Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Elucidating the function of the transmembrane protein TMEM244 and its role in the development of lymphoid malignancies

2017/27/B/NZ5/01540

Keywords:

TMEM244 Sezary syndrome CTCL lymphoma

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Genetyki Człowieka Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Przybylski 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 834 600 PLN

Project start date (Y-m-d): 2018-06-29

Project end date (Y-m-d): 2021-12-28

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Taca do systemu ChemiDoc MP.
  2. Urządzenie do przygotowywania indywidualnych bibliotek cDNA z populacji komórek (436 000 PLN)
  3. Urządzenie do wizualizacji blotów w oparciu o chemiluminescencję.
  4. Zamrażarka niskotemperaturowa.
  5. Wirówka.

Information in the final report

  • Publication in academic press/journals (3)
  1. Single-Cell Heterogeneity of Cutaneous T-Cell Lymphomas Revealed Using RNA-Seq Technologies
    Authors:
    Rassek K., Iżykowska K.
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12082129 - link to the publication
  2. Methylation patterns of cutaneous T-cell lymphomas
    Authors:
    Iżykowska K.
    Academic press:
    Experimental Dermatology (rok: 2021, tom: 30, strony: 1135-1140), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/exd.14108 - link to the publication
  3. Hypomethylation of the promoter region drives ectopic expression of TMEM244 in Sézary cells
    Authors:
    Iżykowska K., Rassek K., Żurawek M., Nowicka K., Paczkowska J., Ziółkowska-Suchanek I., Podralska M., Dzikiewicz-Krawczyk A., Joks M., Olek-Hrab K., Giefing M., Przybylski GK.
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2020, tom: 24, strony: 10970-10977), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jcmm.15729 - link to the publication

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