Projects funded by the NCN

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53 projects found matching your search criteria :

  1. New approaches towards modulating selective and functional activities of antisense oligonucleotides

    Call: OPUS 2 , Panel: ST5

    Principal investigator: prof. Ryszard Kierzek

    Instytut Chemii Bioorganicznej PAN

  2. "RNA toxicity in pathogenesis of polyglutamine diseases"

    Call: MAESTRO 3 , Panel: NZ1

    Principal investigator: dr hab. Maciej Figiel

    Instytut Chemii Bioorganicznej PAN

  3. Identification of molecular mechanisms involved in soybean's cold stress response in temperate climate conditions.

    Call: OPUS 8 , Panel: NZ9

    Principal investigator: prof. Tomasz Twardowski

    Instytut Chemii Bioorganicznej PAN

  4. Comprehensive analysis of the therapeutic potential of oligonucleotides for the treatment of polyglutamine diseases

    Call: SONATA 9 , Panel: NZ5

    Principal investigator: dr hab. Agnieszka Fiszer

    Instytut Chemii Bioorganicznej PAN

  5. catalytic nucleic acids in of the new generation in the regulation of genetic information

    Call: OPUS 9 , Panel: ST5

    Principal investigator: prof. Jan Barciszewski

    Instytut Chemii Bioorganicznej PAN

  6. Thrombotic Mechanisms in Human Cystathionine β-Synthase Deficiency

    Call: OPUS 1 , Panel: NZ1

    Principal investigator: prof. Hieronim Jakubowski

    Instytut Chemii Bioorganicznej PAN

  7. Establishment of a novel scientific workshop enabling complex analysis of RNA degradome - elaboration of innovative meth...

    Call: SONATA 3 , Panel: NZ2

    Principal investigator: dr Paulina Jackowiak

    Instytut Chemii Bioorganicznej PAN

  8. Plant secondary metabolites controlling microbial colonizers.

    Call: SONATA BIS 2 , Panel: NZ2

    Principal investigator: dr hab. Paweł Bednarek

    Instytut Chemii Bioorganicznej PAN

  9. Ribozymes as a new tool for mitochondrial genome research

    Call: OPUS 5 , Panel: NZ1

    Principal investigator: prof. Jan Barciszewski

    Instytut Chemii Bioorganicznej PAN

  10. Dynasty and population of the Piast State in view of the integrated historical, anthropological and genomic studies

    Call: SYMFONIA 2 , Panel: NZ2

    Principal investigator: prof. Marek Figlerowicz

    Instytut Chemii Bioorganicznej PAN

  11. Long term survival and oxidative stress in hyperhomocysteinemia

    Call: SONATA 9 , Panel: NZ5

    Principal investigator: dr Marta Sikora

    Instytut Chemii Bioorganicznej PAN

  12. Analysis of the role of BARD1 gene in genetic predisposition to breast cancer - utilization of unique strategy of associ...

    Call: OPUS 9 , Panel: NZ2

    Principal investigator: prof. Piotr Kozłowski

    Instytut Chemii Bioorganicznej PAN

  13. The use of genetic tools in experimental therapy of polyglutamine diseases.

    Call: SONATA BIS 5 , Panel: NZ2

    Principal investigator: dr hab. Marta Olejniczak

    Instytut Chemii Bioorganicznej PAN

  14. Mechanisms underlying the targeting of coding sequence repeats by microRNA-like inhibitors

    Call: OPUS 8 , Panel: NZ1

    Principal investigator: dr Agnieszka Fiszer

    Instytut Chemii Bioorganicznej PAN

  15. Role of hyperhomocysteinemia in scent signalling in mice

    Call: PRELUDIUM 8 , Panel: NZ5

    Principal investigator: Jacek Wróblewski

    Instytut Chemii Bioorganicznej PAN

  16. Application of tandem mass spectrometry with collision-induced dissociation for profiling and structural analysis of phe...

    Call: PRELUDIUM 1 , Panel: NZ2

    Principal investigator: dr Anna Wojakowska

    Instytut Chemii Bioorganicznej PAN

  17. Structure - activity relationship studies of new flavonoids derivatives as the inhibitors of the bacterial tyrosyl-tRNA ...

    Call: PRELUDIUM 3 , Panel: NZ7

    Principal investigator: dr Mirosława Skupińska

    Instytut Chemii Bioorganicznej PAN

  18. New 3,8-disubstituted purine nucleoside analogues as prospective application for research of structure and biological ac...

    Call: SONATA 3 , Panel: ST5

    Principal investigator: dr hab. Anna Pasternak

    Instytut Chemii Bioorganicznej PAN

  19. Multilevel approach to reveal elucive molecular basis of herbicide stress response in maize

    Call: MAESTRO 3 , Panel: NZ9

    Principal investigator: prof. Tomasz Twardowski

    Instytut Chemii Bioorganicznej PAN

  20. Structure defined oligonucleotides for revealing fundamental insights into structure and function of RNAs

    Call: MAESTRO 4 , Panel: ST5

    Principal investigator: prof. Ryszard Kierzek

    Instytut Chemii Bioorganicznej PAN

  21. Evolutionary modeling physicochemical conditions for overexpression of viral replicons in plant liquid cultures

    Call: SONATA 5 , Panel: NZ1

    Principal investigator: dr Radosław Pilarski

    Instytut Chemii Bioorganicznej PAN

  22. Defining new neurodegeneration mechanisms using the first SCA3/MJD knock-in mouse model.

    Call: SONATA BIS 3 , Panel: NZ4

    Principal investigator: dr hab. Maciej Figiel

    Instytut Chemii Bioorganicznej PAN

  23. Imaging miRNA biogenesis pathway and cellular localization of RNA interference triggers

    Call: PRELUDIUM 9 , Panel: NZ3

    Principal investigator: dr Martyna Urbanek-Trzeciak

    Instytut Chemii Bioorganicznej PAN

  24. MicroRNA profiling in cellular models of Huntington's disease generated using iPSC technology

    Call: PRELUDIUM 9 , Panel: NZ2

    Principal investigator: Emilia Kozłowska

    Instytut Chemii Bioorganicznej PAN

  25. Pathophysiological consequences of histone N-homocysteinylation in hyperhomocysteinemia caused by CBS deficiency

    Call: PRELUDIUM 8 , Panel: NZ5

    Principal investigator: Izabela Lewandowska

    Instytut Chemii Bioorganicznej PAN

  26. Conserved RNA structural motifs in influenza virus: toward revealing viral RNA functions

    Call: HARMONIA 4 , Panel: NZ1

    Principal investigator: dr hab. Elżbieta Kierzek

    Instytut Chemii Bioorganicznej PAN

  27. Molekularna oraz behawioralna charakterystyka nowych mysich modeli ataksji rdzeniowo-móżdżkowej typu 3 (SCA3)

    Call: ETIUDA 1 , Panel: NZ4

    Principal investigator: Paweł Świtoński

    Instytut Chemii Bioorganicznej PAN

  28. ABA transport in legumes - between drought stress responses and nitrogen fixation efficiency

    Call: HARMONIA 5 , Panel: NZ3

    Principal investigator: dr hab. Michał Jasiński

    Instytut Chemii Bioorganicznej PAN

  29. Essential features of miRNA precursors required for release of homogenous siRNAs from shRNA-miR vectors.

    Call: PRELUDIUM 6 , Panel: NZ1

    Principal investigator: dr Paulina Gałka-Marciniak

    Instytut Chemii Bioorganicznej PAN

  30. Elucidation of the mechanisms that induce copy number polymorphism of large genome fragments and of the relations betwee...

    Call: OPUS 7 , Panel: NZ2

    Principal investigator: prof. Marek Figlerowicz

    Instytut Chemii Bioorganicznej PAN

  31. Structure and function of Glod4 protein

    Call: PRELUDIUM 9 , Panel: NZ3

    Principal investigator: Olga Utyro

    Instytut Chemii Bioorganicznej PAN

  32. Structural studies of proteins crucial for tick-mammal-pathogen interactions.

    Call: OPUS 9 , Panel: NZ1

    Principal investigator: prof. Mariusz Jaskólski

    Instytut Chemii Bioorganicznej PAN

  33. Molecular mechanisms underlying loss of a defensive metabolic pathway in a phylogenetic clade of plant species closely r...

    Call: OPUS 9 , Panel: NZ1

    Principal investigator: dr hab. Paweł Bednarek

    Instytut Chemii Bioorganicznej PAN

  34. Determining the secondary structure and function of BC200 in human brain tumor.

    Call: PRELUDIUM 1 , Panel: NZ3

    Principal investigator: Patrycja Sosińska

    Instytut Chemii Bioorganicznej PAN

  35. A new gereration of anticancer pronucleotides

    Call: OPUS 1 , Panel: NZ4

    Principal investigator: prof. Jacek Stawiński

    Instytut Chemii Bioorganicznej PAN

  36. Development of stereospecific phosphorylating agents containing nucleophilic catalytic groups

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr hab. Michał Sobkowski

    Instytut Chemii Bioorganicznej PAN

  37. Analysis of the epigenome and proteome in Zea mays lines resistant and sensitive to a herbicide.

    Call: SONATA 1 , Panel: NZ9

    Principal investigator: dr Agata Tyczewska

    Instytut Chemii Bioorganicznej PAN

  38. Analysis of the plasma proteome in chronic kidney disease in the context of progressive cardiovascular disease.

    Call: OPUS 3 , Panel: NZ2

    Principal investigator: dr Magdalena Łuczak

    Instytut Chemii Bioorganicznej PAN

  39. Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups

    Call: OPUS 4 , Panel: ST5

    Principal investigator: dr hab. Marcin Chmielewski

    Instytut Chemii Bioorganicznej PAN

  40. Study of the capabilities and limits of the use of Petri nets for modeling and analysis of complex biological systems on...

    Call: OPUS 4 , Panel: ST6

    Principal investigator: prof. Piotr Formanowicz

    Instytut Chemii Bioorganicznej PAN

  41. Evolution of Brassicaceae plant secondary metabolites essential in plant immunity.

    Call: PRELUDIUM 5 , Panel: NZ2

    Principal investigator: Karolina Kułak

    Instytut Chemii Bioorganicznej PAN

  42. The role of the 5' non-coding regions of p53 mRNA transcripts, which are synthesized from various transcription promoter...

    Call: OPUS 5 , Panel: NZ1

    Principal investigator: prof. Jerzy Ciesiołka

    Instytut Chemii Bioorganicznej PAN

  43. Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification.

    Call: SONATA BIS 3 , Panel: NZ1

    Principal investigator: dr hab. Anna Pasternak

    Instytut Chemii Bioorganicznej PAN

  44. RNA hybrid duplex-quadruplex structures with dual functionality as a new tool for silecing of gene expression

    Call: OPUS 7 , Panel: ST5

    Principal investigator: prof. Zofia Gdaniec

    Instytut Chemii Bioorganicznej PAN

  45. Understanding the mechanism of action for small molecule kinase inhibitors in alleviating myotonic dystrophy type 1 (DM1...

    Call: OPUS 7 , Panel: NZ5

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej PAN

  46. Identification of circular RNAs and protein factors involved in their biogenesis in a model plant, Arabidopsis thaliana

    Call: SONATA 8 , Panel: NZ2

    Principal investigator: dr Anna Philips

    Instytut Chemii Bioorganicznej PAN

  47. RNA hairpin structures in biology and pathogenesis. Crystallographic analysis.

    Call: OPUS 1 , Panel: NZ1

    Principal investigator: prof. Wojciech Rypniewski

    Instytut Chemii Bioorganicznej PAN

  48. Copy number polymorphism as a major mechanism influencing variability of plant genomes. Endogenous (RNA interference) an...

    Call: OPUS 1 , Panel: NZ2

    Principal investigator: prof. Marek Figlerowicz

    Instytut Chemii Bioorganicznej PAN

  49. RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibito...

    Call: SONATA 1 , Panel: NZ1

    Principal investigator: dr Katarzyna Pachulska-Wieczorek

    Instytut Chemii Bioorganicznej PAN

  50. Aryl nucleoside phosphoroamidates - a new generation of anti-HIV pronucleotides.

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Jacek Stawiński

    Instytut Chemii Bioorganicznej PAN

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