Projects funded by the NCN

Effects of proteasome inhibition on mitochondrial homeostasis.

Call: OPUS 17 , Panel: NZ5

Principal investigator: prof. Agnieszka Małgorzata Chacińska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Association of TXNDC5 and calreticulin with decreased ER stress, allowing resistant multiple myeloma cells to by-pass pr...

Call: PRELUDIUM 15 , Panel: NZ5

Principal investigator: Tadeusz Franciszek Kubicki

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

Determination of arginase-1 as a potential drug target in the treatment of multiple myeloma and in reducing proteasome i...

Call: OPUS 13 , Panel: NZ6

Principal investigator: prof. Jakub Adam Gołąb

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Proteomic analysis of myeloma plasma cells to determine proteins and pathways involved in acquired resistance to proteas...

Call: OPUS 13 , Panel: NZ5

Principal investigator: dr Dominik Dytfeld

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Allosteric inhibitors of proteasome - optimization of the structure of PR39 analogs in order to achieve greater efficien...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Małgorzata Giżyńska

Uniwersytet Gdański, Wydział Chemii

Evaluation of primary and secondary molecular disorders determinig drug resistance from a group of proteasome inhibitors...

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Tadeusz Jerzy Robak

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the ...

Call: PRELUDIUM 9 , Panel: NZ1

Principal investigator: Julia Witkowska

Uniwersytet Gdański, Wydział Chemii

Investigation of the antitumor potential of stimulator of interferon genes (STING) - an adaptor protein in innate immune...

Call: PRELUDIUM 9 , Panel: NZ6

Principal investigator: Olga Sokołowska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Discovery and development of small-molecule inhibitors of USP2 for targeted, non-genotoxic therapy of cancer

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

The search for novel human proteasome inhibitors and fluorogenic substrates.

Call: SONATA 1 , Panel: ST5

Principal investigator: dr Dawid Dębowski

Uniwersytet Gdański, Wydział Chemii