Projects funded by the NCN

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69 projects found matching your search criteria :

  1. Abeta 4-x peptides as copper binding molecules resistant to chelating drugs, promoting the formation of amyloid oligomer...

    Call: OPUS 8 , Panel: ST5

    Principal investigator: prof. Wojciech Bal

    Instytut Biochemii i Biofizyki PAN

  2. Dynamic peptide-resorcinarene capsules synthesized by classical and mechanochemical methods

    Call: PRELUDIUM 8 , Panel: ST5

    Principal investigator: Hanna Jędrzejewska

    Instytut Chemii Organicznej PAN

  3. Engineering disulfide bridges in human beta-defensin 3 for novel antibacterial and antifungal activities

    Call: SONATA 8 , Panel: ST5

    Principal investigator: dr Aleksandra Walewska

    Uniwersytet Gdański, Wydział Chemii

  4. Synthesis and tandem mass spectrometry examination of new ionization tags based on thiazolidinecarboxylic acid and oxazo...

    Call: PRELUDIUM 8 , Panel: ST5

    Principal investigator: Bartosz Setner

    Uniwersytet Wrocławski, Wydział Chemii

  5. Determination of the exact structure of the complex (complexes) of AB1-16 peptide with Pd(II) ions using nuclear magneti...

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: Mariusz Mital

    Instytut Biochemii i Biofizyki PAN

  6. Can Fusobacterium nucleatum adhesion proteins increase prooxidative activity of iron and copper ions?

    Call: OPUS 7 , Panel: ST5

    Principal investigator: dr Kamila Stokowa-Sołtys

    Uniwersytet Wrocławski, Wydział Chemii

  7. Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: Agata Gitlin-Domagalska

    Uniwersytet Gdański, Wydział Chemii

  8. Application of macrocycles formed by substituted trithiocyanuric acid as template for self-assembly of peptide chains

    Call: PRELUDIUM 6 , Panel: ST5

    Principal investigator: dr Marta Cal

    Uniwersytet Wrocławski, Wydział Chemii

  9. Synthesis and structural study of modified porphyrinoids

    Call: PRELUDIUM 6 , Panel: ST5

    Principal investigator: Justyna Śniechowska

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  10. Synthesis, biological and biophysical evaluation of mRNA cap-peptide conjugates for targeted delivery of cap analogues t...

    Call: OPUS 6 , Panel: ST5

    Principal investigator: dr hab. Marzena Jankowska-Anyszka

    Uniwersytet Warszawski, Wydział Chemii

  11. Alpha factor of S. cerevisiae yeast: formation of copper and zinc complexes and their biological activity

    Call: OPUS 5 , Panel: ST5

    Principal investigator: prof. Wojciech Bal

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  12. Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

    Call: OPUS 1 , Panel: ST5

    Principal investigator: dr Marek Łuczkowski

    Uniwersytet Wrocławski, Wydział Chemii

  13. Synthesis and fragmentation of peptides conjugated with betaine derivatives - a search for isobaric markers for quantita...

    Call: OPUS 5 , Panel: ST4

    Principal investigator: prof. Zbigniew Szewczuk

    Uniwersytet Wrocławski, Wydział Chemii

  14. Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Artur Mucha

    Politechnika Wrocławska, Wydział Chemiczny

  15. Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Monika Łęgowska

    Uniwersytet Gdański, Wydział Chemii

  16. Fluorescent substrates of neutrophil proteinases: design, chemical synthesis , selection by the combinatorial chemistry ...

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Jadwiga Popow - Stellmaszyk

    Uniwersytet Gdański, Wydział Chemii

  17. Synthesis and biological studies of conjugates formed by peptide dendrimers and natural polyphenols and their analogs

    Call: OPUS 4 , Panel: ST5

    Principal investigator: prof. Zofia Lipkowska

    Instytut Chemii Organicznej PAN

  18. Quaternary ammonium salts of cryptando-peptidic conjugates. Synthesis and chemical properties.

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Remigiusz Bąchor

    Uniwersytet Wrocławski, Wydział Chemii

  19. Oxidative modification of amino acid residues in proteins - synthetic studies towards selective detection

    Call: SONATA 4 , Panel: ST5

    Principal investigator: dr Monika Kijewska

    Uniwersytet Wrocławski, Wydział Chemii

  20. Characterization of CD44/p53 signaling involved in the CD44-dependent cancer stem cells: small molecules and peptides, t...

    Call: MAESTRO 3 , Panel: ST5

    Principal investigator: prof. Tadeusz Holak

    Uniwersytet Jagielloński, Wydział Chemii

  21. Helical peptides rich in aminoisobutyric acid residues - synthesis, electrical properties and interactions with model li...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Joanna Juhaniewicz

    Uniwersytet Warszawski, Wydział Chemii

  22. The impact of synthetic modifications of the histidine side chain on coordination properties of analogues of the N-termi...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Izabela Zawisza

    Instytut Biochemii i Biofizyki PAN

  23. A novel strategy for construction of antifungal pro-drugs based on the cell-penetrating peptides

    Call: OPUS 3 , Panel: ST5

    Principal investigator: prof. Sławomir Milewski

    Politechnika Gdańska, Wydział Chemiczny

  24. Synthetic peptides - study on physochemical properties and biological activity

    Call: OPUS 3 , Panel: ST5

    Principal investigator: dr Wojciech Mrozik

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  25. Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Izabela Małuch

    Uniwersytet Gdański, Wydział Chemii

  26. Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Krzysztof Rolka

    Uniwersytet Gdański, Wydział Chemii

  27. Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

    Call: PRELUDIUM 2 , Panel: ST5

    Principal investigator: Jolanta Dyniewicz

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  28. Synthesis of deltorphin I and dermorphin analogues modified with alfa-alkyl-beta-azido(amino)alanine in postion 2 or 3.

    Call: PRELUDIUM 2 , Panel: ST5

    Principal investigator: Anika Lasota

    POLITECHNIKA ŁÓDZKA, Politechnika Łódzka, Wydział Chemiczny,

  29. Retro-inverso modification of zinc(II)–GLP-1 receptor agonist complexes – from bioinorganic chemistry to animal studies...

    Call: OPUS 26 , Panel: ST5

    Principal investigator: dr hab. Magdalena Rowińska-Żyrek

    Uniwersytet Wrocławski, Wydział Chemii

  30. Novel receptor materials for the construction of a bioelectronic nose for the rapid and efficient detection of lung canc...

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Wojciech Kamysz

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  31. Peptide-based luminescent coordination capsules and cages – towards bio-inspired cavities illuminated by chiral light

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Agnieszka Szumna

    Instytut Chemii Organicznej Polskiej Akademii Nauk

  32. The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Paulina Potok

    Uniwersytet Wrocławski, Wydział Chemii

  33. Conjugates of peptide nucleic acids with aminoglycosides and fluoroquinolones as a novel strategy to target multi-drug r...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Izabela Siekierska

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  34. De novo design of cavity-incorporating mini-proteins and their application in catalysis

    Call: OPUS 22 , Panel: ST4

    Principal investigator: prof. Łukasz Berlicki

    Politechnika Wrocławska

  35. Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr hab. Carlo Vascotto

    Instytut Hematologii i Transfuzjologii

  36. Design of metal-peptide complexes based on amyloid β sequence with a His-2 binding motif as selective receptors in elect...

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Aleksandra Tobolska

    Politechnika Warszawska

  37. Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Sylwia Rodziewicz-Motowidło

    Uniwersytet Gdański, Wydział Chemii

  38. Blocking HVEM/LIGHT interactions using peptides - an innovative approach to immunosuppression

    Call: PRELUDIUM BIS 2 , Panel: ST4

    Principal investigator: dr hab. Adam Sieradzan

    Uniwersytet Gdański, Wydział Chemii

  39. Development of tools for the rational design of peptide therapeutics

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr hab. Sebastian Kmiecik

    Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

  40. Novel analogs of human cathelicidin (LL-37) with enhanced resistant to enzymatic degradation. Design chemical synthesis ...

    Call: PRELUDIUM BIS 1 , Panel: ST4

    Principal investigator: prof. Adam Lesner

    Uniwersytet Gdański, Wydział Chemii

  41. Evaluation of characteristic interactions of synthetic peptides derived from HarmOBP7 aldehyde binding site.

    Call: PRELUDIUM 17 , Panel: ST5

    Principal investigator: Tomasz Wasilewski

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  42. Innovative hybrid materials useful in the syntheis of dressings for the treatment of diabetic foot ulcers

    Call: OPUS 16 , Panel: ST8

    Principal investigator: dr hab. Beata Kolesińska

    Politechnika Łódzka, Wydział Chemiczny

  43. Fundamentals of copper exchange kinetics between model peptides and small molecules.

    Call: PRELUDIUM 16 , Panel: ST5

    Principal investigator: Radosław Kotuniak

    Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

  44. De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

    Call: OPUS 16 , Panel: ST5

    Principal investigator: dr hab. Łukasz Berlicki

    Politechnika Wrocławska

  45. Searching for mu opioid receptor peptide agonists with G protein/beta-arrestin biased profile and their pharmacological ...

    Call: SONATA 14 , Panel: ST5

    Principal investigator: dr Justyna Piekielna-Ciesielska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  46. Lipid nanoparticles loaded with antibacterial peptides as an alternative treatment for bacterial infections

    Call: PRELUDIUM 15 , Panel: ST5

    Principal investigator: dr Katarzyna Reczyńska-Kolman

    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

  47. Synthesis of new functional cages based on trigonal peptidic building blocks by dynamic covalnt chemistry

    Call: PRELUDIUM 15 , Panel: ST5

    Principal investigator: Marcin Grajda

    Instytut Chemii Organicznej Polskiej Akademii Nauk

  48. New class of nucelus penetrating peptides. Design, synthesis and mechanism of action

    Call: OPUS 14 , Panel: ST5

    Principal investigator: dr hab. Magdalena Wysocka

    Uniwersytet Gdański, Wydział Chemii

  49. Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

    Call: SONATA 13 , Panel: ST5

    Principal investigator: dr Marta Spodzieja

    Uniwersytet Gdański, Wydział Chemii

  50. Understanding the interactions of zinc with metal-sensing transcriptional regulators from Mycobacterial ArsR-family

    Call: SONATA 13 , Panel: ST5

    Principal investigator: dr Sławomir Potocki

    Uniwersytet Wrocławski, Wydział Chemii

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