Projects funded by the NCN

Targeting MMP-9 in Cancer Treatment: Computational Design and Experimental Validation of Potent, Safe Antitumor Agents

Call: SONATA BIS 15 , Panel: ST5

Principal investigator: dr Anna Żądło-Dobrowolska

Instytut Chemii Organicznej Polska Akademia Nauk

Smart Multiscale Encapsulation System: Hydrogel Macrocapsules with LbL Nanoparticles for Colorectal Cancer Treatment

Call: PRELUDIUM 24 , Panel: ST11

Principal investigator: Joanna Irena Szechyńska

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

New aryl difluoromethylenephosphonic acid and thiazole conjugates as effective PTP1B inhibitors used in the treatment of...

Call: PRELUDIUM 24 , Panel: ST5

Principal investigator: Dominika Agnieszka Kołodziej-Sobczak

Uniwersytet Mikołaja Kopernika

Artificial intelligence in predicting treatment outcomes of abdominal cancers – implementation of machine learning and d...

Call: SONATINA 9 , Panel: NZ7

Principal investigator: dr Krzysztof Bartnik

Politechnika Warszawska

Next-Generation Exosome Therapy: Engineering NK Cell-Derived Vesicles for Targeted Cancer Treatment

Call: SONATINA 9 , Panel: NZ6

Principal investigator: dr Daria Nawrocka

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Developing histone deacetylase-inhibiting hybrid analogs of pleurocidin and their potential in the treatment of HPV-indu...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr hab. Ewelina Piktel

Uniwersytet Medyczny w Białymstoku

Non-canonical Estrogen Receptor (ER) signalling in breast cancer progression

Call: OPUS 28 , Panel: NZ3

Principal investigator: prof. Rafał Sebastian Sądej

Gdański Uniwersytet Medyczny

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Bacterial membrane carriers targeting tumor-associated microbes for advanced cancer therapy

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Monika Kluzek

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr Tomasz Krzysztof Prajsnar

Uniwersytet Jagielloński, Wydział Biologii

Advanced statistical and deep learning models to predict cancer risk and support treatment decisions

Call: SONATA BIS 13 , Panel: NZ2

Principal investigator: dr Michał Marczyk

Politechnika Śląska, Wydział Automatyki, Elektroniki i Informatyki

Extensive analysis of the immunological profile of pediatric patients with acute lymphoblastic leukemia in order to iden...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Anna Krętowska-Grunwald

Uniwersytet Medyczny w Białymstoku

Anticancer potential of TMPyP4 porphyrin in breast cancer photodynamic therapy and evaluation of the treatment safety

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Błażej Rubiś

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Multifunctional emulsion-based transporters for personalised cancer treatment

Call: OPUS 25 , Panel: ST8

Principal investigator: prof. Ewa Dłuska

Politechnika Warszawska, Wydział Inżynierii Chemicznej i Procesowej

Chiral hybrids of quinones and quinols with double anticancer and antimicrobial activity against drug-resistant pathogen...

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Ryszard Józef Ostaszewski

Instytut Chemii Organicznej Polska Akademia Nauk

Precise molecular characterization of circulating tumour cells in patients with triple negative breast cancer using high...

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Stefano Volinia

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

Histone demethylase inhibitors as chemosensitivity modulators in the treatment of head and neck squamous cell carcinoma

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Dawid Dariusz Dorna

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Katarzyna Joanna Dziubek

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Katarzyna Florczak-Substyk

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Targeting of HSF1 as a therapeutic approach to inhibit the progression of hormone-dependent breast cancer.

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Natalia Vydra

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

Improvement of therapeutic safety of parenteral nutrition in cancer patients - the interplay between supportive drugs an...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Szymon Tomczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

New type of analogs and conjugates of folic acid with potential therapeutic applicaton in treatment of hormone-dependent...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Olga Ciupak

Politechnika Gdańska, Wydział Chemiczny

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Exploring new roles for ADAR1 in cancer; generation of novel neoantigens, links with p53 and the effects of cancer treat...

Call: WEAVE-UNISONO , Panel: NZ2

Principal investigator: dr Małgorzata Kurkowiak

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

Tryptophan Metabolites and their Metal Complexes as new drugs for Colorectal Cancer Treatment and Human Gut Microbiota R...

Call: OPUS 20 , Panel: ST4

Principal investigator: prof. Beata Izabella Godlewska-Żyłkiewicz

Uniwersytet w Białymstoku, Wydział Chemii

Photodynamic therapy combined with PD-1/PD-L1 blockade immunotherapy: new possibilities for the treatment of immunogenic...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr hab. Janusz Marcin Dąbrowski

Uniwersytet Jagielloński, Wydział Chemii

Modulation of exosome production to support anti-cancer treatment

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr Liliana Monika Czernek

Centrum Badań Molekularnych i Makromolekularnych PAN

Curcuminoid-polyphenol conjugates as potential therapeutics for urinary system cancer treatment

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Tomasz Adam Gośliński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Quantitative analysis of ultrasound scattered in the tissue. Application in assessing tumor response to chemotherapy in ...

Call: OPUS 18 , Panel: ST7

Principal investigator: prof. Jerzy Litniewski

Instytut Podstawowych Problemów Techniki Polska Akademia Nauk

The [60]fullerene-based theranostic agent for pancreatic cancers treatment and diagnosis

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Maciej Michał Serda

UNIWERSYTET ŚLĄSKI, Wydział Nauk Ścisłych i Technicznych

Liposomal berberine and anti-CD47 antibody as an effective therapy for the treatment of colorectal cancer

Call: PRELUDIUM 17 , Panel: NZ5

Principal investigator: dr Martyna Maria Mianowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Development of new and more efficient treatment against mesothelioma utilizing oncolytic adenovirus armed with ICOS liga...

Call: SONATINA 3 , Panel: NZ7

Principal investigator: dr Łukasz Kuryk

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

Hypoxia in combinatory treatment of murine pancreatic tumor

Call: OPUS 15 , Panel: NZ5

Principal investigator: dr Martyna Krzykawska-Serda

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

New Hexokinase II inhibitors, in search of innovative therapeutic approaches to cancer treatment

Call: PRELUDIUM 14 , Panel: NZ7

Principal investigator: Mateusz Dawid Tomczyk

Politechnika Śląska, Wydział Chemiczny

Preparation and investigation of multifunctional biomaterials based on nanoapatites for possible application in bone tum...

Call: PRELUDIUM 14 , Panel: ST5

Principal investigator: dr Paulina Teresa Sobierajska

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego PAN

Combined urinary bladder cancer treatment with isothiocyanate-derived mercapturic acids and microtubule assembly modulat...

Call: SONATA 13 , Panel: NZ7

Principal investigator: dr Mateusz Psurski

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Molecular mechanism of action and therapeutic effect of 5-aza-2'-deoxycytidine and topoisomerase inhibitors combination ...

Call: OPUS 13 , Panel: NZ5

Principal investigator: dr hab. Wojciech Kałas

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Identification of the mechanism of antineoplastic activity of metformin, as an experimental approach to improve cancer t...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Jerzy Aleksander Pałka

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the colorectal cancer treatment

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Adam Janusz Dziki

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Effectiveness of anticancer activity of DMU-214 (3'-hydroxy-3,4,5,4'-tetrametoxystilbene) in personalized treatment for ...

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr hab. Hanna Helena Piotrowska-Kempisty

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Association of selected, inherited genetic factors with the effectiveness of treatment in head and neck squamous cell ca...

Call: OPUS 12 , Panel: NZ5

Principal investigator: dr hab. Dorota Monika Butkiewicz

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Emerging spectroscopic technologies in diagnosis and treatment of cancer by Raman-IR-SNOM-AFM-femtosecond scpectroscopy-...

Call: OPUS 10 , Panel: ST4

Principal investigator: prof. Halina Abramczyk

Politechnika Łódzka, Wydział Chemiczny

Co-dependence of cell-to-cell metabolite shuttles and macromolecular organization of metabolism in norm and pathology. Q...

Call: OPUS 10 , Panel: NZ1

Principal investigator: prof. Dariusz Stanisław Rakus

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

AP-1 : a novel player in the regulation of Senescence Associated Secretory Phenotype of cancer cells

Call: PRELUDIUM 10 , Panel: NZ3

Principal investigator: Anna Aneta Strzeszewska

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

SLC6A14 - an amino acid transporter upregulated in cancer: Role of chaperone proteins in transporter exit from endoplasm...

Call: OPUS 10 , Panel: NZ3

Principal investigator: prof. Katarzyna Anna Nałęcz

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Description of platelets role in metastasis and evaluation of anti-platelet treatment efficacy in mice model of metastat...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Elżbieta Buczek

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Study on the mechanism of cancer cell growth inhibition by synergistic activation of p53 protein caused by combined trea...

Call: OPUS 6 , Panel: NZ5

Principal investigator: dr hab. Marek Rusin

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

Study of the role of follicle stimulating hormone and its receptor in growth and putative treatment strategies for prost...

Call: PRELUDIUM 6 , Panel: NZ5

Principal investigator: Joanna Stelmaszewska

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

The role of endogenous opioid system in the pathogenesis and treatment of inflammatory bowel diseases and colitis-associ...

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: dr Marta Zielińska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Development of hyphenated analytical (capillary electrophoresis-inductively coupled plasma mass spectrometry) methodolog...

Call: PRELUDIUM 6 , Panel: ST4

Principal investigator: Magdalena Matczuk

Politechnika Warszawska, Wydział Chemiczny