Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Histone demethylase JMJD3 as an epigenetic regulator in the senescence-associated secretory phenotype and cancer

2016/21/D/NZ3/00641

Keywords:

epigenetics chromatin cancer senescence

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ3_4: Ageing

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Patrick Perrigue 

Number of co-investigators in the project: 5

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 632 400 PLN

Project start date (Y-m-d): 2017-02-17

Project end date (Y-m-d): 2020-11-16

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator do hodowli Wypławków (15 000 PLN)
  2. Komputer z oprogramowaniem (MS Office, pakiet Corell, pakiet Adobe, Endnote, GraphPad Prism) oraz wyposażeniem (mysz, klawiatura). (12 000 PLN)
  3. wirówka (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. Cancer stem cell-inducing media activates senescence reprogramming in fibroblasts
    Authors:
    Patrick M Perrigue, Magdalena Rakoczy, Kamila P Pawlicka, Agnieszka Belter, Małgorzata Giel-Pietraszuk, Mirosława Naskręt-Barciszewska, Jan Barciszewski, Marek Figlerowicz
    Academic press:
    Cancers (rok: 2020, tom: 12(7), strony: 1745), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/cancers12071745 - link to the publication
  2. Total DNA Methylation Changes Reflect Random Oxidative DNA Damage in Gliomas
    Authors:
    Anna-Maria Barciszewska, Małgorzata Giel-Pietraszuk, Patrick M. Perrigue, Mirosława Naskręt-Barciszewska
    Academic press:
    Cells (rok: 2019, tom: 8(9), strony: 1065), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8091065 - link to the publication
  1. Depletion of histone H3K27me3 is an epigenetic stress that induces cellular senescence in fibroblasts
    Authors:
    Patrick M. Perrigue, Kamila Pawlicka, Justyna Obacz, Marek Figlerowicz, Jan Barciszewski
    Conference:
    Congress BIO2018 (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21.09.2018
    Status:
    Published

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