Projects funded by the NCN

Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the lig...

Call: SONATA 1 , Panel: NZ2

Principal investigator: dr Michał Koliński

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Molecular mechanism of unique action of clozapine in the context of GPCR.

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr Agata Faron-Górecka

Instytut Farmakologii PAN

Halogen bonding - the role and significance in interactions of ligands with class A GPCRs

Call: SONATA 8 , Panel: NZ7

Principal investigator: dr Rafał Kurczab

Instytut Farmakologii PAN

GPR18 orphan receptor. Search for the tools to investigate GPR18 as potential therapeutic target

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Katarzyna Kieć-Kononowicz

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

The mechanism of ligand binding and the conformational changes in the beta2-adrenergic receptor molecule

Call: SONATA 5 , Panel: NZ2

Principal investigator: dr Anita Płazińska

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Study of interaction and signal passing in complexes of GPCRs with arrestin

Call: HARMONIA 4 , Panel: ST6

Principal investigator: prof. Sławomir Filipek

Uniwersytet Warszawski, Wydział Chemii

Study of ligand binding and activation processes of formyl, opioid and cannabinoid G-protein-coupled receptors

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Sławomir Filipek

Uniwersytet Warszawski, Wydział Chemii

Prognostic potential of neuromedin U and its receptors in the colorectal cancer, importance in the metastasis.

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr Patrycja Przygodzka

Instytut Biologii Medycznej Polskiej Akademii Nauk

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Expression and function of Regulator of G Protein Signaling (RGS) proteins in physiological and pathophysiological condi...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr hab. Maciej Sałaga

Uniwersytet Medyczny w Łodzi

Seeking for CB1 and CB2 receptor ligands among drugs, drug metabolites, and phytochemical compounds

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Adam Stasiulewicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Diet and human gut microbiome as sources of N-acyl amines acting as GPCR ligands.

Call: SONATINA 2 , Panel: NZ9

Principal investigator: dr Anna Drzazga

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

MOLECULAR DETERMINANTS OF SIGNAL PROPAGATION IN THE DELTA AND MU OPIOID RECEPTORS - IN SEARCH FOR ANALGETICS WITH LESS S...

Call: PRELUDIUM 14 , Panel: NZ2

Principal investigator: Tomasz Stepniewski

Uniwersytet Warszawski, Wydział Chemii

Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Multiscale investigations on polymorphism of the beta2-adrenergic receptor: from molecular-scale processes to heart fail...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Anita Płazińska

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Novel ligands of histamine receptor H4 as potential anti-allergic and anti-inflammatory drugs

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Sławomir Filipek

Uniwersytet Warszawski, Wydział Chemii

Molecular modeling of allosteric binding and allosteric-orthosteric coupling in cannabinoid receptor CB1

Call: PRELUDIUM 12 , Panel: NZ1

Principal investigator: Jakub Jakowiecki

Uniwersytet Warszawski, Wydział Chemii

Molecular mechanism of interactions between GPCRs and G protein.

Call: PRELUDIUM 10 , Panel: NZ2

Principal investigator: Stefan Mordalski

Instytut Farmakologii Polskiej Akademii Nauk

A virtual screening protocol based on automatically generated structure-based pharmacophore models.

Call: HARMONIA 7 , Panel: NZ2

Principal investigator: Stefan Mordalski

Instytut Farmakologii PAN