Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Altered interaction between NMDA receptor subunits and their scaffolding proteins as a critical step to control drug seeking and relapse behavior following cocaine abstinence

2015/17/B/NZ7/02935

Keywords:

cocaine forced abstinence cocaine seeking and relapse yoked procedure rats Tat-NR2B9c peptide virus vectors molecular analyses (immunoprecipitation TIF TST BS3 crosslinking)

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ5_4: Pathogenesis of animal diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Filip 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 409 064 PLN

Project start date (Y-m-d): 2016-04-28

Project end date (Y-m-d): 2021-04-27

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Enhancement of the GluN2B subunit of glutamatergic NMDA receptors in rat brain areas after cocaine abstinence
    Authors:
    Irena Smaga, Karolina Wydra, Agata Suder, Marek Sanak, Lucia Caffino, Fabio Fumagalli, Malgorzata Filip
    Academic press:
    Journal of Psychopharmacology (rok: 2021, ), Wydawca: SAGE journals
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Cocaine Self-Administration and Abstinence Modulate NMDA Receptor Subunits and Active Zone Proteins in the Rat Nucleus Accumbens
    Authors:
    Smaga I., Wydra K., Frankowska M., Fumagalli F., Sanak M., Filip M.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25153480 - link to the publication
  3. Cocaine abstinence modulates NMDA receptor subunit expression: An analysis of the GluN2B subunit in cocaine-seeking behavior
    Authors:
    Irena Smaga, Karolina Wydra, Marcin Piechota, Lucia Caffino, Fabio Fumagalli, Marek Sanak, Małgorzata Filip
    Academic press:
    Progress in Neuropsychopharmacology and Biological Psychiatry (rok: 2021, tom: 109, strony: 110248), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2021.110248 - link to the publication
  4. Cocaine-induced changes in the expression of NMDA receptor subunits
    Authors:
    Smaga I., Sanak M., Filip M.
    Academic press:
    Current Neuropharmacol. (rok: 2019, tom: 17 (11), strony: 1039-1055), Wydawca: Betham Science
    Status:
    Published
    DOI:
    10.2174/1570159X17666190617101726 - link to the publication
  5. The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures
    Authors:
    Irena Smaga, Karolina Wydra,· Agata Suder, · Małgorzata Frankowska,· Marek Sanak,· Lucia Caffino, · Fabio Fumagalli, · Małgorzata Filip
    Academic press:
    Neurotoxicity Research (rok: 2021, tom: 39, strony: 556-565), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-021-00350-0 - link to the publication
  1. Changes in the brain expression of GluN1 subunit in different conditions of cocaine forced abstinence.
    Authors:
    Smaga I., Wydra K., Caffino L., Fumagalli F., Sanak M., Filip M.
    Conference:
    20th International Congress of the Polish Pharmacological Society (rok: 2019, ), Wydawca: Polish Pharmacological Society
    Data:
    konferencja 5-7.06.2019
    Status:
    Published
  2. Changes in the brain expression of NR2B subunit in different conditions of cocaine forced abstinence.
    Authors:
    Smaga I., Wydra K., Caffino L., Fumagalli F., Sanak M., Filip M.
    Conference:
    3rd Central European Biomedical Congress News on biomarker discovery and research innovations in medicine and biomedical sciences" , Krakow (rok: 2018, ), Wydawca: CEBC, Krakow
    Data:
    konferencja 15-18.09
    Status:
    Published
  3. Effects of Tat-NR2B9c on cocaine-seeking behavior in rat model.
    Authors:
    Witek K, Wydra K, Smaga I, Surówka P, Filip M.
    Conference:
    4th Central European Biomedical Congress (rok: 2021, ), Wydawca: CEBC
    Data:
    konferencja 7-9.06
    Status:
    Published
  4. Interaction of PSD95 with GluN2B subunit in different conditions of cocaine forced abstinence in rat brain structures.
    Authors:
    Smaga I., Wydra K., Caffino L., Fumagalli F., Sanak M., Filip M.
    Conference:
    INTERNATIONAL COLLEGE OF NEUROPSYCHOPHARMACOLOGY (CINP) WORLD CONGRESS, ATENY, GRECJA (rok: 2019, ), Wydawca: CINP
    Data:
    konferencja 3-5.10.2019
    Status:
    Published

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