call: OPUS 16 , Panel: ST8

    Principal investigator: dr hab. Beata Kolesińska

    Politechnika Łódzka, Wydział Chemiczny

  45. Fundamentals of copper exchange kinetics between model peptides and small molecules.

    Call: PRELUDIUM 16 , Panel: ST5

    Principal investigator: Radosław Kotuniak

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  46. De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

    Call: OPUS 16 , Panel: ST5

    Principal investigator: dr hab. Łukasz Berlicki

    Politechnika Wrocławska

  47. Fusion peptides and transmembrane domains of selected enveloped viruses: structure, dynamics and interactions with membr...

    Call: SONATA BIS 8 , Panel: NZ1

    Principal investigator: dr Remigiusz Worch

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  48. Lipid nanoparticles loaded with antibacterial peptides as an alternative treatment for bacterial infections

    Call: PRELUDIUM 15 , Panel: ST5

    Principal investigator: dr Katarzyna Reczyńska-Kolman

    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

  49. Synthesis of new functional cages based on trigonal peptidic building blocks by dynamic covalnt chemistry

    Call: PRELUDIUM 15 , Panel: ST5

    Principal investigator: Marcin Grajda

    Instytut Chemii Organicznej Polskiej Akademii Nauk

  50. Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: prof. Barbara Przewłocka

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

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