Projects funded by the NCN

Analysis of selected physicochemical, biological and pharmacological properties of biomedical materials modified by synt...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: dr Katarzyna Szałapata

Uniwersytet Marii Curie-Skłodowskiej, Wydział Biologii i Biotechnologii

The search for novel human proteasome inhibitors and fluorogenic substrates.

Call: SONATA 1 , Panel: ST5

Principal investigator: dr Dawid Dębowski

Uniwersytet Gdański, Wydział Chemii

Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Maciej Walczak

Politechnika Wrocławska, Wydział Chemiczny

Design and synthesis of selective and irreversible inhibitors of HAT protease.

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Marcin Skoreński

Politechnika Wrocławska, Wydział Chemiczny

Phosphonic inhibitors of human neutrophil elastase in cancer therapy

Call: SONATA 5 , Panel: NZ4

Principal investigator: dr Łukasz Winiarski

Politechnika Wrocławska, Wydział Chemiczny

Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Michał Zdżalik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

Call: SYMFONIA 1 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Effect of deimination of essential arginine residues on the function of protease inhibitors and other components of inna...

Call: OPUS 3 , Panel: NZ6

Principal investigator: dr Tomasz Kantyka

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

The structures, biochemistry, physiology, and evolution of bacterial α2-macroglobulins from the human periodontopathogen...

Call: SONATA BIS 11 , Panel: NZ1

Principal investigator: dr Mirosław Książek

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

The study of adsorption mechanisms of N-benzenamino(boronphenyl)methylphosphonic acids on different metal surfaces

Call: PRELUDIUM 2 , Panel: ST4

Principal investigator: dr Natalia Piergies

Uniwersytet Jagielloński, Wydział Chemii

Defining the interplay between SLPI and the IL-1 family cytokines in the immune response

Call: SONATA 16 , Panel: NZ6

Principal investigator: dr Ewa Oleszycka

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Role of cereal leaf beetle – associated bacteria in the adaptation of their insect host to the insecticides and protease...

Call: PRELUDIUM 19 , Panel: NZ9

Principal investigator: Beata Wielkopolan

Instytut Ochrony Roślin - Państwowy Instytut Badawczy

Exploring the allosteric regulation of the SARS CoV-2 hydrolases using methyl-TROSY NMR spectroscopy - in search of nove...

Call: OPUS 19 , Panel: ST4

Principal investigator: prof. Wiktor Koźmiński

Uniwersytet Warszawski, Wydział Chemii

SufA bacterial protease inhibitors as potential diagnostic tools and antibacterial agents.

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Ewa Burchacka

Politechnika Wrocławska

Inhibitors of serine proteases as regulators of dendritic cell function.

Call: MAESTRO 1 , Panel: NZ5

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Effects of proteasome inhibition on mitochondrial homeostasis.

Call: OPUS 17 , Panel: NZ5

Principal investigator: prof. Agnieszka Chacińska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

Call: OPUS 15 , Panel: NZ6

Principal investigator: dr hab. Marcin Sieńczyk

Politechnika Wrocławska

Association of TXNDC5 and calreticulin with decreased ER stress, allowing resistant multiple myeloma cells to by-pass pr...

Call: PRELUDIUM 15 , Panel: NZ5

Principal investigator: Tadeusz Kubicki

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

Novel inhibitors of herpes virus protease

Call: PRELUDIUM 14 , Panel: NZ6

Principal investigator: Magdalena Pachota

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome i...

Call: OPUS 13 , Panel: NZ6

Principal investigator: prof. Jakub Gołąb

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Proteomic analysis of myeloma plasma cells to determine proteins and pathways involved in acquired resistance to proteas...

Call: OPUS 13 , Panel: NZ5

Principal investigator: dr hab. Dominik Dytfeld

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

SLPI-dependent cutaneous antimicrobial and antiviral immunity.

Call: OPUS 13 , Panel: NZ6

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Allosteric inhibitors of proteasome - optimization of the structure of PR39 analogs in order to achieve greater efficien...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Małgorzata Giżyńska

Uniwersytet Gdański, Wydział Chemii

Evaluation of primary and secondary molecular disorders determinig drug resistance from a group of proteasome inhibitors...

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Tadeusz Robak

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

SLPI - novel regulator involved in the neuro-immune interplay in psoriasis

Call: SONATA 12 , Panel: NZ6

Principal investigator: dr Beata Grygier

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Zika virus NS3 protease

Call: OPUS 11 , Panel: NZ6

Principal investigator: dr hab. Krzysztof Pyrć

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Structure and function characterization of newly discovered unique inhibitors of proteases

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Discovery and development of small-molecule inhibitors of USP2 for targeted, non-genotoxic therapy of cancer

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Tadeusz Holak

UNIWERSYTET JAGIELLOŃSKI, Wydział Chemii

Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the ...

Call: PRELUDIUM 9 , Panel: NZ1

Principal investigator: Julia Witkowska

Uniwersytet Gdański, Wydział Chemii

Investigation of the antitumor potential of stimulator of interferon genes (STING) - an adaptor protein in innate immune...

Call: PRELUDIUM 9 , Panel: NZ6

Principal investigator: Olga Sokołowska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego