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The effect of omega-3 fatty acid-enriched diet on the myelination impairment and the depression-like phenotype induced by maternal high-fat diet during pregnancy and lactation in offspring.

2020/39/D/NZ5/02581

Keywords:

depression myelination high-fat diet omega-3 fatty acids

Descriptors:

  • NZ5_003:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Irena Maria Smaga-Maślanka 

Number of co-investigators in the project: 5

Call: SONATA 16 - announced on 2020-09-15

Amount awarded: 999 800 PLN

Project start date (Y-m-d): 2021-07-20

Project end date (Y-m-d): 2025-07-19

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (3)
  1. A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex
    Authors:
    Frankowska M, Surówka P, Gawlińska K, Borczyk M, Korostyński M, Filip M, Smaga I.
    Academic press:
    Frontiers in Molecular Neuroscience (rok: 2024, tom: 16, strony: 1303718), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2023.1303718 - link to the publication
  2. Understanding the Links among Maternal Diet, Myelination, and Depression: Preclinical and Clinical Overview.
    Authors:
    Smaga Irena
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 540), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11030540 - link to the publication
  3. Dietary Intervention with Omega-3 Fatty Acids Mitigates Maternal High-Fat Diet-Induced Behavioral and Myelin-Related Alterations in Adult Offspring.
    Authors:
    Jastrzebska J, Frankowska M, Wesołowska J, Filip M, Smaga I
    Academic press:
    Current Neuropharmacology (rok: 2025, tom: 23(3), strony: 329-348), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X23666241014164940 - link to the publication
  1. A maternal high-fat diet during pregnancy and lactation altered myelination and induced depressive-like phenotype in rat offspring.
    Authors:
    Smaga I, Surówka P, Gawlińska K, Pieniążek R, Frankowska M, Filip M
    Conference:
    Glia, Wiley Online Library, Volume 71, Issue S1, Supplement (rok: 2023, tom: XVI European Meeting on Glial Cells in Health and Disease, strony: E182-E1187), Wydawca: Wiley Online Library
    Data:
    konferencja 8-11.07.2023
    Status:
    Published
    DOI:
    10.1002/glia.24419 - link to the publication
  2. Changes in myelination induced by a maternal high-fat diet during pregnancy and lactation as a potential mechanism of depression in rat offspring
    Authors:
    Smaga I, Surówka P, Gawlińska K, Pieniążek R, Frankowska M, Filip M
    Conference:
    Abstract book (rok: 2023, tom: 5th Central European Biomedical Congress, Future trends in health interventions, strony: 88), Wydawca: komitet organizacyjny
    Data:
    konferencja 29.05-1.06.2023
    Status:
    Published
    DOI:
    link to the publication
  3. Omega-3 fatty acid-enriched diet reverses maternal high-fat diet-induced depression-like behavior and myelin-related changes in rat offspring.
    Authors:
    Śliwa M, Jastrzębska J, Frankowska M, Pieniążek R, Wesołowska J, Filip M, Smaga I
    Conference:
    Abstract book (rok: 2024, tom: "Neuropharmacology towards neuroplasticity: A journey from historical roots to future innovations." Scientific symposium held on the 70th Anniversary of the Maj Institute of Pharmacology PAS, strony: 27), Wydawca: komitet organizacyjny
    Data:
    konferencja 2-3.12.2024
    Status:
    Published
    DOI:
    link to the publication

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