Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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A study of a potential role of NANOS proteins in orchestrating 3'UTR-mediated translational regulation of functionally related mRNAs in human germ cells: A quest for the mechanism underlying speecificity of mammalian posttranscriptional regulons

2014/15/B/NZ1/03384

Keywords:

NANOS PUMILIO posttranscriptional regulon

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_11: Other related subjects

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Genetyki Człowieka PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Kamila Kusz-Zamelczyk 

Number of co-investigators in the project: 3

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 075 900 PLN

Project start date (Y-m-d): 2015-08-07

Project end date (Y-m-d): 2019-08-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer typu laptop (7 000 PLN)
  2. Rotator (3 500 PLN)
  3. Ssak medyczny (2 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (7)
  1. Human NANOS1 Represses Apoptosis by Downregulating Pro-Apoptotic Genes in the Male Germ Cell Line
    Authors:
    Janecki DM, Ilaslan E, Smialek MJ, Sajek M, Kotecki M, Ginter-Matuszewska B, Krainski P, Jaruzelska J and Kusz-Zamelczyk K
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 3009), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms21083009 - link to the publication
  2. Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model
    Authors:
    Smialek MJ, Ilaslan E, Sajek M, Swiercz A, Janecki DM, Kusz-Zamelczyk K, Wozniak T, Kotecki M, Handschuh L, Figlerowicz M and Jaruzelska J
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 984), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/cells9040984 - link to the publication
  3. Emerging roles of NANOS RNA-binding proteins in cancer
    Authors:
    Erkut Ilaslan, Marcin Piotr Sajek, Jadwiga Jaruzelska, Kamila Kusz-Zamelczyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 9408), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms23169408 - link to the publication
  4. Distinct Roles of NANOS1 and NANOS3 in the Cell Cycle and NANOS3-PUM1-FOXM1 Axis to Control G2/M Phase in a Human Primordial Germ Cell Model
    Authors:
    Erkut Ilaslan, Krystyna Kwiatkowska, Maciej Jerzy Smialek, Marcin Piotr Sajek, Zaneta Lemanska, Matisa Alla, Damian Mikolaj Janecki, Jadwiga Jaruzelska and Kamila Kusz-Zamelczyk
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 6592), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms23126592 - link to the publication
  1. Dysregulation of apoptosis by mutated RNA-binding protein NANOS1 and its significance for human male reproduction
    Authors:
    Janecki DM, Smialek MJ, Ilaslan E, Sajek MP, Spik A, Kusz-Zamelczyk K and Jaruzelska J.
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 6-11. 07.
    Status:
    Published
    DOI:
    link to the publication
  2. Global analysis of molecular interactions underlying functions of NANOS1 and NANOS3 proteins in the human germ cell model
    Authors:
    Ilaslan E, Maciej Smialek MJ, Sajek MP, Janecki DM, Spik A, Woźniak T, Kotecki M, Kusz-Zamelczyk K.
    Conference:
    24th Annual Meeting of the RNA Society (rok: 2019, ), Wydawca: RNA Society
    Data:
    konferencja 11-16. 06.
    Status:
    Published
  3. NANOS1 and NANOS3 paralogues repress distinct somatic pathways in human germ cells
    Authors:
    Ilaslan E, Smialek MJ, Sajek M, Janecki DM, Wozniak T, Spik A, Kotecki M, Kusz-Zamelczyk K
    Conference:
    BIO Congress 2018 (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  4. A global identification of genes regulated by PUM1 and PUM2 RNA-binding proteins in human seminoma TCam-2 cell line
    Authors:
    Smialek MJ, Sajek M, Swiercz A, Kotecki M, Janecki DM, Ilaslan E, Kusz-Zamelczyk K, Wozniak T, Handschuh L, Figlerowicz M, Jaruzelska J.
    Conference:
    IX Zjazd Polskiego Towarzystwa Genetyki Człowieka (rok: 2018, ), Wydawca: Polskie Towarzystwo Genetyki Człowieka
    Data:
    konferencja 13-15. 09.
    Status:
    Published
  5. Bioinformatic construction of PUM1 and PUM2 RNA-Regulons in TCam-2 cell line
    Authors:
    Smialek MJ, Sajek M, Swiercz A, Ilaslan E, Janecki DM, Kotecki M, Kusz-Zamelczyk K, Wozniak T, Handschuh L, Figlerowicz M, Jaruzelska J
    Conference:
    BIO Congress 2018 (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21.09.2018
    Status:
    Published
    DOI:
    link to the publication
  6. Distinct roles of NANOS1 and NANOS3 in regulating the cell cycle in a human germ cell model and its implications for infertility and cancer
    Authors:
    Erkut Ilaslan, Krystyna Kwiatkowska, Maciej Jerzy Smialek, Marcin Piotr Sajek, Matisa Alla, Damian Mikolaj Janecki, Zaneta Lemanska, Jadwiga Jaruzelska and Kamila Kusz-Zamelczyk
    Conference:
    VI Polski Kongres Gentyki (rok: 2022, ), Wydawca: Polskie Towarzystwo Genetyczne, Polskie Towarzystwo Genetyki Człowieka
    Data:
    konferencja 27-30. 06.
    Status:
    Published
  7. RNA-binding protein NANOS1 is necessary for regulation of mRNAs encoding apoptotic pathways in human germ cells
    Authors:
    Janecki DM, Smialek MJ, Ilaslan E, Sajek MP, Spik A, Kusz-Zamelczyk K and Jaruzelska J.
    Conference:
    24th Annual Meeting of the RNA Society (rok: 2019, ), Wydawca: RNA Society
    Data:
    konferencja 11-16. 06.
    Status:
    Published

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