Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Adaptation of Proteins to Evade Premature Degradation by the Ubiquitin-Proteasome System

2021/42/E/NZ1/00190

Keywords:

ubiquitin-proteasome system posttranslational modifications ubiquitination pupylation protein-protein interactions protein metabolism molecular mechanisms of signalling processes

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_3: Proteomics
  • NZ3_1: Cell biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Wojciech Mieczysław Pokrzywa 

Number of co-investigators in the project: 6

Call: SONATA BIS 11 - announced on 2021-06-15

Amount awarded: 3 686 840 PLN

Project start date (Y-m-d): 2022-12-01

Project end date (Y-m-d): 2027-11-30

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis
    Authors:
    Natalia A. Szulc, Małgorzata Piechota, Lilla Biriczová, Pankaj Thapa, Wojciech Pokrzywa
    Academic press:
    iScience (rok: 2023, tom: 26, strony: 45681), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.isci.2023.108344 - link to the publication
  2. In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers
    Authors:
    Argho Aninda Paul, Natalia A. Szulc, Adrian Kobiela, Sara J. Brown, Wojciech Pokrzywa, Danuta Gutowska-Owsiak
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2023, tom: 10, strony: 45680), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmolb.2023.1105678 - link to the publication

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