Projects funded by the NCN

Understanding the mechanism of action for small molecule kinase inhibitors in alleviating myotonic dystrophy type 1 (DM1...

Call: OPUS 7 , Panel: NZ5

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej PAN

Novel polyelectrolytes as potential inhibitors of HSV-1 virus - synthesis, properties and mechanism of action

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Transient protein states in designing small-molecule inhibitors of protein-protein interactions

Call: SYMFONIA 2 , Panel: NZ1

Principal investigator: prof. Tadeusz Holak

Uniwersytet Jagielloński, Wydział Chemii

Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

Call: SONATA BIS 3 , Panel: NZ5

Principal investigator: prof. Dominika Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Compounds modulating function of telomeric proteins TRF1 and TRF2

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Maciej Bagiński

Politechnika Gdańska, Wydział Chemiczny

Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr hab. Magdalena Stobiecka

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Ireneusz Majsterek

Uniwersytet Medyczny w Łodzi

The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Magdalena Żarnik

Uniwersytet Jagielloński, Wydział Chemii

Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

Call: OPUS 20 , Panel: NZ3

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Ewa Surmiak

Uniwersytet Jagielloński, Wydział Chemii

De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Łukasz Berlicki

Politechnika Wrocławska

Polymeric inhibitors of Zika virus

Call: OPUS 14 , Panel: ST5

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Small-molecule inhibitors for characterization of the interaction between extracellular domains of Programmed Cell Death...

Call: MAESTRO 9 , Panel: ST5

Principal investigator: prof. Tadeusz Holak

Uniwersytet Jagielloński, Wydział Chemii

Design of new small molecular regulators (inhibitors, activators) of the catalytic activity of adenylate kinases. Molecu...

Call: OPUS 13 , Panel: ST4

Principal investigator: dr Anna Kozakiewicz-Piekarz

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Chemii

Exploring Baltic Sea cyanobacteria for small-molecule inhibitors of microRNA function

Call: OPUS 13 , Panel: NZ9

Principal investigator: prof. Paweł Brzuzan

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Geoinżynierii

Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the colorectal cancer treatment

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Adam Dziki

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Analysis of the effectiveness of anticancer activity of tyrosine kinase inhibitors combined with nanoparticles in in vit...

Call: SONATA 11 , Panel: ST4

Principal investigator: dr Natalia Piergies

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego Polskiej Akademii Nauk

Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the primary open-angle glaucoma treatmen...

Call: OPUS 11 , Panel: NZ5

Principal investigator: prof. Ireneusz Majsterek

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Discovery and development of small-molecule inhibitors of USP2 for targeted, non-genotoxic therapy of cancer

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Tadeusz Holak

UNIWERSYTET JAGIELLOŃSKI, Wydział Chemii

Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Maria Bretner

Politechnika Warszawska, Wydział Chemiczny

New MOF compounds as degradable nanocontainers of tyrosine kinases inhibitors in novel anti-cancer therapy

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Artur Terzyk

Uniwersytet Mikołaja Kopernika, Wydział Chemii