Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Synergistic effect of alternating magnetic field and light conversion within Ist and IInd biological optical window on nanostructural ferrites for modern thermal therapies of neoplastic diseases

2017/25/B/ST5/00497

Keywords:

synergy hyperthermia nanomaterials ferrites energy conversion magnetic field cancer

Descriptors:

  • ST5_1: Structural properties of materials
  • ST5_12: Methods of nanomaterials/materials synthesis
  • NZ3_3: Apoptosis

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Robert Pązik 

Number of co-investigators in the project: 6

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 873 116 PLN

Project start date (Y-m-d): 2018-01-10

Project end date (Y-m-d): 2023-01-09

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikrowaga (36 000 PLN)
  2. Oprogramowanie specjalistyczne Affinity Photo.
  3. Źródło promieniowania elektromagnetycznego z zakresu I bramki biologicznej laser 808 nm 2700 mW z regulacją mocy (18 000 PLN)
  4. Kamera termowizyjna z akcesoriami (177 000 PLN)
  5. Komputer klasy Laptop (14 000 PLN)
  6. Miernik mocy do kalibracji i walidacji źródeł promieniowania.
  7. Urządzenia wielofunkcyjne z niszczarką.
  8. Czasza grzewcza wraz z czujnikiem tempertury.
  9. Mieszadło mechaniczne.
  10. Płyta grzewacza z mieszadlem magneycznym i czujnikiem temperatury.
  11. Źródło promieniowania elektromagnetycznego z zakresu II bramki biologicznej laser 1122 nm 900 mW z regulacją mocy (45 000 PLN)
  12. Akrylowa komora rękawicowa z akcesoriami (67 000 PLN)
  13. Oprogramowanie do archiwiacji danych i obróbki wyników projektu.
  14. Oprogramowanie Origin Pro (12 000 PLN)
  15. Urządzenie do badania hypertermii z wykorzystaniem stymualcji zmiennym polem magnetycznym i promienowaniem podczerwonym (380 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  1. Synergic Temperature Effect of Star-like Monodisperse Iron Oxide Nanoparticles and Their Related Responses in Normal and Cancer Cells
    Authors:
    M. Kulpa-Greszta, M. Wnuk, A. Tomaszewska, J. Adamczyk-Grochala, A. Dziedzic, I. Rzeszutek, B. Zarychta, D. Błoniarz, A. Lewińska, R. Pązik
    Academic press:
    Journal of Physical Chemistry B (rok: 2022, tom: 126, strony: 8515-8531), Wydawca: American Chemical Society ACS
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.2c06061 - link to the publication
  2. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts
    Authors:
    A. Lewinska, J, Adamczyk-Grochala, D. Bloniarz, J. Olszowka, M. Kulpa-Greszta, G. Litwinienko, A. Tomaszewska, M. Wnuk, R. Pazik
    Academic press:
    Redox Biology (rok: 2020, tom: 28, strony: 101337), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2019.101337 - link to the publication
  3. Multifunctional properties of binary polyrhodanine manganese ferrite nanohybrids—from the energy converters to biological activity
    Authors:
    E. Zachanowicz, M. Kulpa-Greszta, A. Tomaszewska, M. Gazińska, M. Marędziak, K. Marycz, R. Pązik
    Academic press:
    Polymers (rok: 2020, tom: 12, strony: 2934), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym12122934 - link to the publication
  4. Energy Conversion and Biocompatibility of Surface Functionalized Magnetite Nanoparticles with Phosphonic Moieties
    Authors:
    R. Pązik, A. Lewińska, J. Adamczyk-Grochala, M. Kulpa-Greszta, P. Kłoda, A. Tomaszewska, A. Dziedzic, G. Litwinienko, M. Noga, D. Sikora, M. Wnuk
    Academic press:
    Journal of Physical Chemistry B (rok: 2020, tom: 124, strony: 4931-4948), Wydawca: American Chemical Society ACS
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.0c02808 - link to the publication
  5. Heat generation on Fe3O4@SiO2@Au core-shell structures using the synergy of an alternating magnetic field and NIR laser light within Ist biological optical window
    Authors:
    M. Kulpa-Greszta, A. Tomaszewska, A. Dziedzic, I. Rzeszutek, R. Pązik
    Academic press:
    Materials Today Communications (rok: 2023, tom: 35, strony: 105513), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mtcomm.2023.105513 - link to the publication
  6. Alternating magnetic field and NIR energy conversion on magneto-plasmonic Fe3O4@APTES-Ag heterostructures with SERS detection capability and antimicrobial activity
    Authors:
    M. Kulpa-Greszta, A. Tomaszewska, A. Michalicha, D. Sikora, A. Dziedzic, R. Wojnarowska-Nowak, A. Belcarz, R. Pązik
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 27396 - 27410), Wydawca: Royal Society of Chemistry RSC
    Status:
    Published
    DOI:
    10.1039/d2ra05207e - link to the publication
  7. Efficient non-contact heat generation on flexible, ternary hydroxyapatite/curdlan/nanomagnetite hybrids for temperature controlled processes
    Authors:
    M. Kulpa-Greszta, R. Pązik, P. Kłoda, A. Tomaszewska, E. Zachanowicz, K. Pałka, G. Ginalska, A. Belcarz
    Academic press:
    Materials Science and Engineering C (rok: 2021, tom: 118, strony: 111360), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2020.111360 - link to the publication
  8. Rapid hot-injection as a tool for control of magnetic nanoparticle size and morphology
    Authors:
    M. Kulpa-Greszta, A. Tomaszewska, A. Dziedzic, R. Pązik
    Academic press:
    RSC Advances (rok: 2021, tom: 11, strony: 20708-20719), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1RA02977K - link to the publication
  9. Contactless and synergic heat generation using AMF and laser radiation within 1st and 2nd optical biological window on PMMA covered cobalt-manganese ferrite hybrid particles
    Authors:
    M. Kulpa-Greszta, A. Tomaszewska, E. Zachanowicz, P. Krzemiński, R. Pązik
    Academic press:
    Journal of Alloys and Compounds (rok: 2022, tom: 898, strony: 162840), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jallcom.2021.162840 - link to the publication
  10. Efficient NIR energy conversion of plasmonic silver nanostructures fabricated with the laser-assisted synthetic approach for endodontic applications
    Authors:
    T. Bulavinets, M. Kulpa-Greszta, A. Tomaszewska, M. Kus-Liśkiewicz, G. Bielatowicz, I. Yaremchuk, A. Barylyak, Y. Bobitski, R. Pązik
    Academic press:
    RSC Advances (rok: 2020, tom: 10, strony: 38861-38872), Wydawca: Royal Society of Chemistry RSC
    Status:
    Published
    DOI:
    10.1039/D0RA06614A - link to the publication
  11. Multimodal polymer encapsulated CdSe/Fe3O4 nanoplatform with improved biocompatibility for two-photon and temperature stimulated bioapplications
    Authors:
    M.A. Antoniak, R. Pązik, U. Bazylińska, K. Wiwatowski, A. Tomaszewska, M. Kulpa-Greszta, J. Adamczyk-Grochala, M. Wnuk, S. Maćkowski, A. Lewińska, M. Nyk
    Academic press:
    Materials Science and Engineering C (rok: 2021, tom: 127, strony: 112224), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2021.112224 - link to the publication
  12. Temperature effects induced by NIR photo-stimulation within Ist and IInd optical biological window of seed-mediated multi-shell nanoferrites
    Authors:
    M. Kulpa-Greszta, A. Tomaszewska, A. Dziedzic, R. Pązik
    Academic press:
    Dalton Transactions (rok: 2023, tom: 52, strony: 2580), Wydawca: Royal Society of Chemistry RSC
    Status:
    Published
    DOI:
    10.1039/D2DT04178B - link to the publication