Projects funded by the NCN

RNA hybrid duplex-quadruplex structures with dual functionality as a new tool for silecing of gene expression

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Zofia Gdaniec

Instytut Chemii Bioorganicznej PAN

P-Stereodefined phosphorothioate analogs of DNA containing within nucleobases modifications preventing Watson-Crick base...

Call: OPUS 6 , Panel: ST5

Principal investigator: dr Anna Maciaszek

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification.

Call: SONATA BIS 3 , Panel: NZ1

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Structure defined oligonucleotides for revealing fundamental insights into structure and function of RNAs

Call: MAESTRO 4 , Panel: ST5

Principal investigator: prof. Ryszard Kierzek

Instytut Chemii Bioorganicznej PAN

Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Marcin Chmielewski

Instytut Chemii Bioorganicznej PAN

Multitasking polymeric lattices included selected DNA oligonucleotide sequences - synthesis, modifications and physioche...

Call: SONATA 3 , Panel: ST5

Principal investigator: dr Ewelina Zabost

Uniwersytet Warszawski, Wydział Chemii

Stereodefined phosphorothioate analogs of DNA with incorporated LNA-type nucleosides - synthesis and properties of compl...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Guga

Centrum Badań Molekularnych i Makromolekularnych PAN

New approaches towards modulating selective and functional activities of antisense oligonucleotides

Call: OPUS 2 , Panel: ST5

Principal investigator: prof. Ryszard Kierzek

Instytut Chemii Bioorganicznej PAN

New methods for the determination of RNA secondary structure, tools towards studies biological activities of RNAs

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Ryszard Kierzek

INSTYTUT CHEMII BIOORGANICZNEJ PAN

Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza, Wydział Chemii

Evaluation of the therapeutic potential of synthetic miRNA-223-3p analog in a rat model of severe asthma

Call: SONATA 19 , Panel: NZ4

Principal investigator: dr Wojciech Langwiński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Injectable and RNA-releasing nanofibrous microcarriers for intervertebral disc regeneration

Call: SONATA BIS 13 , Panel: ST5

Principal investigator: dr Paweł Nakielski

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

Elongation factors in synthesis of developmentally controlled non-coding RNA

Call: OPUS 23 , Panel: NZ2

Principal investigator: dr Jacek Nowak

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

Transport of RNA Across Mitochondrial Membranes: towards mitochondrial genome editing

Call: POLONEZ BIS 2 , Panel: NZ1

Principal investigator: dr Nicola De Franceschi

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Crystallographic analysis of RNA-ligand complexes. Towards rational design oflead compounds for development of therapies...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Kiliszek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Synthesis and structural/biophysical studies of model mRNA/mt-tRNA oligomers to evaluate the role of modified nucleoside...

Call: OPUS 22 , Panel: ST4

Principal investigator: dr hab. Grażyna Leszczyńska

Politechnika Łódzka

Multifunctional smart nanostructured platforms for light-triggered wound healing polytherapy

Call: SONATA BIS 10 , Panel: ST5

Principal investigator: dr hab. Filippo Pierini

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

Cellular adaptation to cold.

Call: GRIEG 1 , Panel: NZ3

Principal investigator: dr Wojciech Pokrzywa

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

Synthesis and characterization of new molecular probes for monitoring activity of enzymes associated with RNA decapping ...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Role of RNA binding proteins in resistance to therapy of leukemia cells in bone marrow niche

Call: HARMONIA 10 , Panel: NZ3

Principal investigator: dr Paulina Podszywałow-Bartnicka

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Why Nature introduced selenium to wobble nucleosides in transfer RNA?

Call: OPUS 15 , Panel: ST5

Principal investigator: prof. Barbara Nawrot

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Development of methodology aiming at stabilisation of RNA in a hairpin form for crystallographic studies

Call: SONATA BIS 7 , Panel: NZ1

Principal investigator: dr hab. Agnieszka Kiliszek

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered...

Call: OPUS 13 , Panel: ST5

Principal investigator: prof. Elżbieta Sochacka

Politechnika Łódzka, Wydział Chemiczny

How RNA structure governs messenger RNA function? Exploring structural and functional aspects essential for synthesis of...

Call: SONATA 12 , Panel: NZ1

Principal investigator: dr Leszek Błaszczyk

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Identification of nucleolar protein partners of phosphoglycerate mutase muscle isoenzyme - PGAM2

Call: PRELUDIUM 11 , Panel: NZ1

Principal investigator: Janusz Wiśniewski

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Chemically modified mRNA for studies on cellular processes and therapeutic applications

Call: OPUS 11 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Double stranded probes, in which both oligonucleotide components hybridize according to the Hoogsteen's interactions, an...

Call: OPUS 10 , Panel: ST5

Principal investigator: dr hab. Piotr Guga

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Tecto-RNA nano-structures for gene expression regulation in a model system

Call: OPUS 10 , Panel: ST5

Principal investigator: dr hab. Arkadiusz Chworoś

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

catalytic nucleic acids in of the new generation in the regulation of genetic information

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Jan Barciszewski

Instytut Chemii Bioorganicznej PAN

Study of the mechanisms involved in synthesis of non-coding transcripts

Call: OPUS 9 , Panel: NZ2

Principal investigator: dr Jacek Nowak

Instytut Biochemii i Biofizyki PAN

Dissecting mechanisms of RNA-based Stress Granules formation, their structure and role in the development of Multi-Drug ...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Witold Szaflarski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Studies on influence of cytochrome c on oxidative damage of 2-thiouridines built in an RNA chain

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Anna Chwiałkowska

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk