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Information on the principal investigator and host institution

Information of the project and the call

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BCL11b - Potential Therapeutic Target in T cell Neoplasms

2013/09/B/NZ1/01867

Keywords:

BCL11B T-ALL PTCL/L T cells mice therapy

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_5: Genetic engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Genetyki Człowieka PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grzegorz Przybylski 

Number of co-investigators in the project: 4

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 676 000 PLN

Project start date (Y-m-d): 2014-02-20

Project end date (Y-m-d): 2017-12-19

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  1. The N-terminal CCHC zinc finger motif mediates homodimerization of the transcription factor BCL11B
    Authors:
    Grabarczyk P, Winkler P, Delin M, Sappa PK, Bekeschus S, Hildebrandt P, Przybylski GK, Völker U, Hammer E, Schmidt CA
    Academic press:
    Molecular and Cellular Biology (rok: 2018, tom: 38, strony: e00368-17), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/MCB.00368-17 - link to the publication
  2. Generation of Inducible BCL11B Knockout in TAL1/LMO1Transgenic Mouse T Cell Leukemia/Lymphoma Model
    Authors:
    Przybylski GK, Korsak D, Izykowska K, Nowicka K, Zalewski T, Tubacka M, Mosor M, Januszkiewicz-Lewandowska D, Frydrychowicz M, Boruczkowski M, Dworacki G, van den Brandt J, Grabarczyk P, Schmidt CA, Zeng C, Li Y
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 4923: 1-10), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23094932 - link to the publication
  3. Mouse Models to Study Genes Involved in Hematological Malignancies
    Authors:
    Przybylski GK
    Academic press:
    Blood Science (rok: 2020, tom: 2, strony: 50-53), Wydawca: Wolters Kluwer / Lippincott Williams & Wilkins
    Status:
    Published
    DOI:
    10.1097/BS9.0000000000000044 - link to the publication
  4. Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemia
    Authors:
    Li K, Chen C, Gao R, Yu X, Huang Y, Chen Z, Liu Z, Chen S, Luo G, Huang X, Przybylski GK, Li Y, Zeng C.
    Academic press:
    Biomarker Research (rok: 2021, tom: 9, strony: 17:1-4), Wydawca: BioMed Central Ltd part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s40364-021-00270-3 - link to the publication
  5. Novel targeted therapies of T cell lymphomas
    Authors:
    Iżykowska K, Rassek K, Korsak D, Przybylski GK.
    Academic press:
    Journal of Hematology and Oncology (rok: 2020, tom: 13, strony: 176:1-38), Wydawca: BioMed Central Ltd part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s13045-020-01006-w - link to the publication

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