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Unnatural amino acids as a tool for optimization of substrates architecture for targeting human cysteine protease, cathepsin L.

2013/09/N/ST5/02448

Keywords:

protease cathepsin L unnatural amino acids fluorogenic substrate library

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Poręba 

Number of co-investigators in the project: 2

Call: PRELUDIUM 5 - announced on 2013-03-15

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2014-04-04

Project end date (Y-m-d): 2015-11-30

Project duration:: 20 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (3)
  1. Selective imaging of human cathepsin L in breast cancer by fluorescent activity-based probes
    Authors:
    Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M
    Academic press:
    Chemical Science (rok: 2018, ), Wydawca: Royal Society of Chemistry
    Status:
    Accepted for publication
    DOI:
    10.1039/c7sc04303a - link to the publication
  1. HyCoSuL approach of the optimization of cathepsin L substrate specificity
    Authors:
    Poreba M, Kasperkiewicz P, Turk B, Drag M
    Conference:
    XXXII Winter School on Proteinases and Their Inhibitors (rok: 2015, ), Wydawca: Salzburg Universitat
    Data:
    konferencja 25 lutego - 03 marca
    Status:
    Published
  2. Zastosowanie nienaturalnych aminokwasów w bibliotekach substratów fluorogenicznych do badania enzymów proteolitycznych
    Authors:
    Poreba M, Kasperkiewicz P, Rut W, Snipas S, Mihelic M, Turk B, Salvesen G, Drag M
    Conference:
    II Ogólnopolskie Sympozium Interdyscyplinarne, Inter-Mix 2014 (rok: 2014, ), Wydawca: Klub Stypendystów Fundacji na Rzecz Nauki Polskiej
    Data:
    konferencja 20-23 listopada 2014
    Status:
    Published
  3. Specific labeling of cathepsins B and L in cancer cells using fluorescent activity based probes
    Authors:
    Poreba M, Rut W, Groborz K, Kasperkiewicz P, Vizovisek M, Finlay D, Turk D, Turk B, Salvesen GS, Drag M
    Conference:
    XXXIVth Winter School on Proteinases and Their Inhibitors (rok: 2017, ), Wydawca: Salzburg Universitat
    Data:
    konferencja 8 - 12 marca
    Status:
    Published

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