Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Influence of (5'R) and (5'S) 5',8-cyclo-2'-deoxypurines on clustered DNA lesions repair

2016/23/B/NZ7/03367

Keywords:

5',8-cyclo-2'-deoxypurines clustered DNA damage DNA repair mechanisms ionisation radiation reactive oxygen species mutation

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases
  • NZ7_4: Prevention in population health

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Bolesław Karwowski 

Number of co-investigators in the project: 3

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 867 682 PLN

Project start date (Y-m-d): 2017-08-10

Project end date (Y-m-d): 2022-08-09

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wysoko Sprawny Chromatograf Cieczowy z Detektorem PDA (143 910 PLN)
  2. Elektroniczny system dokumentacji żeli: Syngen Imagine (36 039 PLN)
  3. System do elektroporacji komórkowej: ECM 630 ElectroSquarePorator (50 733 PLN)

Information in the final report

  • Publication in academic press/journals (22)
  1. Nutrition Can Help DNA Repair in the Case of Aging
    Authors:
    Julia Kaźmierczak-Barańska, Karolina Boguszewska, Bolesław T. Karwowski
    Academic press:
    Nutrients (rok: 2020, tom: 12(11), strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu12113364 - link to the publication
  2. The Clustered DNA Lesions – Types, Pathways of Repair and Relevance to Human Health
    Authors:
    Barbara Bukowska Bolesław T. Karwowski
    Academic press:
    Current Medicinal Chemistry (rok: 2018, tom: 25, strony: 2722-2735), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/0929867325666180226110502 - link to the publication
  3. 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development
    Authors:
    Sandra Urbaniak, Karolina Boguszewska, Michał Szewczuk, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
    Academic press:
    Molecules (rok: 2020, tom: 25(1), strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25010202 - link to the publication
  4. Clustered DNA Damage: Electronic Properties and Their Influence on Charge Transfer. 7,8-Dihydro-8-Oxo-2′-Deoxyguaosine Versus 5′,8-Cyclo-2′-Deoxyadenosines: A Theoretical Approach
    Authors:
    Bolesław T. Karwowski
    Academic press:
    Cells (rok: 2020, tom: 9(2), strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9020424 - link to the publication
  5. How (5'S) and (5'R) 5'8-Cyclo-2'-Deoxypurines Affect Base Excision Repair of Clustered DNA Damage in Nuclear Extracts of xrs5 Cells? A Biochemical Study
    Authors:
    Karolina Boguszewska, Michał Szewczuk, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
    Academic press:
    Cells (rok: 2021, tom: 10 (4), strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10040725 - link to the publication
  6. Review: Immunoassays in DNA damage and instability detection
    Authors:
    Karolina Boguszewska, Michał Szewczuk, Sandra Urbaniak, Bolesław T.Karwowski
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2019, tom: 76, strony: 4689–4704), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-019-03239-6 - link to the publication
  7. The Influence of (5'R)- and (5'S), 8-Cyclo-2'-Deoxyadenosine on UDG and hAPE1 Activity. Tandem Lesions are the Base Excision Repair System's Nightmare
    Authors:
    Bolesław T. Karwowski
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8111303 - link to the publication
  8. The Influence of 5'R and 5'S cdA and cdG on the Activity of BsmAI and Sspl Restriction Enzymes
    Authors:
    Michał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
    Academic press:
    Molecules (rok: 2021, tom: 26(12), strony: 45302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26123750 - link to the publication
  9. The Influence of Single, Tandem, and Clustered DNA Damage on the Electronic Properties of the Double Helix: A Theoretical Study
    Authors:
    Bolesław T. Karwowski
    Academic press:
    Molecules (rok: 2020, tom: 25(14), strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25143126 - link to the publication
  10. The Usefulness of Autoradiography for DNA Repair Proteins Activity Detection in the Cytoplasm towards Radiolabeled Oligonucleotides Containing 5′,8-Cyclo-2′-deoxyadenosine
    Authors:
    Karolina Boguszewska, Bolesław T. Karwowski, Julia Kaźmierczak-Barańska
    Academic press:
    Chemosensors (rok: 2022, tom: 10, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/chemosensors10060204 - link to the publication
  11. The influence of cdG on 8-oxodG excision by OGG1 and FPG glycosylases
    Authors:
    Michał Szewczuk, Bolesław Karwowski
    Academic press:
    Acta Biochimica Polonica (rok: 2022, tom: 69, strony: 227-232), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2020_5966 - link to the publication
  12. The role of AMPK in metabolism and its influence on DNA damage repair
    Authors:
    Michał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
    Academic press:
    Molecular Biology Reports (rok: 2020, tom: 47, strony: 9075-9086), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11033-020-05900-x - link to the publication
  13. When UDG and hAPE1 Meet Cyclopurines. How (5'R) and (5'S) 5',8-Cyclo-2'-Deoxyadenosine and 5',8-Cyclo-2'-Deoxyguanosine Affect UDG and hAPE1 Activity?
    Authors:
    Michał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
    Academic press:
    Molecules (rok: 2021, tom: 26(17), strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26175177 - link to the publication
  14. (5'S) 5'8-Cyclo-2'-Deoxyadenosine Cannot Stop BER. Clustered DNA Lesion Studies
    Authors:
    Bolesław T. Karwowski
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22 (11), strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22115934 - link to the publication
  15. Actual state of knowledge in the field of diseases related with defective nucleotide excision repair
    Authors:
    Barbara Bukowska, Bolesław T. Karwowski
    Academic press:
    Life Sciences (rok: 2018, tom: 195, strony: 45461), Wydawca: ELSEWIER
    Status:
    Published
    DOI:
    10.1016/j.lfs.2017.12.035 - link to the publication
  16. The Electronic Property Differences between dA::dG and dA::dGoxo. A Theoretical Approach
    Authors:
    Bolesław T. Karwowski
    Academic press:
    Molecules (rok: 2020, tom: 25(17), strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25173828 - link to the publication
  17. The Influence of oxoG on the Electronic Properties of ds-DNA. Damage versus mismatch: A theoretical approach
    Authors:
    Bolesław T. Karwowski
    Academic press:
    Computational Biology and Chemistry (rok: 2021, tom: 92, strony: 45298), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.compbiolchem.2021.107485 - link to the publication
  18. The Similarities between Human and Bacteria in the context of Structure, Genome and Base Excision Repair System
    Authors:
    Karolina Boguszewska, Michał Szewczuk, Julia Kaźmierczak-Barańska,, Bolesław T. Karwowski
    Academic press:
    Molecules (rok: 2020, tom: 25(12), strony: 45321), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25122857 - link to the publication
  19. Mutagenicity of a bi-stranded clustered DNA lesion containing (5´S) or (5´R) 5´,8-cyclo-2´-deoxyAdenosine in Escherichia coli model
    Authors:
    Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski*
    Academic press:
    Acta Biochimica Polonica (rok: 2022, ), Wydawca: Polish Biochemical Society
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  20. The Influence of 5',8-Cyclo-2'-Deoxypurines on the Mitochondrial Repair of Clustered DNA Damage in Xrs5 Cells: The Preliminary Study
    Authors:
    Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski
    Academic press:
    Molecules (rok: 2021, tom: 26 (22), strony: 45303), Wydawca: MDPI
    Status:
    Accepted for publication
    DOI:
    10.3390/molecules26227042 - link to the publication
  21. 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) as a Cause of Autoimmune Thyroid Diseases (AITD) During Pregnancy?
    Authors:
    Krzysztof Halczuk, Karolina Boguszewska, Sandra Urbaniak, Michał Szewczuk, Bolesław T. Karwowski
    Academic press:
    Yale Journal of Biology and Medicine (rok: 2020, tom: 93(4), strony: 501-515), Wydawca: PubMed Central
    Status:
    Published
    DOI:
    brak - link to the publication
  22. Effects of 5',8-Cyclo-2'-Deoxypurines on the Base Excision Repair of Clustered DNA Lesions in Nuclear Extracts of XPC Cell Line
    Authors:
    Julia Kaźmierczak-Barańska, Karolina Boguszewska, Michał Szewczuk, Bolesław T. Karwowski
    Academic press:
    Cells (rok: 2021, tom: 10 (11), strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10113254 - link to the publication

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