Projects funded by the NCN


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49 projects found matching your search criteria :

  1. Estrogen receptor GPER as a modulator of inflammatory and functional gastrointestinal diseases and colorectal cancer

    Call: PRELUDIUM 9 , Panel: NZ5

    Principal investigator: Damian Jacenik

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  2. Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the lig...

    Call: SONATA 1 , Panel: NZ2

    Principal investigator: dr Michał Koliński

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  3. Non-quinazoline antagonists of apha1 and 5-HT2A receptors with pleiotropic effects as a new perspective for hypertension...

    Call: SONATA 8 , Panel: NZ7

    Principal investigator: dr Monika Kubacka

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  4. New selective antagonists of ionotropic glutamate non-NMDA receptors

    Call: OPUS 8 , Panel: NZ7

    Principal investigator: dr Ewa Szymańska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  5. Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: dr Agnieszka Łupicka-Słowik

    Politechnika Wrocławska, Wydział Chemiczny

  6. Influence of antagonists (scopolamine and 3-quinuclidinyl benzilate) and agosists (carbachol) of muscarinic cholinergic ...

    Call: PRELUDIUM 5 , Panel: NZ9

    Principal investigator: Szymon Chowański

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  7. The effect of cytoplasmic incompatibility inducing Wolbachia on the detection of intralocus sexual conflict

    Call: PRELUDIUM 5 , Panel: NZ8

    Principal investigator: Eoin Duffy

    Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

  8. Interactions between isolates of Potato virus Y (PVY) in mixed infections and their effects on the spatial distribution ...

    Call: OPUS 5 , Panel: NZ9

    Principal investigator: dr hab. Jerzy Syller

    Instytut Hodowli i Aklimatyzacji Roślin - Państwowy Instytut Badawczy

  9. Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric ...

    Call: SONATA 4 , Panel: NZ1

    Principal investigator: dr Dorota Latek

    Uniwersytet Warszawski, Wydział Chemii

  10. Studies on synergistic effects of selected phenols and polyphenols during peroxidation of model lipid systems.

    Call: PRELUDIUM 3 , Panel: ST4

    Principal investigator: Ewelina van Wenum

    Uniwersytet Warszawski, Wydział Chemii

  11. Synthesis and marking the activity of new potential antagonists of receptors for excitatory amino acids which have the s...

    Call: OPUS 1 , Panel: NZ4

    Principal investigator: prof. Aleksander Mazurek

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

  12. LCAP biomimetics - alicyclic amine derivatives as a new class of monoaminergic receptor ligands

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr hab. Paweł Zajdel

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  13. Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

    Call: PRELUDIUM 2 , Panel: ST5

    Principal investigator: Jolanta Dyniewicz

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  14. Conjugated linoleic acid (CLA)-induced transcriptional activation of PPAR-an investigation of molecular machanisms of pu...

    Call: OPUS 2 , Panel: NZ9

    Principal investigator: prof. Teresa Leszczyńska

    Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Technologii Żywności

  15. Analysis of the anti-nociceptive and anti-inflammatory action of histamine H4 receptor antagonist in inflammatory nocice...

    Call: PRELUDIUM 2 , Panel: NZ4

    Principal investigator: Przemysław Rzodkiewicz

    Instytut Reumatologii im. prof. dr hab. med. Eleonory Reicher

  16. Brain regions that mediate antipsychotic-induced changes in oscillatory activity recorded in the nucleus accumbens

    Call: OPUS 2 , Panel: NZ4

    Principal investigator: dr Mark Hunt

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  17. Targeting the serotonin 5-HT7 receptor in a search for new strategies of mental disorders treatment

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Patryk Pyka

    Uniwersytet Jagielloński, Collegium Medicum

  18. The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Katarzyna Szczepańska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  19. The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Magdalena Białoń

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  20. Dual 5-HT3 receptor/5-HT6 receptor antagonists in neuropsychiatric and neurological disorders

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: prof. Paweł Zajdel

    Uniwersytet Jagielloński, Collegium Medicum

  21. Opioid receptors in the basal ganglia of the brain as targets for alcohol abuse therapy.

    Call: OPUS 2 , Panel: NZ4

    Principal investigator: dr Jan Rodriguez Parkitna

    Instytut Farmakologii PAN

  22. The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Magdalena Żarnik

    Uniwersytet Jagielloński, Wydział Chemii

  23. Self-learning systems in the design of compounds modulating GPCR receptors activation.

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr hab. Dorota Latek

    Uniwersytet Warszawski, Wydział Chemii

  24. Quinoxalino-2,3-diones as potent tools for exploration of ionotropic kainate receptors

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: dr hab. Ewa Szymańska

    Uniwersytet Jagielloński, Collegium Medicum

  25. Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Andrzej Pilc

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  26. Evaluation of the activity of MDM2-p53 antagonist RG7388 in mouse cancer models, alone and in combination with anti-PD-1...

    Call: PRELUDIUM 18 , Panel: NZ5

    Principal investigator: Aneta Wiśniewska

    Uniwersytet Jagielloński, Wydział Chemii

  27. Histamine H3/H4 receptors as the attractive target for the search of biologically active substances

    Call: MAESTRO 1 , Panel: NZ4

    Principal investigator: prof. Katarzyna Kieć-Kononowicz

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  28. Co-crystallization and co-amorphization of angiotensin II receptor blockers leading to more soluble compounds with a bif...

    Call: PRELUDIUM 17 , Panel: ST5

    Principal investigator: Marika Turek

    Uniwersytet Humanistyczno-Przyrodniczy im. Jana Długosza w Częstochowie

  29. Clinical efficacy of pharmacotherapy with antihistaminics and leukotriene antagonists and the therapy impact on cyclooxy...

    Call: PRELUDIUM 1 , Panel: NZ5

    Principal investigator: Paulina Korczyńska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  30. The assessment of cysteinyl leukotriene receptor antagonist role in inhibition of atherosclerosis, proliferation and its...

    Call: OPUS 17 , Panel: NZ5

    Principal investigator: dr hab. Paweł Maga

    Uniwersytet Jagielloński, Collegium Medicum

  31. Neuroprotective properties of 5-HT6 receptor ligands in the group of 2-arylpyrrole derivatives – a new insight into neur...

    Call: PRELUDIUM 17 , Panel: NZ7

    Principal investigator: Marcin Drop

    Uniwersytet Jagielloński, Collegium Medicum

  32. Quantitative assessment of vascular endothelial growth factor (VEGF) in serum, follicular fluid (FF) and VEGF mRNA in gr...

    Call: OPUS 1 , Panel: NZ5

    Principal investigator: prof. Artur Jakimiuk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  33. Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR...

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: dr hab. Marcin Ratajewski

    Instytut Biologii Medycznej Polskiej Akademii Nauk

  34. Połączone działanie agonistów receptorów adenozynowych i antagonistów receptora P2Y12 zwiększa hamowanie funkcji płytek ...

    Call: ETIUDA 7 , Panel: NZ3

    Principal investigator: Nina Wolska

    Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

  35. Prognostic value of platelet-derived microRNAs in patients with acute coronary syndrome treated with novel P2Y12 recepto...

    Call: PRELUDIUM 16 , Panel: NZ7

    Principal investigator: dr hab. Aleksandra Gąsecka-van der Pol

    Warszawski Uniwersytet Medyczny, I Wydział Lekarski

  36. Development of macrocyclic peptide antagonists of the PD-1/PD-L1 pathway. Charcterization of simultaneous administration...

    Call: SONATA 14 , Panel: NZ7

    Principal investigator: dr Katarzyna Magiera-Mularz

    Uniwersytet Jagielloński, Wydział Chemii

  37. Social interaction between Bacillus subtilis and Dickeya solani

    Call: OPUS 15 , Panel: NZ9

    Principal investigator: prof. Michał Obuchowski

    Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  38. Non-vitamin K antagonist oral anticoagulants (NOACs) as modulators of valvular calcification and inflammation in aortic ...

    Call: OPUS 15 , Panel: NZ5

    Principal investigator: dr hab. Joanna Natorska

    Krakowski Szpital Specjalistyczny im. św. Jana Pawła II

  39. Multifunctional ligands - TRPA1 channel antagonists and phosphodiesterases inhibitors as a new approach for the treatmen...

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: dr hab. Grażyna Chłoń-Rzepa

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  40. New vanilloid type 1 receptor (TRPV1) antagonists in the search for substances with wide-spectrum of anticonvulsant and ...

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr hab. Krzysztof Kamiński

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  41. Radiopharmaceuticals based on neurokinin-1 receptor antagonists for the diagnosis and therapy of a brain tumour - gliobl...

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Aleksandra Misicka-Kęsik

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  42. New mulitple target-directed ligands - A1/A2A adenosine receptors antagonists and monoamine oxidase B inhibitors - searc...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Michał Załuski

    Uniwersytet Jagielloński, Collegium Medicum, Wydział Farmaceutyczny

  43. Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Katarzyna Szczepańska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  44. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Anna Więckowska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  45. Old drugs - new perspectives: modulation of antibiotics activity by caffeine and pentoxifylline

    Call: SONATA 11 , Panel: NZ7

    Principal investigator: dr Anna Woziwodzka

    Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  46. Molecular receptors as a tool for studies of interactions agonist/antagonist of H1 - H4 receptors

    Call: PRELUDIUM 11 , Panel: ST5

    Principal investigator: Małgorzata Walczak

    Politechnika Łódzka, Wydział Chemiczny

  47. Characterization and improvement of anti-cancer properties of second generation antagonists of Mdm2 oncoprotein

    Call: SONATA 11 , Panel: NZ7

    Principal investigator: dr Łukasz Skalniak

    Uniwersytet Jagielloński, Wydział Chemii

  48. 5-HT6 receptor ligands as addition to antipsychotic therapy in schizophrenia - an impact on body weight, metabolic param...

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: prof. Anna Wesołowska

    Uniwersytet Jagielloński Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  49. Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

    Call: OPUS 9 , Panel: ST5

    Principal investigator: prof. Maria Bretner

    Politechnika Warszawska, Wydział Chemiczny