Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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IDENTIFICATION OF NEW CANCER-RELATED GENES THAT PLAY AN IMPORTANT ROLE IN COMMON HUMAN CANCERS

2011/01/B/NZ5/02773

Keywords:

CNV copy number variations oncogenes tumor suppressors MLPA somatic mutations

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ5_5: Diagnostics in human diseases
  • NZ2_11: Genetic epidemiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Politechnika Poznańska, Wydział Informatyki

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Kozłowski 

Number of co-investigators in the project: 8

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 746 200 PLN

Project start date (Y-m-d): 2011-12-06

Project end date (Y-m-d): 2016-07-05

Project duration:: 55 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw do elektroforezy poziomej.
  2. Zestaw komputerowy (7 000 PLN)
  3. Termocykler (2 szt.) (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (6)
  1. Copy number polymorphism in plant genomes
    Authors:
    Zmienko A, Samelak A, Kozlowski P, Figlerowicz M
    Academic press:
    Theoretical and Applied Genetics (rok: 2014, tom: 127, strony: 45309), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00122-013-2177-7 - link to the publication
  2. Oncogenomic portals for the visualization and analysis of genome-wide cancer data
    Authors:
    Klonowska K, Czubak K, Wojciechowska M, Handschuh L, Zmienko A, Figlerowicz M, Dams-Kozlowska H, Kozlowski P
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 176-192), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.6128. - link to the publication
  3. The Use of a Two-Tiered Testing Strategy for the Simultaneous Detection of Small EGFR Mutations and EGFR Amplification in Lung Cancer
    Authors:
    Lewandowska MA, Czubak K, Klonowska K, Jozwicki W, Kowalewski J, Kozlowski P
    Academic press:
    PLoS One (rok: 2015, tom: 10, strony: 45304), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0117983 - link to the publication
  4. Unpredictable changes of selected miRNA in expression profile of HNSCC
    Authors:
    Lamperska KM, Kozlowski P, Kolenda T, Teresiak A, Blizniak R, Przybyla W, Masternak MM, Golusinski P, Golusinski W
    Academic press:
    Cancer Biomarkers (rok: 2016, tom: 16, strony: 55-64), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/CBM-150540 - link to the publication
  5. Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative)
    Authors:
    Marcinkowska-Swojak M, Szczerbal I, Pausch H, Nowacka-Woszuk J, Flisikowski K, Dzimira S, Nizanski W, Payan-Carreira R, Fries R, Kozlowski P, Switonski M
    Academic press:
    Scientific Reports (rok: 2015, tom: 5, strony: 14696), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep14696 - link to the publication
  6. Copy number variation of genes involved in the hepatitis C virus-human interactome
    Authors:
    Budzko L, Marcinkowska-Swojak M, Jackowiak P, Kozlowski P, Figlerowicz M
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: 31340), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep31340 - link to the publication
  7. Genetic predisposition to breast and/or ovarian cancer – focus on the candidate BARD1 gene
    Authors:
    Klnowska K, Ratajska M, Wojciechowsak M, Kozlowski P
    Academic press:
    BioTechnologia Journal of Biotechnology, Computational Biology and Bionanotechnology (rok: 2014, tom: 95, strony: 203-214), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/bta.2014.54796 - link to the publication
  8. High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer
    Authors:
    Czubak K, Lewandowska MA, Klonowska K, Roszkowski K, Kowalewski J, Figlerowicz M, Kozlowski P
    Academic press:
    Oncotarget (rok: 2015, tom: 6, strony: 23399-23416), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.4351 - link to the publication
  9. An MLPA-based approach for high-resolution genotyping of disease-related multi-allelic CNVs
    Authors:
    Marcinkowska-Swojak M, Klonowska K, Figlerowicz M, Kozlowski P
    Academic press:
    Gene (rok: 2014, tom: 546, strony: 257-262), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2014.05.072 - link to the publication
  10. Analysis of large mutations in BARD1 in patients with breast and/or ovarian cancer: the Polish population as an example
    Authors:
    Klonowska K, Ratajska M, Czubak K, Kuzniacka A, Brozek I, Koczkowska M, Sniadecki M, Debniak J, Wydra D, Balut M, Stukan M, Zmienko A, Nowakowska B, Irminger-Finger I, Limon J, Kozlowski P
    Academic press:
    Scientific Reports (rok: 2015, tom: 5, strony: 10424), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep10424 - link to the publication
  11. An MLPA-based strategy for discrete CNV genotyping: CNV-miRNAs as an example
    Authors:
    Marcinkowska-Swojak M, Uszczynska B, Figlerowicz M, Kozlowski P
    Academic press:
    Human Mutation (rok: 2013, tom: 34, strony: 763-773), Wydawca: Wiley Periodicals Inc.
    Status:
    Published
    DOI:
    10.1002/humu.22288 - link to the publication
  12. Cancer predisposing BARD1 mutations affect exon skipping and are associated with overexpression of specific BARD1 isoforms.
    Authors:
    Ratajska M, Matusiak M, Kuzniacka A, Wasag B, Brozek I, Biernat W, Koczkowska M, Debniak J, Sniadecki M, Kozlowski P, Klonowska K, Pilyugin M, Wydra D, Laurent G, Limon J, Irminger-Finger I
    Academic press:
    Oncology Reports (rok: 2015, tom: 34, strony: 2609-2617), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/or.2015.4235 - link to the publication
  13. Analysis of boutique arrays: A universal method for the selection of the optimal data normalization procedure
    Authors:
    Uszczyńska B, Zyprych-Walczak J, Handschuh L, Szabelska A, Kaźmierczak M, Woronowicz W, Kozłowski P, Sikorski MM, Komarnicki M, Siatkowski I, Figlerowicz M
    Academic press:
    International Journal of Molecular Medicine (rok: 2013, tom: 32, strony: 668-684), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijmm.2013.1443 - link to the publication
  14. Simultaneous detection of mutations and copy number variation of NPM1 in the acute myeloid leukemia using multiplex ligation-dependent probe amplification
    Authors:
    Marcinkowska-Swojak M, Handschuh L, Wojciechowski P, Goralski M, Tomaszewski K, Kazmierczak M, Lewandowski K, Komarnicki M, Blazewicz J, Figlerowicz M, Kozlowski P
    Academic press:
    Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis (rok: 2016, tom: 786, strony: 14-26), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrfmmm.2016.02.001 - link to the publication
  1. Analiza dużych mutacji w genie BARD1 u pacjentek z rakiem piersi i/lub jajnika
    Authors:
    Klonowska K, Ratajska M, Kuzniacka A, Limon J, Czubak K, Kozlowski P
    Conference:
    VI Kongres Współczesnej Onkologii – "Next Generation" - Poznan 2014 (rok: 2014, ), Wydawca: Termedia
    Data:
    konferencja 27-29 marzec
    Status:
    Published
  2. MLPA-based strategy for discrete CNV genotyping: CNV-miRNAs as an example
    Authors:
    Marcinkowska M, Kozlowski P
    Conference:
    62nd Annual Meeting of The American Society of Human Genetics - San Francisco 2012 (rok: 2012, ), Wydawca: American Society of Human Genetics
    Data:
    konferencja 6-10 listopad
    Status:
    Published
    DOI:
    link to the publication
  3. Copy number polymorphism of microRNA Genes
    Authors:
    Kozlowski P, Marcinkowska M
    Conference:
    RNA Biology Cold Spring Harbor Asia (rok: 2012, ), Wydawca: Cold Spring Harbor Laboratory
    Data:
    konferencja 8-12 październik
    Status:
    Published
  4. Analiza liczby kopii wybranych genów mikroRNA i genów związanych z biogenezą mikroRNA w raku płuca
    Authors:
    Czubak K, Lewandowska MA, Jozwicki W, Kowalewski W, Klonowska K, Kozlowski P
    Conference:
    VI Kongres Współczesnej Onkologii – "Next Generation" - Poznan 2014 (rok: 2014, ), Wydawca: Termedia
    Data:
    konferencja 27-29 marzec
    Status:
    Published
  5. Analysis of Large Mutations in BARD1 Gene in Patients with Breast and/or Ovarian Cancer
    Authors:
    Klonowska K, Ratajska M, Kuzniacka A, Brozek I, Kozlowski P, Limon J
    Conference:
    The 5th International Symposium on Hereditary Breast and Ovarian Cancer – BRCA: Twenty Years of Advances" Montreal 2014 (rok: 2014, ), Wydawca: Multimed Inc
    Data:
    konferencja 23-25 kwiecień
    Status:
    Published
  6. Detection of leukemia-specific NPM1 mutations with the use of three different approaches
    Authors:
    Handschuh L Marcinkowska-Swojak M, Tomaszewski K, Wojciechowski P, Goralski M, Kazmierczak M, Komarnicki M, Figlerowicz M, Kozlowski P
    Conference:
    BIO 2014 - Warsaw (rok: 2014, ), Wydawca: Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 9-12 wrzesień
    Status:
    Published

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