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The role of DNA methylation in etiology of high myopia in Polish children

2019/35/N/NZ5/03150

Keywords:

high myopia DNA methylation epigenetics eye disease etiology eye disease pathogenesis refractive error candidate genes

Descriptors:

  • NZ5_001:
  • NZ2_001:
  • NZ2_002:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Genetyki Człowieka Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Świerkowska-Janc 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2020-06-22

Project end date (Y-m-d): 2025-06-21

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (5)
  1. Differential methylation of microRNA encoding genes may contribute to high myopia
    Authors:
    Joanna Swierkowska, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Academic press:
    Frontiers in Genetics (rok: 2023, tom: 13, strony: 45666), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fgene.2022.1089784 - link to the publication
  2. Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Academic press:
    Investigative Ophthalmology & Visual Science (rok: 2022, tom: 63, strony: 45667), Wydawca: The Association for Research in Vision and Ophthalmology (ARVO)
    Status:
    Published
    DOI:
    10.1167/iovs.63.9.31 - link to the publication
  1. Processing eye samples from patients with high myopia towards DNA methylation and gene expression analyses
    Authors:
    Joanna Swierkowska, Anna Mikolajczyk-Lorkiewicz, Marcin Stopa, Małgorzata Mrugacz, Marzena Gajecka
    Conference:
    Abstracts from the 57th European Society of Human Genetics (ESHG) Conference: Hybrid Posters (rok: 2024, tom: European Human Genetics Conference (ESHG 2024), strony: 1344-1345), Wydawca: European Journal of Human Genetics, Springer Nature
    Data:
    konferencja 1-4.06.2024
    Status:
    Published
    DOI:
    10.1038/s41431-024-01734-4 - link to the publication
  2. Differential methylation of microRNAs encoding genes may contribute to high myopia
    Authors:
    Joanna Swierkowska, Sangeetha Vishweswaraiah, Justyna A. Karolak, Małgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Status:
    Accepted for publication
  3. The role of the PCDHA10 gene in high myopia pathogenesis – further investigation
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Status:
    Accepted for publication
  4. Is the decreased methylation of the PCDHA10 gene causative in high myopia in children?
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Status:
    Accepted for publication
  5. The role of the PCDHA10 gene in high myopia pathogenesis – further investigation
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Status:
    Accepted for publication

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