Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Comprehensive analysis of the therapeutic potential of oligonucleotides for the treatment of polyglutamine diseases

2015/17/D/NZ5/03443

Keywords:

polyglutamine diseases Huntington's disease RNA interference

Descriptors:

  • NZ1_1: Molecular biology
  • NZ5_7: Human disease treatment
  • NZ3_5: Molecular neurobiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Fiszer 

Number of co-investigators in the project: 7

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 658 000 PLN

Project start date (Y-m-d): 2016-02-25

Project end date (Y-m-d): 2021-02-24

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometr do określania stężenia RNA i białka (46 000 PLN)
  2. Obiektyw 100x klasy plan fluorytowej do jasnego pola oraz kontrastu fazowego z wkładką do kontrastu (13 000 PLN)
  3. Komputer stancjonarny.
  4. Aparat to elektroforezy i transferu białek (11 000 PLN)
  5. Komputer przenośny.

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (2)
  1. A potential role of extended simple sequence repeats in competing endogenous RNA crosstalk
    Authors:
    Tomasz M. Witkoś, Włodzimierz J. Krzyżosiak, Agnieszka Fiszer, Edyta Kościańska
    Academic press:
    RNA Biology (rok: 2018, tom: 15, strony: 1399-1409), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/15476286.2018.1536593 - link to the publication
  2. Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells
    Authors:
    Agnieszka Fiszer, Joanna P. Wroblewska, Bartosz M. Nowak, Wlodzimierz J. Krzyzosiak
    Academic press:
    Genes (rok: 2016, tom: 7, strony: E132), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes7120132 - link to the publication
  3. Silencing of genes responsible for polyQ diseases using chemically modified single-stranded siRNAs
    Authors:
    Agnieszka Fiszer, Marianna E. Ellison-Klimontowicz, Wlodzimierz J. Krzyzosiak
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 759-764), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2016_1336 - link to the publication
  4. Reduction of Huntington's Disease RNA Foci by CAG Repeat-Targeting Reagents
    Authors:
    Martyna O. Urbanek, Agnieszka Fiszer, Wlodzimierz J. Krzyzosiak
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2017, tom: 11, strony: 82), Wydawca: FRONTIERS MEDIA SA
    Status:
    Published
    DOI:
    10.3389/fncel.2017.00082 - link to the publication
  5. Generation of New Isogenic Models of Huntington's Disease Using CRISPR-Cas9 Technology
    Authors:
    Dabrowska M, Ciolak A, Kozlowska E, Fiszer A, Olejniczak M
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 1854), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21051854 - link to the publication
  6. Generation of human iPS cell line IBCHi001-A from dentatorubral-pallidoluysian atrophy patient's fibroblasts
    Authors:
    Emilia Kozlowska, Agata Ciolak, Marta Olejniczak, Agnieszka Fiszer
    Academic press:
    Stem Cell Research (rok: 2019, tom: 39, strony: 101512), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2019.101512 - link to the publication
  7. What, When and How to Measure-Peripheral Biomarkers in Therapy of Huntington's Disease
    Authors:
    Przybyl L, Wozna-Wysocka M, Kozlowska E, Fiszer A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1561), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041561 - link to the publication
  8. Artificial miRNAs targeting CAG repeat expansion in ORFs cause rapid deadenylation and translation inhibition of mutant transcripts
    Authors:
    Ciesiolka A, Stroynowska-Czerwinska A, Joachimiak P, Ciolak A, Kozlowska E, Michalak M, Dabrowska M, Olejniczak M, Raczynska KD, Zielinska D, Wozna-Wysocka M, Krzyzosiak WJ, Fiszer A.
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2020, tom: 78, strony: 1577-1596), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00018-020-03596-7 - link to the publication
  9. Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts
    Authors:
    Ciolak A, Krzyzosiak WJ, Kozlowska E, Fiszer A.
    Academic press:
    STEM CELL RESEARCH (rok: 2020, tom: 45, strony: 101796), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.scr.2020.101796 - link to the publication
  10. Strategie wyciszania ekspresji zmutowanego genu w terapii choroby Huntingtona
    Authors:
    Fiszer A, Nowak B.
    Academic press:
    Postępy Biochemii (rok: 2020, tom: 66, strony: 45300), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2020_313 - link to the publication
  1. Ribosome meets RISC at expanded CAG repeat tract - allele-selective RNAi approach for therapy of polyglutamine diseases
    Authors:
    Joachimiak P, Ciesiolka A, Luzna A, Kozlowska A, Michalak M, Krzyzosiak WJ, Fiszer A
    Conference:
    FEBS OPEN BIO (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 6-11.07.2019
    Status:
    Published
  2. Mutant HTT mRNA as therapeutic target in allele-selective CAG repeat-directed RNAi approach and putative pathogenic agent in HD
    Authors:
    Agnieszka Fiszer, Łukasz Przybył, Magdalena Jazurek-Ciesiolka, Adam Ciesiolka, Paweł Joachimiak, Emilia Kozlowska, Michał Michalak, Paweł Świtonski, Magdalena Woźna-Wysocka, Agata Łużna, Włodzimierz Krzyżosiak
    Conference:
    EHDN Plenary Meeting (rok: 2018, ), Wydawca: Journal of Neurology Neurosurgery and Psychiatry
    Data:
    konferencja 14-16.09.2018
    Status:
    Published

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