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The effect of omega-3 fatty acid-enriched diet on the myelination impairment and the depression-like phenotype induced by maternal high-fat diet during pregnancy and lactation in offspring.

2020/39/D/NZ5/02581

Keywords

Descriptors

  • NZ5_003: Patogeneza chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Irena Maria Smaga-Maślanka

Number of co-investigators in the project: 5

Call

SONATA 16 – announced on 2020-09-15

Amount awarded
999 800 PLN
Project start date
2021-07-20
Project end date
2025-07-19
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

  1. Dietary Intervention with Omega-3 Fatty Acids Mitigates Maternal High-Fat Diet-Induced Behavioral and Myelin-Related Alterations in Adult Offspring.

    Authors:
    Jastrzebska J, Frankowska M, Wesołowska J, Filip M, Smaga I
    Academic press:
    Current Neuropharmacology (year: 2025, volume: 23(3), pages: 329-348), Publisher: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X23666241014164940 – link to the publication

  2. A maternal high-fat diet during pregnancy and lactation induced depression-like behavior in offspring and myelin-related changes in the rat prefrontal cortex

    Authors:
    Frankowska M, Surówka P, Gawlińska K, Borczyk M, Korostyński M, Filip M, Smaga I.
    Academic press:
    Frontiers in Molecular Neuroscience (year: 2024, volume: 16, pages: 1303718), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnmol.2023.1303718 – link to the publication

  3. Understanding the Links among Maternal Diet, Myelination, and Depression: Preclinical and Clinical Overview.

    Authors:
    Smaga Irena
    Academic press:
    Cells (year: 2022, volume: 11, pages: 540), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11030540 – link to the publication

Articles in post-conference publications (5)

  1. A maternal high-fat diet during pregnancy and lactation altered myelination and induced depressive-like phenotype in rat offspring.

    Authors:
    Smaga I, Surówka P, Gawlińska K, Pieniążek R, Frankowska M, Filip M
    Conference:
    Glia, Wiley Online Library, Volume 71, Issue S1, Supplement (year: 2023, volume: XVI European Meeting on Glial Cells in Health and Disease, pages: E182-E1187), Publisher: Wiley Online Library
    Date:
    conference 8-11.07.2023
    Status:
    Published
    DOI:
    10.1002/glia.24419 – link to the publication

  2. Changes in myelination induced by a maternal high-fat diet during pregnancy and lactation as a potential mechanism of depression in rat offspring

    Authors:
    Smaga I, Surówka P, Gawlińska K, Pieniążek R, Frankowska M, Filip M
    Conference:
    Abstract book (year: 2023, volume: 5th Central European Biomedical Congress, Future trends in health interventions, pages: 88), Publisher: komitet organizacyjny
    Date:
    conference 29.05-1.06.2023
    Status:
    Published
    DOI:
    link to the publication

  3. Wpływ kwasów tłuszczowych omega-3 na potomstwo matek karmionych dietą wysokotłuszczową: skutki poznawcze i molekularne.

    Authors:
    Joanna Jastrzębska, Małgorzata Frankowska, Renata Pieniążek, Małgorzata Filip, Irena Smaga
    Conference:
    Książka streszczeń. (year: 2025, volume: Drugie Dni Farmakologii Polskiej 2025, pages: 42), Publisher: Polskie Towarzystwo Farmakologiczne
    Date:
    conference 8-11.06.2025
    Status:
    Published
    DOI:
    link to the publication

  4. Omega-3 fatty acid-enriched diet reverses maternal high-fat diet-induced depression-like behavior and myelin-related changes in rat offspring.

    Authors:
    Śliwa M, Jastrzębska J, Frankowska M, Pieniążek R, Wesołowska J, Filip M, Smaga I
    Conference:
    Abstract book (year: 2024, volume: Neuropharmacology towards neuroplasticity: A journey from historical roots to future innovations. Scientific symposium held on the 70th Anniversary of the Maj Institute of Pharmacology PAS, pages: 27), Publisher: komitet organizacyjny
    Date:
    conference 2-3.12.2024
    Status:
    Published
    DOI:
    link to the publication

  5. Wpływ kwasów tłuszczowych DHA i EPA na fenotyp depresyjny oraz procesy mielinizacji mózgu u potomstwa.

    Authors:
    Maya Śliwa, Joanna Jastrzębska, Małgorzata Frankowska, Renata Pieniążek, Julita Wesołowska, Małgorzata Filip, Irena Smaga
    Conference:
    Książka streszczeń. (year: 2025, volume: Drugie Dni Farmakologii Polskiej 2025, pages: 54), Publisher: Polskie Towarzystwo Farmakologiczne
    Date:
    conference 8-11.06.2025
    Status:
    Published
    DOI:
    link to the publication

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