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Strukturalne aspekty oddziaływania ludzkich białek PD-1/PD-L1 oraz niskocząsteczkowe inhibitory tego oddziaływania.

2016/20/T/NZ1/00519

Keywords:

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Krzysztof Żak 

Number of co-investigators in the project: 2

Call: ETIUDA 4 - announced on 2015-12-15

Amount awarded: 91 352 PLN

Project start date (Y-m-d): 2016-10-01

Project end date (Y-m-d): 2017-09-30

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Bioactive macrocyclic inhibitors of the PD-1/PD-L1 immune checkpoint.
    Authors:
    Magiera-Mularz K, Skalniak S, Zak KM, Musielak B, Rudzinska-Szostak E, Berlicki L, Kocik J, Grudnik P, Sala D, Zizigas-Zarganis T, Shaabani S, Domling A, Dubin G, Tolak TA
    Academic press:
    Angewandte Chemie International Edition (rok: 2017, tom: 56, strony: 13732–13735), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1002/anie.201707707 - link to the publication
  2. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1
    Authors:
    Guzik K, Zak KM, Grudnik P, Magiera K, Musielak B, Törner R, Skalniak L, Domling A, Dubin G, Holak TA
    Academic press:
    Journal of Medicinal Chemistry (rok: 2017, tom: 60, strony: 5857–5867), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.7b00293 - link to the publication
  3. Structural biology of the immune checkpoint receptor PD-1 and its ligands PD-L1/PD-L2.
    Authors:
    Zak KM, Grudnik P, Magiera K, Dömling A, Dubin G, Holak TA
    Academic press:
    Structure (rok: 2017, tom: 25, strony: 1163-1174), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.str.2017.06.011 - link to the publication
  4. A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
    Authors:
    Surmiak E, Twarda-Clapa A, Zak KM, Musielak B, Tomala M, Kubica K, Grudnik P, Madej M, Jabłoński M, Potempa J, Kalinowska-Tłuścik J, Dubin G, Dömling A, Holak TA
    Academic press:
    ACS Chemical Biology (rok: 2016, tom: 11, strony: 3310–3318), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acschembio.6b00596 - link to the publication
  5. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
    Authors:
    Skalniak L, Zak KM, Guzik K, Magiera K, Musielak B, Pachota M, Szelazek B, Kocik J, Grudnik P, Tomala M, Krzanik S, Pyrc K, Domling A, Dubin G, Holak TA
    Academic press:
    Oncotarget (rok: 2017, tom: 8, strony: 72167-72181), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.20050 - link to the publication

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