Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New ways of early diagnosticts of colorectar cancer using Sirt3 as mitochondrial DNA repair regulator

2015/19/B/NZ5/01421

Keywords:

colorectal cancer sirtuins mitochondrium BER

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ2_1: Molecular genetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Międzywydziałowa Katedra Chemii i Biochemii Medycznej

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ireneusz Majsterek 

Number of co-investigators in the project: 5

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 788 188 PLN

Project start date (Y-m-d): 2016-06-28

Project end date (Y-m-d): 2019-06-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do transferu Trans-Blot® Turbo™ Transfer System (10 000 PLN)
  2. Lodówka niskotemperaturowa -80*C Panasonic.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases
    Authors:
    Tomasz Poplawski, Dariusz Pytel, Jaroslaw Dziadek, Ireneusz Majsterek
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2019, tom: Volume 2019, strony: 45293), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/6949347 - link to the publication
  2. Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer.
    Authors:
    Jacek Kabzinski., Anna Walczak, Ireneusz Majsterek
    Academic press:
    Genetics Research (rok: 2022, tom: 2022, strony: 45301), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2022/7299555; - link to the publication
  3. Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer
    Authors:
    Kabziński Jacek, Walczak Anna, Mik Michał, Majsterek Ireneusz
    Academic press:
    Polish Journal of Surgery (rok: 2020, tom: 92 (1), strony: 45295), Wydawca: Index Copernicus Ltd.
    Status:
    Published
    DOI:
    10.5604/01.3001.0013.5539 - link to the publication
  4. Association between SOD1, CAT, GSHPX1 polymorphisms and the risk of inflammatory bowel disease in the Polish population
    Authors:
    Malgorzata Mrowicka, Jerzy Mrowicki, Michal Mik, Radoslaw Wojtczak, Lukasz Dziki, Adam Dziki, Ireneusz Majsterek
    Academic press:
    Oncotarget (rok: 2018, tom: 2018, strony: 45299), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.22675 - link to the publication
  5. Association of Base Excision Repair pathway genes OGG1, XRCC1 and MUTYH polymorphisms and the level of 8-oxo-guanine with increased risk of colorectal cancer occurrence
    Authors:
    Jacek Kabzinski, Ireneusz Majsterek
    Academic press:
    International Journal of Occupational Medicine and Environmental Health (rok: 2022, tom: 2022, strony: 45310), Wydawca: Nofer Institute of Occupational Medicine
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  1. DNA damage and Sirt3 dependent mitochondrial oxidative stress
    Authors:
    Ireneusz Majsterek, Lukasz Dziki, Adam Dziki
    Conference:
    3rd DNA Replication/Repair Structures and Cancer Conference, Cancun, Mexico. (rok: 2018, ), Wydawca: Fusion Conferences
    Data:
    konferencja 11th – 15th February
    Status:
    Published
  2. Sirt3 regulates DNA repair proteins APE1 and NEIL1 response to oxidative stress and UPR in colorectal cancer
    Authors:
    Ireneusz Majsterek, Michał Mik, Lukasz Dziki, Adam Dziki, Jacek Kabzinski
    Conference:
    4th DNA Repair/Replication Structures and Cancer Conference, Nassau, Bahamas. (rok: 2020, ), Wydawca: Fusion Conferences Limited
    Data:
    konferencja 16-20th February
    Status:
    Accepted for publication
  3. Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer
    Authors:
    Jacek Kabzinski, Michał Mik, Lukasz Dziki, Adam Dziki, Ireneusz Majsterek
    Conference:
    4th DNA Repair/Replication Structures and Cancer Conference, Nassau, Bahamas. (rok: 2020, ), Wydawca: Fusion Conferences Limited
    Data:
    konferencja 16-20th February
    Status:
    Accepted for publication
  4. Role of Sirt3 and DNA repair efficiency in colorectal cancer development
    Authors:
    Jacek Kabzinski, Lukasz Dziki, Adam Dziki, Ireneusz Majsterek
    Conference:
    3rd DNA Replication/Repair Structures and Cancer Conference, Cancun, Mexico. (rok: 2018, ), Wydawca: Fusion Conferences
    Data:
    konferencja 11th – 15th February
    Status:
    Published

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