Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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New insights into the docking interactions between thioflavin T and misfolded proteins

2011/03/N/ST4/00736

Keywords:

thioflavin T conformational transitions in proteins amyloid induced circular dichroism

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Viktoria Babenko 

Number of co-investigators in the project: 2

Call: PRELUDIUM 2 - announced on 2011-09-15

Amount awarded: 139 620 PLN

Project start date (Y-m-d): 2012-08-20

Project end date (Y-m-d): 2014-02-19

Project duration:: 18 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. Dimethyl Sulfoxide Induced Destabilization and Disassembly of Various Structural Variants of Insulin Fibrils Monitored by Vibrational Circular Dichroism
    Authors:
    Zhang G., Babenko V., Dzwolak W., Keiderling T. A.
    Academic press:
    Biochemistry (rok: 2015, tom: 54, strony: 7193-7202), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.biochem.5b00809 - link to the publication
  2. On the Function and Fate of Chloride Ions in Amyloidogenic Self-Assembly of Insulin in an Acidic Environment: Salt-Induced Condensation of Fibrils
    Authors:
    Babenko V., Surmacz-Chwedoruk W., Dzwolak W.
    Academic press:
    Langmuir (rok: 2015, tom: 31, strony: 2180–2186), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/la5048694 - link to the publication
  3. Molecules of Congo Red caught hopping between insulin fibrils: A chiroptical probe of the dye-amyloid binding dynamics
    Authors:
    Dec R., Babenko V., Dzwolak W.
    Academic press:
    RSC Advances , Wydawca: Royal Society of Chemistry
    Status:
    Submitted