Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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A mechanism for fetal membrane detachment in mares, and factors that might lead to membrane retention.

2012/07/D/NZ5/04290

Keywords:

horses retained placenta MHC I oxytocin prostaglandins receptors

Descriptors:

  • NZ5_2: Etiology of animal diseases
  • NZ5_4: Pathogenesis of animal diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Medycyny Weterynaryjnej

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Rapacz-Leonard 

Number of co-investigators in the project: 4

Call: SONATA 4 - announced on 2012-09-15

Amount awarded: 499 630 PLN

Project start date (Y-m-d): 2013-06-13

Project end date (Y-m-d): 2019-06-12

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop badawczy ZEISS Axio Imager.M2 (200 000 PLN)
  2. Zestaw do kriostatu HYRAX C50 op-D (85 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (9)
  1. The oxytocin-prostaglandins pathways in the horse (Equus caballus) placenta during pregnancy, physiological parturition, and parturition with fetal membrane retention
    Authors:
    Anna Raapacz-Leonard, Mark Leonard, Małgorzata Chmielewska-Krzesińska, Marta Siemieniuch, Tomasz Janowski
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 45303), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-59085-1 - link to the publication
  2. Major histocompatibility complex class I in the horse (Equus caballus) placenta during pregnancy and parturition
    Authors:
    Anna Rapacz-Leonard, Mark Leonard, Małgorzata Chmielewska-Krzesińska, Katarzyna Paździor-Czapula, Tomasz Janowski
    Academic press:
    Placenta (rok: 2018, tom: 74, strony: 36-46), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.placenta.2018.12.006 - link to the publication
  1. Classical Major Histocompatibility Complex class I expression is up-regulated in equine placenta tissues during pregnancy and down-regulated during parturition.
    Authors:
    Anna Rapacz-Leonard, Małgorzata Dąbrowska, Katarzyna Łosiewicz, Małgorzata Chmielewska-Krzesińska, Tomasz Janowski, Andrzej Raś
    Conference:
    Februartagung 2015 (rok: 2015, ), Wydawca: Reproduction in Domestic Animals
    Data:
    konferencja 2,2015
    Status:
    Published
  2. Prostaglandins production in heavy draft mares that retain fetal membranes and those that deliver fetal membranes physiologically
    Authors:
    A Rapacz-Leonard, M Dąbrowska, M Chmielewska-Krzesińska, M Siemieniuch, TE Janowski, K Paździor-Czapula
    Conference:
    International Conference on Biology and Pathology of Reproduction in Domestic Animals, Gdańsk (rok: 2015, ), Wydawca: PAN Olsztyn
    Data:
    konferencja Sept 28th-30th
    Status:
    Published
  3. Mechanizm odklejenia błon płodowych u klaczy, jako determinujący wystąpienie zatrzymania łożyska u tych zwierząt
    Authors:
    A. Rapacz-Leonard
    Conference:
    I Sympozjum: Zdrowe Zwierzę-Bezpieczna Żywność; XI Sympozjum: Genetyczne, Fizjologiczne i Środowiskowe Uwarunkowania Rozrodu i Zdrowia Zwierząt oraz Bezpieczeństwa i Jakości Żywności Pochodzenia Zwierzęcego (rok: 2017, ), Wydawca: UWM
    Data:
    konferencja 11-13.06.
    Status:
    Published
  4. Prostaglandins E2 (PGE2) and F2a (PGF2a) and their synthetases (PGES and PGFS) during pregnancy and parturition in the horse.
    Authors:
    Anna Rapacz-Leonard, Małgorzata Dąbrowska, Małgorzata Chmielewska-Krzesińska, Marta Siemieniuch, Tomasz Janowski, Andrzej Raś, Katarzyna Paździor-Czapula
    Conference:
    ESDAR 2015 (rok: 2015, ), Wydawca: Reproduction in Domestic Animals
    Data:
    konferencja 9,2015
    Status:
    Published
  5. Does equine fetus express Major Histocompability Complex Class I (MHC I) only of maternal origin?
    Authors:
    J. Jaworska, A. Rapacz-Leonard, M. Dąbrowska, T. Janowski
    Conference:
    ESDAR 2016 (rok: 2016, ), Wydawca: Reproduction in Domestic Animals
    Data:
    konferencja 27-29.10.
    Status:
    Published
  6. Does equine fetus express only maternally inherited Major Histocompatibility Complex I (MHC I) in order to protect long lasting pregnancy?
    Authors:
    A Jaworska, A Rapacz-Leonard, TE Janowski
    Conference:
    International Conference on Biology and Pathology of Reproduction in Domestic Animals, Gdańsk (rok: 2015, ), Wydawca: PAN Olsztyn
    Data:
    konferencja Sept 28th-30th
    Status:
    Published
  7. Expression of Equine major Histocompatibility Complex Class I during Pregnancy, Parturition and fetal Membrane Retention
    Authors:
    A Rapacz-Leonard, M Dąbrowska, M Chmielewska-Krzesińska
    Conference:
    International Conference on Biology and Pathology of Reproduction in Domestic Animals, Gdańsk (rok: 2015, ), Wydawca: PAN Olsztyn
    Data:
    konferencja Sept 28th-30th
    Status:
    Published
  8. Heavy mares that retain fetal membranes and those that deliver fetal membranes physiologically differ in production of PGF2α and PGE2
    Authors:
    A. Rapacz-Leonard, M. Dąbrowska, M. Chmielewska- Krzesińska, K. Paździor-Czapula, M. Siemieniuch, T. Janowski
    Conference:
    ESDAR 2016 (rok: 2016, ), Wydawca: Reproduction in Domestic Animals
    Data:
    konferencja 27-29.10.
    Status:
    Published
  9. Should oxytocin be the first choice treatment for heavy draft mares that retained fetal membranes?
    Authors:
    A. Rapacz-Leonard, M. Dąbrowska, M. Chmielewska-Krzesińska, A. Raś, J. Całka, T. E. Janowski
    Conference:
    Februartagung 2016 (rok: 2016, ), Wydawca: DVG i Reproduction in Domestic Animals
    Data:
    konferencja Feb 10th-12th
    Status:
    Published