Projects funded by the NCN


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55 projects found matching your search criteria :

  1. In the search for active compounds among ligands of serotonin, particularly 5-HT7, and dopamine receptors, with potentia...

    Call: OPUS 1 , Panel: NZ4

    Principal investigator: prof. Anna Wesołowska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  2. Structure-adrenolytic activity relationship among racemic and chiral analogues of 1-(1H-indol-4-iloksy)-3-(2-(2-metoksyf...

    Call: SONATA 1 , Panel: NZ4

    Principal investigator: dr Marek Bednarski

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  3. The search for new substances with anticonvulsant and antinociceptive activity among hybrid compounds based on the pyrro...

    Call: SONATA BIS 5 , Panel: NZ7

    Principal investigator: dr hab. Krzysztof Kamiński

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  4. Multifunctional inhibitors of beta-secretase with anti-aggregating properties of neurotoxic peptides - beta-amyloid and ...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: prof. Barbara Malawska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  5. In Search for the novel therapeutic strategies in the treatment of brain ischemia. Determination of the neuroprotective ...

    Call: SONATA 11 , Panel: NZ4

    Principal investigator: dr Bartosz Pomierny

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  6. GPR18 orphan receptor. Search for the tools to investigate GPR18 as potential therapeutic target

    Call: OPUS 6 , Panel: NZ7

    Principal investigator: prof. Katarzyna Kieć-Kononowicz

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  7. Functionalized amino acids - inibitors of GABA uptake with antianalgetic activity

    Call: OPUS 8 , Panel: NZ7

    Principal investigator: dr Paula Zaręba

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  8. Insight into the properties of polymeric matrices containig active pharmaceutical ingredients obtained by means of 3D pr...

    Call: OPUS 16 , Panel: ST8

    Principal investigator: prof. Renata Jachowicz

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  9. Personalized therapy - design and verification of the optimalization and manufacturing of the modified release, orally t...

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: prof. Sebastian Polak

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  10. Evaluation of the protective capacity of resveratrol and quercetin in models of neurotoxicity induced by aluminum and ma...

    Call: OPUS 1 , Panel: NZ4

    Principal investigator: dr Maciej Gawlik

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  11. Partial agonists alpha1A/D-adrenoceptors as potential compounds that improve urodynamic parameters in benign prostatic h...

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: dr hab. Jacek Sapa

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  12. LCAP biomimetics - alicyclic amine derivatives as a new class of monoaminergic receptor ligands

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr hab. Paweł Zajdel

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  13. Hydantoin derivatives in a fight with drug resistance of bacteria

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: Anna Matys

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  14. The determination of ADME-Tox in vitro for potential CNS-drug candidates acting as potent and selective ligands of serot...

    Call: PRELUDIUM 11 , Panel: NZ7

    Principal investigator: Annamaria Lubelska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  15. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Anna Więckowska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  16. Interaction and PK/PD studies of phosphodiesterase inhibitors in a murine model of autoimmune hepatitis

    Call: PRELUDIUM 15 , Panel: NZ7

    Principal investigator: dr Artur Świerczek

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  17. Antimicrobial and antibiofilm properties of novel arylosulfonamide derivates towards multidrug-resistant and biofilm-for...

    Call: PRELUDIUM 16 , Panel: NZ6

    Principal investigator: Iwona Skiba-Kurek

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  18. Estimation of surrogate of the effective drug concentration responsible for cardiac electrophysiological effect - numeri...

    Call: PRELUDIUM 7 , Panel: NZ7

    Principal investigator: Zofia Tylutki

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  19. New selective antagonists of ionotropic glutamate non-NMDA receptors

    Call: OPUS 8 , Panel: NZ7

    Principal investigator: dr Ewa Szymańska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  20. Ocena neurotoksycznego działania eterów glikolu etylenowego - badania in vitro oraz in vivo.

    Call: ETIUDA 2 , Panel: NZ7

    Principal investigator: Bartosz Pomierny

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  21. The mechanism of neurotoxic action of benzophenone-3

    Call: OPUS 8 , Panel: NZ7

    Principal investigator: prof. Bogusława Budziszewska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  22. Search for the functionally selective 5-HT1A receptor agonists as new pharmacological tools in the development of treatm...

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: prof. Marcin Kołaczkowski

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  23. Biased inverse agonists of 5-HT6 receptor and dual 5-HT6/MAO-B inhibitors - in search for new therapeutic approaches for...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: prof. Paweł Zajdel

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  24. New amide derivatives of cinnamic acid as a carbonyl reductase inhibitors, which modulate the activity of doxorubicin - ...

    Call: SONATA 11 , Panel: NZ7

    Principal investigator: dr Paulina Koczurkiewicz-Adamczyk

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  25. 7,8-disubstituted theophylline derivatives that are potent inhibitors of selected PDE isoenzymes as a new compounds with...

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr Katarzyna Wójcik-Pszczoła

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  26. New vanilloid type 1 receptor (TRPV1) antagonists in the search for substances with wide-spectrum of anticonvulsant and ...

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr hab. Krzysztof Kamiński

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  27. The role of GPR39 receptor in the mechanism of antidepressant action

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: dr Katarzyna Młyniec

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  28. Multifunctional ligands - TRPA1 channel antagonists and phosphodiesterases inhibitors as a new approach for the treatmen...

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: dr hab. Grażyna Chłoń-Rzepa

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  29. New hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)-propanamide in the search for substances effective in tre...

    Call: PRELUDIUM 15 , Panel: NZ7

    Principal investigator: Michał Abram

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  30. Evaluation of therapeutic role of novel positive allosteric modulators of GABA-A receptor in ischemic brain stroke

    Call: SONATA BIS 8 , Panel: NZ7

    Principal investigator: dr Monika Marcinkowska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  31. Searching for molecular basis of addiction-prone phenotype - a role of astrocyte biomarkers (xc-, EAAT2) and metabotropi...

    Call: PRELUDIUM 6 , Panel: NZ7

    Principal investigator: Ewa Niedzielska-Andres

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  32. Effect of modulation of the GPR39 zinc receptor on glutamatergic and gabaergic transmission in the context of antidepres...

    Call: PRELUDIUM 11 , Panel: NZ7

    Principal investigator: Gabriela Starowicz

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  33. Modeling of structure of gamma-aminobutyric acid transporters as an essential biological and therapeutic target

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Marek Bajda

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  34. Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Katarzyna Szczepańska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  35. New perspective in Alzheimer's disease therapy - multifunctional histamine H3 receptor ligands?

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: dr hab. Dorota Łażewska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  36. Partial agonists of alpha-2 adrenoceptors as new perspective of the effective and safe in reducting body weight and obes...

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: dr Magdalena Dudek

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  37. Search for new "drug-like" molecules designed as adenosine receptors ligands

    Call: HARMONIA 2 , Panel: NZ4

    Principal investigator: prof. Katarzyna Kieć-Kononowicz

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  38. Novel dual PDE4 and PDE7 inhibitors in a group of purine and deazapurine derivatives - perspective for the treatment of ...

    Call: OPUS 8 , Panel: NZ7

    Principal investigator: prof. Maciej Pawłowski

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  39. Synthesis and pharmacological evaluation of novel benzizoxazolepropylpyrolidine derivatives as multifunctional ligands w...

    Call: SONATA 8 , Panel: NZ7

    Principal investigator: dr Monika Marcinkowska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  40. Non-quinazoline antagonists of apha1 and 5-HT2A receptors with pleiotropic effects as a new perspective for hypertension...

    Call: SONATA 8 , Panel: NZ7

    Principal investigator: dr Monika Kubacka

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  41. Evaluation of pharmacological activity of new, nonselective gamma-aminobutyric acid (GABA) transport inhibitors in some ...

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr hab. Kinga Sałat

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  42. In vitro/in vivo characteristics of hydrophilic matrix containing phosphodiesterase-5 inhibitors.

    Call: SONATA 4 , Panel: NZ7

    Principal investigator: dr Anna Krupa

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  43. Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

    Call: OPUS 4 , Panel: NZ7

    Principal investigator: prof. Maciej Pawłowski

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  44. Search for new compounds active in central nervous system

    Call: OPUS 6 , Panel: NZ7

    Principal investigator: dr hab. Anna Waszkielewicz

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  45. Phytochemical and biotechnological studies and evaluation of biological activity of magnolia vine species - Schisandra r...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Szopa

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  46. Functional selectivity of novel histamine H4 receptor ligands

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Agnieszka Olejarz-Maciej

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  47. Traizine 5-HT6 receptor ligands - new perspective for therapy of current civilization CNS-diseases

    Call: OPUS 9 , Panel: NZ7

    Principal investigator: dr hab. Jadwiga Handzlik

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  48. Synthesis and pharmacological characterization of structurally diverse chemical analogues of compound PO-10 as multiple ...

    Call: SONATA 11 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Zagórska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  49. Development of a group of non-basic ligands of serotonin receptor 5-HT7, derivatives of 2-(6-oxo-3-phenyl-1,6-dihydropyr...

    Call: SONATINA 2 , Panel: NZ7

    Principal investigator: dr Sabina Podlewska

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

  50. Novel alkyne derivatives of Safirinium probes: fluorescent labelling of azidothymidine in click chemistry conception

    Call: PRELUDIUM 15 , Panel: NZ7

    Principal investigator: dr Patryk Kasza

    Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny