Projects funded by the NCN


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15 projects found matching your search criteria :

  1. Molecular mechanisms linking BRAF mutations and the expression of immunoregulatory molecules, galectin-1 and PD-L1 in me...

    Call: PRELUDIUM 8 , Panel: NZ5

    Principal investigator: Maja Wasylecka-Juszczyńska

    Instytut Hematologii i Transfuzjologii

  2. The role of the immune checkpoints in the pathomechanism of depressive disorders.

    Call: OPUS 22 , Panel: NZ6

    Principal investigator: prof. Marta Kubera

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  3. Photoswitchable and chimeric molecules for spatially restricted and endoplasmic reticulum-specific blockade of PD-L1 pro...

    Call: SONATA BIS 11 , Panel: NZ7

    Principal investigator: dr Łukasz Skalniak

    Uniwersytet Jagielloński, Wydział Chemii

  4. The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Magdalena Żarnik

    Uniwersytet Jagielloński, Wydział Chemii

  5. The clinical significance of immunosuppression in ovarian cancer microenvironments

    Call: PRELUDIUM 20 , Panel: NZ6

    Principal investigator: Anna Pawłowska

    Uniwersytet Medyczny w Lublinie

  6. Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

    Call: SONATA 16 , Panel: ST4

    Principal investigator: dr Ewa Surmiak

    Uniwersytet Jagielloński, Wydział Chemii

  7. Photodynamic therapy combined with PD-1/PD-L1 blockade immunotherapy: new possibilities for the treatment of immunogenic...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: dr hab. Janusz Dąbrowski

    Uniwersytet Jagielloński, Wydział Chemii

  8. Structure optimization of the PD-1/PD-L1 inhibitors based on the terphenyl scaffold

    Call: PRELUDIUM 19 , Panel: ST4

    Principal investigator: dr Damian Muszak

    Uniwersytet Jagielloński, Wydział Chemii

  9. Evaluation of the activity of MDM2-p53 antagonist RG7388 in mouse cancer models, alone and in combination with anti-PD-1...

    Call: PRELUDIUM 18 , Panel: NZ5

    Principal investigator: Aneta Wiśniewska

    Uniwersytet Jagielloński, Wydział Chemii

  10. Development of a three-dimensional in vitro model for studying the mechanisms of immunostimulatory activity of PD-1/PD-L...

    Call: PRELUDIUM 18 , Panel: NZ5

    Principal investigator: Justyna Kocik

    Uniwersytet Jagielloński, Wydział Chemii

  11. Development of macrocyclic peptide antagonists of the PD-1/PD-L1 pathway. Charcterization of simultaneous administration...

    Call: SONATA 14 , Panel: NZ7

    Principal investigator: dr Katarzyna Magiera-Mularz

    Uniwersytet Jagielloński, Wydział Chemii

  12. De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

    Call: OPUS 16 , Panel: ST5

    Principal investigator: dr hab. Łukasz Berlicki

    Politechnika Wrocławska

  13. Small-molecule inhibitors for characterization of the interaction between extracellular domains of Programmed Cell Death...

    Call: MAESTRO 9 , Panel: ST5

    Principal investigator: prof. Tadeusz Holak

    Uniwersytet Jagielloński, Wydział Chemii

  14. Strukturalne aspekty oddziaływania ludzkich białek PD-1/PD-L1 oraz niskocząsteczkowe inhibitory tego oddziaływania.

    Call: ETIUDA 4 , Panel: NZ1

    Principal investigator: Krzysztof Żak

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  15. Synthesis and Struktural Characterization of Small-Molecule Probes for the Programmed Death 1/ Programmed Death Ligand 1...

    Call: PRELUDIUM 10 , Panel: ST5

    Principal investigator: Katarzyna Guzik

    Uniwersytet Jagielloński, Wydział Chemii