Projects funded by the NCN

Estrogen receptor GPER as a modulator of inflammatory and functional gastrointestinal diseases and colorectal cancer

Call: PRELUDIUM 9 , Panel: NZ5

Principal investigator: Damian Jacenik

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Non-quinazoline antagonists of apha1 and 5-HT2A receptors with pleiotropic effects as a new perspective for hypertension...

Call: SONATA 8 , Panel: NZ7

Principal investigator: dr Monika Kubacka

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

New selective antagonists of ionotropic glutamate non-NMDA receptors

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr Ewa Szymańska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: dr Agnieszka Łupicka-Słowik

Politechnika Wrocławska, Wydział Chemiczny

Synthesis and marking the activity of new potential antagonists of receptors for excitatory amino acids which have the s...

Call: OPUS 1 , Panel: NZ4

Principal investigator: prof. Aleksander Mazurek

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Influence of antagonists (scopolamine and 3-quinuclidinyl benzilate) and agosists (carbachol) of muscarinic cholinergic ...

Call: PRELUDIUM 5 , Panel: NZ9

Principal investigator: Szymon Chowański

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

The effect of cytoplasmic incompatibility inducing Wolbachia on the detection of intralocus sexual conflict

Call: PRELUDIUM 5 , Panel: NZ8

Principal investigator: Eoin Duffy

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

Interactions between isolates of Potato virus Y (PVY) in mixed infections and their effects on the spatial distribution ...

Call: OPUS 5 , Panel: NZ9

Principal investigator: dr hab. Jerzy Syller

Instytut Hodowli i Aklimatyzacji Roślin - Państwowy Instytut Badawczy

Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric ...

Call: SONATA 4 , Panel: NZ1

Principal investigator: dr Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Studies on synergistic effects of selected phenols and polyphenols during peroxidation of model lipid systems.

Call: PRELUDIUM 3 , Panel: ST4

Principal investigator: Ewelina van Wenum

Uniwersytet Warszawski, Wydział Chemii

LCAP biomimetics - alicyclic amine derivatives as a new class of monoaminergic receptor ligands

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr hab. Paweł Zajdel

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: Jolanta Dyniewicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Conjugated linoleic acid (CLA)-induced transcriptional activation of PPAR-an investigation of molecular machanisms of pu...

Call: OPUS 2 , Panel: NZ9

Principal investigator: prof. Teresa Leszczyńska

Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Technologii Żywności

Analysis of the anti-nociceptive and anti-inflammatory action of histamine H4 receptor antagonist in inflammatory nocice...

Call: PRELUDIUM 2 , Panel: NZ4

Principal investigator: Przemysław Rzodkiewicz

Instytut Reumatologii im. prof. dr hab. med. Eleonory Reicher

Brain regions that mediate antipsychotic-induced changes in oscillatory activity recorded in the nucleus accumbens

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr Mark Hunt

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Targeting the serotonin 5-HT7 receptor in a search for new strategies of mental disorders treatment

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Patryk Pyka

Uniwersytet Jagielloński, Collegium Medicum

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Magdalena Białoń

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Dual 5-HT3 receptor/5-HT6 receptor antagonists in neuropsychiatric and neurological disorders

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Paweł Zajdel

Uniwersytet Jagielloński, Collegium Medicum

Opioid receptors in the basal ganglia of the brain as targets for alcohol abuse therapy.

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr Jan Rodriguez Parkitna

Instytut Farmakologii PAN

The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Magdalena Żarnik

Uniwersytet Jagielloński, Wydział Chemii

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Quinoxalino-2,3-diones as potent tools for exploration of ionotropic kainate receptors

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Ewa Szymańska

Uniwersytet Jagielloński, Collegium Medicum

Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Histamine H3/H4 receptors as the attractive target for the search of biologically active substances

Call: MAESTRO 1 , Panel: NZ4

Principal investigator: prof. Katarzyna Kieć-Kononowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Evaluation of the activity of MDM2-p53 antagonist RG7388 in mouse cancer models, alone and in combination with anti-PD-1...

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Aneta Wiśniewska

Uniwersytet Jagielloński, Wydział Chemii

Clinical efficacy of pharmacotherapy with antihistaminics and leukotriene antagonists and the therapy impact on cyclooxy...

Call: PRELUDIUM 1 , Panel: NZ5

Principal investigator: Paulina Korczyńska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Quantitative assessment of vascular endothelial growth factor (VEGF) in serum, follicular fluid (FF) and VEGF mRNA in gr...

Call: OPUS 1 , Panel: NZ5

Principal investigator: prof. Artur Jakimiuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Co-crystallization and co-amorphization of angiotensin II receptor blockers leading to more soluble compounds with a bif...

Call: PRELUDIUM 17 , Panel: ST5

Principal investigator: Marika Turek

Uniwersytet Humanistyczno-Przyrodniczy im. Jana Długosza w Częstochowie

The assessment of cysteinyl leukotriene receptor antagonist role in inhibition of atherosclerosis, proliferation and its...

Call: OPUS 17 , Panel: NZ5

Principal investigator: dr hab. Paweł Maga

Uniwersytet Jagielloński, Collegium Medicum

Neuroprotective properties of 5-HT6 receptor ligands in the group of 2-arylpyrrole derivatives – a new insight into neur...

Call: PRELUDIUM 17 , Panel: NZ7

Principal investigator: Marcin Drop

Uniwersytet Jagielloński, Collegium Medicum

Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Marcin Ratajewski

Instytut Biologii Medycznej Polskiej Akademii Nauk

Połączone działanie agonistów receptorów adenozynowych i antagonistów receptora P2Y12 zwiększa hamowanie funkcji płytek ...

Call: ETIUDA 7 , Panel: NZ3

Principal investigator: Nina Wolska

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

Prognostic value of platelet-derived microRNAs in patients with acute coronary syndrome treated with novel P2Y12 recepto...

Call: PRELUDIUM 16 , Panel: NZ7

Principal investigator: dr hab. Aleksandra Gąsecka-van der Pol

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Development of macrocyclic peptide antagonists of the PD-1/PD-L1 pathway. Charcterization of simultaneous administration...

Call: SONATA 14 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

Social interaction between Bacillus subtilis and Dickeya solani

Call: OPUS 15 , Panel: NZ9

Principal investigator: prof. Michał Obuchowski

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Non-vitamin K antagonist oral anticoagulants (NOACs) as modulators of valvular calcification and inflammation in aortic ...

Call: OPUS 15 , Panel: NZ5

Principal investigator: dr hab. Joanna Natorska

Krakowski Szpital Specjalistyczny im. św. Jana Pawła II

Multifunctional ligands - TRPA1 channel antagonists and phosphodiesterases inhibitors as a new approach for the treatmen...

Call: OPUS 15 , Panel: NZ7

Principal investigator: dr hab. Grażyna Chłoń-Rzepa

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

New vanilloid type 1 receptor (TRPV1) antagonists in the search for substances with wide-spectrum of anticonvulsant and ...

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Krzysztof Kamiński

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Radiopharmaceuticals based on neurokinin-1 receptor antagonists for the diagnosis and therapy of a brain tumour - gliobl...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Aleksandra Misicka-Kęsik

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

New mulitple target-directed ligands - A1/A2A adenosine receptors antagonists and monoamine oxidase B inhibitors - searc...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Michał Załuski

Uniwersytet Jagielloński, Collegium Medicum, Wydział Farmaceutyczny

Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Katarzyna Szczepańska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr hab. Anna Więckowska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Old drugs - new perspectives: modulation of antibiotics activity by caffeine and pentoxifylline

Call: SONATA 11 , Panel: NZ7

Principal investigator: dr Anna Woziwodzka

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Molecular receptors as a tool for studies of interactions agonist/antagonist of H1 - H4 receptors

Call: PRELUDIUM 11 , Panel: ST5

Principal investigator: Małgorzata Walczak

Politechnika Łódzka, Wydział Chemiczny

Characterization and improvement of anti-cancer properties of second generation antagonists of Mdm2 oncoprotein

Call: SONATA 11 , Panel: NZ7

Principal investigator: dr Łukasz Skalniak

Uniwersytet Jagielloński, Wydział Chemii

5-HT6 receptor ligands as addition to antipsychotic therapy in schizophrenia - an impact on body weight, metabolic param...

Call: OPUS 10 , Panel: NZ7

Principal investigator: prof. Anna Wesołowska

Uniwersytet Jagielloński Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Maria Bretner

Politechnika Warszawska, Wydział Chemiczny

Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the lig...

Call: SONATA 1 , Panel: NZ2

Principal investigator: dr Michał Koliński

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN