Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Towards experimental pharmacology of endothelium in vivo based on multiparameter method of the assessment of vascular endothelial function in mice with the use of MR imaging techniques

2016/23/N/NZ5/00595

Keywords:

Magnetic Resonance Imaging Endothelium Atherosclerosis Vitamin K

Descriptors:

  • NZ5_5: Diagnostics in human diseases
  • NZ4_4: Pathophysiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anna Bar 

Number of co-investigators in the project: 2

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 99 900 PLN

Project start date (Y-m-d): 2017-07-17

Project end date (Y-m-d): 2019-07-16

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop (5 100 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Vitamin K2-MK-7 improves nitric oxide-dependent endothelial function in ApoE/LDLR-/- mice.
    Authors:
    Bar A, Kuś K, Manterys A, Proniewski B, Sternak M, Przyborowski K, Moorlag M, Sitek B, Marczyk B, Jasztal A, Skórka T, Franczyk-Żarów M, Kostogrys R, Chlopicki S.
    Academic press:
    Vascular Pharmacology (rok: 2019, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.14814/phy2.14161 - link to the publication
  2. Degradation of Glycocalyx and Multiple Manifestations of Endothelial Dysfunction Coincide in the Early Phase of Endothelial Dysfunction Before Atherosclerotic Plaque Development in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice
    Authors:
    Bar A, Targosz-Korecka M, Suraj J, Proniewski B, Jasztal A, Marczyk B, Sternak M, Przybyło M, Kurpińska A, Walczak M, Kostogrys RB, Szymonski M, Chlopicki S.
    Academic press:
    Journal of the American Heart Association (rok: 2019, tom: 8(6), strony: PMC6475045), Wydawca: John Wiley & Sons on behalf of the American Heart Association (United States)
    Status:
    Published
    DOI:
    10.1161/JAHA.118.011171 - link to the publication
  3. The Deletion of Endothelial Sodium Channel α (αENaC) Impairs Endothelium-Dependent Vasodilation and Endothelial Barrier Integrity in Endotoxemia in Vivo
    Authors:
    Sternak M, Bar A, Adamski MG, Mohaissen T, Marczyk B, Kieronska A, Stojak M, Kus K, Tarjus A, Jaisser F, Chlopicki S
    Academic press:
    Frontiers in Pharmacology (rok: 2018, tom: 9, strony: 178), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fphar.2018.00178 - link to the publication

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