Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Study on the mechanism of cancer cell growth inhibition by synergistic activation of p53 protein caused by combined treatment with nutlin-3a and substances inducing nucleolar stress.

2013/11/B/NZ5/03190

Keywords:

p53 nutlina-3a aktynomycyna D stress jąderkowy autofagia apoptoza

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ3_1: Cell biology
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marek Rusin 

Number of co-investigators in the project: 6

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 410 450 PLN

Project start date (Y-m-d): 2014-07-18

Project end date (Y-m-d): 2018-01-17

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw do elektroforezy i elektrotransferu białek z zasilaczem (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. PIM2 Survival Kinase Is Upregulated in a p53-dependent Manner in Cells Treated With Camptothecin or Co-Treated With Actinomycin D and nutlin-3a
    Authors:
    Artur Zajkowicz, Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok , Barbara Łasut, Marek Rusin
    Academic press:
    Arch Biochem Biophys (rok: 2018, tom: 655, strony: 26-36), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2018.08.005. - link to the publication
  2. Synergistic Activation of p53 by Actinomycin D and nutlin-3a Is Associated With the Upregulation of Crucial Regulators and Effectors of Innate Immunity
    Authors:
    Małgorzata Krześniak, Artur Zajkowicz, Agnieszka Gdowicz-Kłosok, Magdalena Głowala-Kosińska, Barbara Łasut-Szyszka, Marek Rusin
    Academic press:
    Cell Signal (rok: 2020, tom: 69, strony: 109552), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cellsig.2020.109552 - link to the publication
  3. Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.
    Authors:
    Zajkowicz A, Gdowicz-Kłosok A, Krześniak M, Ścieglińska D, Rusin M.
    Academic press:
    Cell Signal. (rok: 2015, tom: 27, strony: 1677-1687), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cellsig.2015.05.005. - link to the publication

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