Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identification and therapeutic use of proteasome machinery targets in human cancer

2017/25/B/NZ5/01343

Keywords:

cancer proteasome carfilzomib proteomics transcriptomics systems biology organoids

Descriptors:

  • NZ2_3: Proteomics
  • NZ2_9: Systems biology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dawid Walerych 

Number of co-investigators in the project: 5

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 293 600 PLN

Project start date (Y-m-d): 2018-02-13

Project end date (Y-m-d): 2022-02-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do odsysania z pompą membranową.
  2. Mała, chłodzona mikro-wirówka (10 000 PLN)
  3. Mikroskop odwrócony.
  4. Wyposażenie komputerowe (serwer wieloprocesorowy z mozliowścią przechowywania i backupu danych multi-omicznych) (10 000 PLN)
  5. wytrząsarka/kołyska laboratoryjna.
  6. Łaźnia wodna.
  7. Termomikser (5 000 PLN)
  8. Wytrząsarka z inkubacją.
  9. lodówko-zamrażarka.
  10. zautomatyzowany homogenizator do tkanek (25 000 PLN)
  11. Aparatura do elektorforezy SDS-PAGE i tarnsferu do metody western-blot (włącznie z transformatorem) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. A Driver NeverWorks Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer
    Authors:
    Maria Grześ, Magdalena Oroń, Zuzanna Staszczak, Akanksha Jaiswar, Magdalena Nowak-Niezgoda, Dawid Walerych *
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 1532-1564), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12061532 - link to the publication
  2. The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells.
    Authors:
    Magdalena Oroń, Marcin Grochowski, Akanksha Jaiswar, Justyna Legierska, Kamil Jastrzębski, Magdalena Nowak-Niezgoda, Małgorzata Kołos, Wojciech Kaźmierczak, Tomasz Olesiński, Małgorzata Lenarcik, Magdalena Cybulska, Michał Mikula, Alicja Żylicz, Marta Miączyńska, Katharina Zettl, Jacek R. Wiśniewski, Dawid Walerych
    Academic press:
    Cell Reports (rok: 2022, tom: 40, strony: 111428), Wydawca: Cell Press/Elsevier
    Status:
    Published
    DOI:
    10.1016/j.celrep.2022.111428 - link to the publication
  3. The response network of HSP70 defines vulnerabilities in cancer cells with the inhibited proteasome
    Authors:
    Magdalena Oroń, Marcin Grochowski, Akanksha Jaiswar, Justyna Legierska, Kamil Jastrzębski, Magdalena Nowak-Niezgoda, Małgorzata Kołos, Wojciech Kaźmierczak, Tomasz Olesiński, Małgorzata Lenarcik, Magdalena Cybulska, Michał Mikuła, Alicja Żylicz, Marta Miączyńska, Katherina Zettl, Jacek R. Wiśniewski, Dawid Walerych
    Academic press:
    bioRxv (rok: 2022, ), Wydawca: Preprint w serwisie bioRxiv.org
    Status:
    Published
    DOI:
    10.1101/2021.11.16.468807 - link to the publication