Projects funded by the NCN

Functional analysis of SLC35A transporter family - substrate specificity and ability to interact with other proteins in ...

Call: OPUS 8 , Panel: NZ3

Principal investigator: prof. Mariusz Olczak

Uniwersytet Wrocławski, Wydział Biotechnologii

Tailored fluorogenic substrate library with natural / unnatural amino acids in search for specific substrates of matrix ...

Call: OPUS 7 , Panel: ST5

Principal investigator: dr hab. Marcin Drąg

Politechnika Wrocławska, Wydział Chemiczny

Structure optimization of inhibitor for paracaspase MALT1

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: dr Paulina Kasperkiewicz

Politechnika Wrocławska, Wydział Chemiczny

Aminopeptidases activity profiling in lysates of cell line HeLa using library of fluorogenic substrates

Call: PRELUDIUM 5 , Panel: NZ1

Principal investigator: dr Anna Byzia

Politechnika Wrocławska, Wydział Chemiczny

Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Michał Zdżalik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

Call: SYMFONIA 1 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

CleavEx - universal system for natural aminoacid sequence exposition for proteolytic enzymes specificity analysis

Call: PRELUDIUM 4 , Panel: NZ1

Principal investigator: dr Karolina Płaza

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

Call: SONATA 18 , Panel: NZ6

Principal investigator: dr Wioletta Rut

Politechnika Wrocławska

Combinatorial library of fluorogenic substrates containing natural / unnatural amino acids for substrate specificity pro...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Marcin Drąg

Politechnika Wrocławska, Wydział Chemiczny

Hybrid human SUMO proteins for selective detection and labelling of SENP proteases

Call: OPUS 21 , Panel: ST4

Principal investigator: dr Wioletta Rut

Politechnika Wrocławska

Insights into substrate specificity of the noncanonical cytoplasmic poly(A) polymerase TENT5C in B lymphocytes

Call: PRELUDIUM 19 , Panel: NZ2

Principal investigator: Aleksandra Bilska

Uniwersytet Warszawski, Wydział Biologii

Novel mechanisms of PAD activity regulation. Substrate specificity and activation of peptidyl arginine deiminase in the ...

Call: GRIEG 1 , Panel: NZ1

Principal investigator: dr Tomasz Kantyka

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

Call: HARMONIA 1 , Panel: NZ1

Principal investigator: prof. Barbara Tudek

Instytut Biochemii i Biofizyki PAN

Substrate specificity of LPCATs from photosynthetic oleaginous microalgae in forward and reverse reactions and character...

Call: SHENG 1 , Panel: NZ3

Principal investigator: prof. Antoni Banaś

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

An integrated screening platform for determination of human proteasomes extended substrate specificity

Call: OPUS 13 , Panel: ST5

Principal investigator: prof. Marcin Drąg

Politechnika Wrocławska

Computational investigation of the dynamic and physico-chemical properties of pteridine reductase 1 of human trypanosoma...

Call: SONATA 11 , Panel: NZ1

Principal investigator: dr Joanna Panecka-Hofman

Uniwersytet Warszawski, Wydział Fizyki

Phosphorylation of the A/B domain as the crucial mechanism involved in substrate specificity of the two isoforms (RORgam...

Call: OPUS 10 , Panel: NZ7

Principal investigator: dr Marcin Ratajewski

Instytut Biologii Medycznej Polskiej Akademii Nauk

Reversible modification of enzyme activity and substrate specificity by engineering of the ligand exchange pathways

Call: HARMONIA 7 , Panel: NZ1

Principal investigator: dr Artur Góra

Politechnika Śląska, Centrum Biotechnologii