Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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CRISPR/Cas9 screen for identification of functional MYC binding sites and target genes essential for cancer cell growth

2016/23/D/NZ1/01611

Keywords:

MYC MYC target genes cancer CRISPR/Cas9 high-throughput screen

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ3_1: Cell biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Genetyki Człowieka Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Dzikiewicz-Krawczyk 

Number of co-investigators in the project: 6

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 815 000 PLN

Project start date (Y-m-d): 2017-08-04

Project end date (Y-m-d): 2021-08-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator CO2 Binder C170 (35 000 PLN)
  2. Mikroskop odwrócony Leica DMIL LED z modułem fluorescencyjnym GFP (65 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Intricate crosstalk between MYC and non-coding RNAs regulates hallmarks of cancer
    Authors:
    Swier LJYM, Dzikiewicz-Krawczyk A, Winkle M, van den Berg A, Kluiver J
    Academic press:
    Molecular Oncology (rok: 2018, tom: Epub Dec5, strony: -), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1002/1878-0261.12409 - link to the publication
  2. The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cells
    Authors:
    Winkle M, Tayari MM, Kok K, Duns G, Grot N, Kazimierska M, Seitz A, de Jong D, Koerts J, Diepstra A, Dzikiewicz-Krawczyk A, Steidl C, Kluiver J, van den Berg A
    Academic press:
    Human Molecular Genetics (rok: 2022, tom: 31(24), strony: 4193-4206), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/hmg/ddac159 - link to the publication
  3. TransCRISPR-sgRNA design tool for CRISPR/Cas9 experiments targeting specific sequence motifs
    Authors:
    Woźniak T, Sura W, Kazimierska M, Kasprzyk ME, Podralska M, Dzikiewicz-Krawczyk A
    Academic press:
    Nucleic Acids Research (rok: 2023, tom: -, strony: 45301), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkad355 - link to the publication
  4. CRISPR/Cas9 screen for genome-wide interrogation of essential MYC-bound E-boxes in cancer cells
    Authors:
    Marta Kazimierska, Marta Podralska, Magdalena Żurawek, Tomasz Woźniak, Marta Elżbieta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Iwona Ziółkowska-Suchanek, Joost Kluiver, Anke van den Berg, Natalia Rozwadowska, Agnieszka Dzikiewicz-Krawczyk
    Academic press:
    Molecular Oncology (rok: 2023, tom: -, strony: -), Wydawca: FEBS Press
    Status:
    Accepted for publication
    DOI:
    10.1101/2021.08.02.454734v3 - link to the publication
  5. The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth
    Authors:
    Fubiao Niu, Marta Kazimierska, Ilja M Nolte, Miente Martijn Terpstra, Debora de Jong, Jasper Koerts, Tineke van der Sluis, Bea Rutgers, Ryan M O'Connell, Klaas Kok, Anke van den Berg, Agnieszka Dzikiewicz-Krawczyk, Joost Kluiver
    Academic press:
    Cancers (rok: 2020, tom: 12(6), strony: 1464), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12061464 - link to the publication
  1. NGS-based high-throughput screen to identify microRNAs regulating growth of B-cell lymphoma
    Authors:
    Kluiver J, Niu F, Yuan Y, Kok K, van den Berg A, Dzikiewicz-Krawczyk A
    Book:
    Methods in Molecular Biology. Lymphoma (rok: 2019, tom: 1956, strony: 269-282), Wydawca: SpringerLink
    Status:
    Published

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