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The role of DNA methylation in etiology of high myopia in Polish children

2019/35/N/NZ5/03150

Keywords:

high myopia DNA methylation epigenetics eye disease etiology eye disease pathogenesis refractive error candidate genes

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Genetyki Człowieka Polskiej Akademii Nauk

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Świerkowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2020-06-22

Project end date (Y-m-d): 2024-06-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (7)
  1. Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Academic press:
    Investigative Ophthalmology & Visual Science (rok: 2022, tom: 63, strony: 45667), Wydawca: The Association for Research in Vision and Ophthalmology (ARVO)
    Status:
    Published
    DOI:
    10.1167/iovs.63.9.31 - link to the publication
  2. Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Academic press:
    Investigative Ophthalmology & Visual Science (rok: 2022, tom: 63, strony: 45667), Wydawca: The Association for Research in Vision and Ophthalmology (ARVO)
    Status:
    Published
    DOI:
    10.1167/iovs.63.9.31 - link to the publication
  3. Differential methylation of microRNA encoding genes may contribute to high myopia
    Authors:
    Joanna Swierkowska, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Academic press:
    Frontiers in Genetics (rok: 2023, tom: 13, strony: 45666), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fgene.2022.1089784 - link to the publication
  4. Differential methylation of microRNA encoding genes may contribute to high myopia
    Authors:
    Joanna Swierkowska, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Academic press:
    Frontiers in Genetics (rok: 2023, tom: 13, strony: 45666), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fgene.2022.1089784 - link to the publication
  1. Is the decreased methylation of the PCDHA10 gene causative in high myopia in children?
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Abstracts from the 55th European Society of Human Genetics (ESHG) Conference (rok: 2023, tom: European Human Genetics Conference 2022, strony: Nie dotyczy), Wydawca: European Journal of Human Genetics, Springer Nature
    Data:
    konferencja 11-14.06.2022
    Status:
    Accepted for publication
  2. The role of the PCDHA10 gene in high myopia pathogenesis – further investigation
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Abstracts from the International Myopia Conference (rok: 2023, tom: International Myopia Conference, strony: Nie dotyczy), Wydawca: Nie dotyczy
    Data:
    konferencja 3-7.09.2022
    Status:
    Accepted for publication
  3. The role of the PCDHA10 gene in high myopia pathogenesis – further investigation
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Abstracts from the International Myopia Conference (rok: 2023, tom: International Myopia Conference, strony: Nie dotyczy), Wydawca: Nie dotyczy
    Data:
    konferencja 3-7.09.2022
    Status:
    Accepted for publication
  4. Differential methylation of microRNAs encoding genes may contribute to high myopia
    Authors:
    Joanna Swierkowska, Sangeetha Vishweswaraiah, Justyna A. Karolak, Małgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Abstracts from the European Society of Human Genetics (ESHG) Conference: Posters (tom: European Human Genetics Confer, strony: ), Wydawca: EUROPEAN JOURNAL OF HUMAN GENETICS
    Data:
    konferencja 28 – 31.08.2021
    Status:
    Accepted for publication
  5. Differential methylation of microRNAs encoding genes may contribute to high myopia
    Authors:
    Joanna Swierkowska, Sangeetha Vishweswaraiah, Justyna A. Karolak, Małgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Abstracts from the European Society of Human Genetics (ESHG) Conference: Posters (tom: European Human Genetics Confer, strony: ), Wydawca: EUROPEAN JOURNAL OF HUMAN GENETICS
    Data:
    konferencja 28 – 31.08.2021
    Status:
    Accepted for publication
  6. Differential methylation of microRNAs encoding genes may contribute to high myopia
    Authors:
    Joanna Swierkowska, Sangeetha Vishweswaraiah, Justyna A. Karolak, Małgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Abstracts from the European Society of Human Genetics (ESHG) Conference: Posters (tom: European Human Genetics Confer, strony: ), Wydawca: EUROPEAN JOURNAL OF HUMAN GENETICS
    Data:
    konferencja 28 – 31.08.2021
    Status:
    Accepted for publication
  7. Is the decreased methylation of the PCDHA10 gene causative in high myopia in children?
    Authors:
    Joanna Swierkowska, Justyna A. Karolak, Sangeetha Vishweswaraiah, Malgorzata Mrugacz, Uppala Radhakrishna, Marzena Gajecka
    Conference:
    Abstracts from the 55th European Society of Human Genetics (ESHG) Conference (rok: 2023, tom: European Human Genetics Conference 2022, strony: Nie dotyczy), Wydawca: European Journal of Human Genetics, Springer Nature
    Data:
    konferencja 11-14.06.2022
    Status:
    Accepted for publication

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