Projects funded by the NCN

Nitroxyl's role in the signaling cross-talk between cell death and life during potato leaves' hypersensitive response to...

Call: OPUS 28 , Panel: NZ9

Principal investigator: prof. Magdalena Arasimowicz-Jelonek

Uniwersytet im. Adama Mickiewicza w Poznaniu

Regulation of energy metabolism in the thalamus: molecular mechanisms and behavioral consequences

Call: OPUS 28 , Panel: NZ4

Principal investigator: dr hab. Marta Barbara Wiśniewska

Uniwersytet Warszawski

Modulation of 5-HT7 receptor signaling as common mechanism involved in the long-lasting antidepressant effects of typica...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Barbara Wanda Chruścicka-Smaga

Instytut Farmakologii PAN

Understanding the function of DTX3L ligase in an antiviral response induced by pattern recognition receptors (PRR).

Call: OPUS 27 , Panel: NZ3

Principal investigator: dr hab. Jakub Maciej Siednienko

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

The significance of signalling through the primary cilium in pathological peritoneal remodelling of patients under perit...

Call: OPUS 27 , Panel: NZ3

Principal investigator: dr Edyta Kawka

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

The role of TCF7L2 transcription factor in developing and in adult hippocampal astrocytes

Call: OPUS 27 , Panel: NZ4

Principal investigator: dr Łukasz Mateusz Szewczyk

Uniwersytet Warszawski

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański

Precision double strike against non-small cell lung cancer. Insights into multidirectional therapies and the landscape o...

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Katarzyna Anna Malarz

Politechnika Śląska

Targeting Proteinopathies: Understanding and Mitigating the Effects of Pathogenic Mutations in Cullin-RING Ubiquitin Lig...

Call: OPUS 27 , Panel: NZ3

Principal investigator: dr hab. Wojciech Mieczysław Pokrzywa

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Uncovering the role of oxytocin and relaxin-3 signalling within dentate gyrus in neuronal mechanisms underlying autism s...

Call: PRELUDIUM 23 , Panel: NZ4

Principal investigator: Aleksandra Nogaj

Uniwersytet Jagielloński

Precise targeting of the FGF signaling system by DNA aptamers

Call: WEAVE-UNISONO , Panel: NZ1

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski

Deciphering the importance of the intracellular FGFR1 module for cell fate

Call: OPUS 26 , Panel: NZ1

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski, Wydział Biotechnologii

Nesfatin-1, the new hormone controlling the pig reproductive system: studies of the transcriptome, proteome, metabolome ...

Call: OPUS 26 , Panel: NZ9

Principal investigator: prof. Tadeusz Szczepan Kamiński

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Biologii i Biotechnologii

The influence of ethylene, nitric oxide and generated by the NADPH oxidase reactive oxygen species on the expression of ...

Call: PRELUDIUM 2 , Panel: NZ9

Principal investigator: dr Jagna Chmielowska-Bąk

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

An unexplored face of auxin signaling - the MONOPTEROS MP11ir isoform for an auxin independent gene expression regulatio...

Call: OPUS 26 (LAP) , Panel: NZ1

Principal investigator: dr Barbara Karolina Wójcikowska

UNIWERSYTET ŚLĄSKI, Wydział Nauk Przyrodniczych

The role of Diaph1 signaling in cardiovascular autonomic neuropathy in diabetes

Call: PRELUDIUM 22 , Panel: NZ4

Principal investigator: Bernard Kordas

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Lekarski

Determination of the molecular mechanism of action of TRIM32 E3 ligase in the regulation of adipocytes' function

Call: PRELUDIUM 22 , Panel: NZ4

Principal investigator: Katia Alghoz

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The role of phosphoinositides during phototropin signaling in higher plants.

Call: PRELUDIUM 2 , Panel: NZ3

Principal investigator: Chhavi Aggarwal

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Dinucleoside polyphosphates (NpnN′s) as a component of the molecular mechanism in plant response to environmental stress...

Call: OPUS 24 , Panel: NZ9

Principal investigator: dr hab. Małgorzata Pietrowska-Borek

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

Identification and characterization of the mechanisms governing singlet oxygen-induced chloroplast retrograde signaling ...

Call: POLONEZ BIS 3 , Panel: NZ1

Principal investigator: dr Pawel Brzezowski

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Mitochondrial dynamics and its role in shaping of the mammalian embryonic environment from fertilisation to the first ce...

Call: OPUS 24 , Panel: NZ3

Principal investigator: dr hab. Zofia Eliza Madeja

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

The signalling role of protein S-nitrosylation induced by nitric oxide in resistance of potato leaves to Phytophthora in...

Call: PRELUDIUM 2 , Panel: NZ9

Principal investigator: dr Dariusz Abramowski

Uniwersytet Przyrodniczy w Poznaniu, Wydział Ogrodnictwa i Architektury Krajobrazu

The discovery of multifactorial regulation at epigenetic memory of active gene expression state

Call: SONATA 18 , Panel: NZ2

Principal investigator: dr Paweł Sławomir Mikulski

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

Call: OPUS 24 (LAP) , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński, Collegium Medicum

Circadian signaling functions of the phosphoinositide phosphatase SHIP2

Call: SONATA BIS 12 , Panel: NZ3

Principal investigator: dr Abdelhalim Azzi

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Pancreatic diseases from a new perspective - ion signalling, mitochondria and the TRPA1 channel

Call: SONATA BIS 12 , Panel: NZ3

Principal investigator: dr Paweł Eugeniusz Ferdek

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Proinsulin C-peptide and G protein-coupled receptor 146 (GPR146) – clinical investigation of the impact of their signall...

Call: PRELUDIUM 21 , Panel: NZ4

Principal investigator: Aleksandra Ryk

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Katarzyna Joanna Dziubek

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

The role of aquaporins in the cold-response in the roots of C4 plants: maize (Zea mays L.) and sorghum (Sorghum bicolor)...

Call: OPUS 23 , Panel: NZ9

Principal investigator: dr hab. Anna Bilska-Kos

Instytut Hodowli i Aklimatyzacji Roślin - Państwowy Instytut Badawczy

The role of the unique phosphodiesterase in the regulation of Tannerella forsythia secretion and cell signaling

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Anna Kamila Jacuła

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Extracellular vimentin as a signaling molecule in the pathogenesis of inflammation and central nervous system damage in ...

Call: PRELUDIUM 21 , Panel: NZ6

Principal investigator: Łukasz Jerzy Suprewicz

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

Study of the role of GRHL1 transcription factor in mechanisms of development of skin cancers and in cellular signaling p...

Call: PRELUDIUM 2 , Panel: NZ3

Principal investigator: Michał Krzysztof Mlącki

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The role of symbiotic bacteria in chemical signaling in reptilian host species

Call: SONATA 17 , Panel: NZ8

Principal investigator: dr Alejandro Ibáñez Ricoma

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Impact of the CDK4/6 targeted degradation by PROTACs on immune checkpoint signaling in cancer

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

New strategy for overcoming resistance to chemotherapy of ovarian cancer by modulation of the canonical and non-canonica...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Radosław Januchowski

Uniwersytet Zielonogórski, Collegium Medicum

Development of the knowledge on the role of GPR18 ligands as a microglia-targeted strategy in the regulation of neuroinf...

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Ewelina Barbara Honkisz-Orzechowska

Uniwersytet Jagielloński, Collegium Medicum

Targeting cell surface proteoglycans with high affinity multimeric ligands and their cytotoxic conjugates – towards prec...

Call: OPUS 22 , Panel: NZ1

Principal investigator: dr hab. Łukasz Opaliński

Uniwersytet Wrocławski, Wydział Biotechnologii

Comprehensive phosphoproteomic analysis of NKT cells in the context of the role of phosphorylation mechanisms in progres...

Call: OPUS 22 , Panel: NZ2

Principal investigator: dr hab. Magdalena Łuczak

Instytut Chemii Bioorganicznej PAN

Maternal obesity as a risk factor of autism spectrum disorder in offspring - in search of the role of the gut microbiota...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Dawid Mateusz Gawliński

Instytut Farmakologii PAN

Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Anna Agnieszka Marusiak

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Adaptation of Proteins to Evade Premature Degradation by the Ubiquitin-Proteasome System

Call: SONATA BIS 11 , Panel: NZ1

Principal investigator: dr hab. Wojciech Mieczysław Pokrzywa

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Investigating the role of the focal adhesion kinase and its related signaling pathways in glucocorticoid- and stress-ind...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Michał Józef Wilczkowski

Instytut Farmakologii PAN

In search of the unexplored aspects of ferric heme protein-dependent regulationof nitric oxide signaling in the erythroc...

Call: OPUS 21 , Panel: NZ3

Principal investigator: dr Jakub Stanisław Dybaś

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

The role of ATP-dependent activation of P2 purinergic receptors in the energetic disturbances in the brain of autistic-l...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Lidia Maria Babiec

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Testing the signaling function of creativity in context of intersexual and intrasexual selection.

Call: PRELUDIUM 20 , Panel: HS6

Principal investigator: Katarzyna Gałasińska - Grygorczuk

Szkoła Wyższa Psychologii Społecznej w Warszawie

Involvement of calcium signalling in activation of defence mechanisms in Hippeastrum x hyb bulbs after their wounding an...

Call: OPUS 2 , Panel: NZ9

Principal investigator: dr hab. Adriana Szmidt-Jaworska

Uniwersytet Mikołaja Kopernika, Wydział Biologii i Ochrony Środowiska

Involvement of the canonical Wnt signalling pathway in proper development of the thalamus

Call: OPUS 2 , Panel: NZ3

Principal investigator: dr hab. Marta Barbara Wiśniewska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Nanoplastic and silver nanoparticles as a factor modulating the activity of estrogen-dependent intracellular signaling p...

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Maria Grzelak

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Cell-to-cell heterogeneity of cross-wired cytokine signaling: filling the gaps between molecular origins and translation...

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Michał Komorowski

Instytut Podstawowych Problemów Techniki Polska Akademia Nauk

Omentin as a novel regulator of porcine uterus functioning during the periimplantation period

Call: SONATA 16 , Panel: NZ9

Principal investigator: dr Marta Kieżun

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Biologii i Biotechnologii