Projects funded by the NCN

Optimization of the substrates structure to study deubiquitinating enzymes using methods of combinatorial chemistry

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Wioletta Rut

Politechnika Wrocławska, Wydział Chemiczny, Zakład Chemii Bioorganicznej

Synthesis of fluorogenic substrates, inhibitors and activity-based probes of human neutrophil proteinase NSP4 and its ev...

Call: OPUS 8 , Panel: ST5

Principal investigator: prof. Adam Lesner

Uniwersytet Gdański, Wydział Chemii

Tailored fluorogenic substrate library with natural / unnatural amino acids in search for specific substrates of matrix ...

Call: OPUS 7 , Panel: ST5

Principal investigator: dr hab. Marcin Drąg

Politechnika Wrocławska, Wydział Chemiczny

The search for novel human proteasome inhibitors and fluorogenic substrates.

Call: SONATA 1 , Panel: ST5

Principal investigator: dr Dawid Dębowski

Uniwersytet Gdański, Wydział Chemii

Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Michał Zdżalik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Unnatural amino acids as a tool for optimization of substrates architecture for targeting human cysteine protease, cathe...

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: dr Marcin Poręba

Politechnika Wrocławska, Wydział Chemiczny

Biochemical and physiological characterization of human protease HtrA3

Call: OPUS 5 , Panel: NZ1

Principal investigator: prof. Barbara Lipińska

Uniwersytet Gdański, Wydział Biologii

Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

Call: SYMFONIA 1 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Fluorescent substrates of neutrophil proteinases: design, chemical synthesis , selection by the combinatorial chemistry ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Jadwiga Popow - Stellmaszyk

Uniwersytet Gdański, Wydział Chemii

CleavEx - universal system for natural aminoacid sequence exposition for proteolytic enzymes specificity analysis

Call: PRELUDIUM 4 , Panel: NZ1

Principal investigator: dr Karolina Płaza

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Macrocyclic peptides for targeting of membrane-anchored serine protease

Call: PRELUDIUM BIS 5 , Panel: NZ7

Principal investigator: dr hab. Paulina Kasperkiewicz-Wasilewska

Politechnika Wrocławska

Biological membranes and macromolecular crowding in the function of the hepatitis C virus proteases

Call: PRELUDIUM BIS 4 , Panel: NZ1

Principal investigator: prof. Joanna Trylska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Hybrid human SUMO proteins for selective detection and labelling of SENP proteases

Call: OPUS 21 , Panel: ST4

Principal investigator: dr Wioletta Rut

Politechnika Wrocławska

Identification of natural substrates and physiological partners of mitochondrial AtFtsH4 protease from Arabidopsis thali...

Call: PRELUDIUM 2 , Panel: NZ2

Principal investigator: dr Elwira Smakowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Living on the edge: evolutionary adaptation of substrate-recruiting subunits of the cullin-RING ubiquitin ligase complex...

Call: PRELUDIUM 20 , Panel: NZ1

Principal investigator: Natalia Szulc

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

Call: OPUS 15 , Panel: NZ6

Principal investigator: dr hab. Marcin Sieńczyk

Politechnika Wrocławska

An integrated screening platform for determination of human proteasomes extended substrate specificity

Call: OPUS 13 , Panel: ST5

Principal investigator: prof. Marcin Drąg

Politechnika Wrocławska

The role of the HtrA protein in the Helicobacter pylori cell

Call: OPUS 11 , Panel: NZ2

Principal investigator: prof. Joanna Skórko-Glonek

Uniwersytet Gdański, Wydział Biologii

Combinatorial peptide libraries modified by ionization tags on solid support for investigation of new substrates of prot...

Call: SONATA 9 , Panel: ST5

Principal investigator: dr Remigiusz Bąchor

Uniwersytet Wrocławski, Wydział Chemii