Projects funded by the NCN

Targeting MMP-9 in Cancer Treatment: Computational Design and Experimental Validation of Potent, Safe Antitumor Agents

Call: SONATA BIS 15 , Panel: ST5

Principal investigator: dr Anna Żądło-Dobrowolska

Instytut Chemii Organicznej Polska Akademia Nauk

Development of Molecular and Supramolecular Tools to Exploit Human Copper(I) Homeostasis for Cancer Therapeutics

Call: SONATA BIS 15 , Panel: ST5

Principal investigator: dr JEENA Manayath Thekkeyil

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Integrative analysis of tRNA modification circuits and aminoacylation and their role in breast cancer model.

Call: OPUS 29 , Panel: NZ2

Principal investigator: dr Marcin Sajek

Instytut Genetyki Człowieka PAN

FHOD1 as a Regulator of Lipid Droplet–Mitochondria Interactions: A New Dimension of Metabolic Control in Skin Melanoma C...

Call: OPUS 29 , Panel: NZ3

Principal investigator: dr hab. Antonina Joanna Mazur

Uniwersytet Wrocławski

The role of CXXC5 in the epigenetic profile of Hodgkin lymphoma

Call: PRELUDIUM 24 , Panel: NZ2

Principal investigator: Daniel Sikora

Instytut Genetyki Człowieka PAN

Role of the BRM- ERα interaction in the conferring of resistance to paclitaxel in BRG1-deficient cancers

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Karolina Gronkowska

Uniwersytet Łódzki

Effect of dietary modulation of RAGE/AGE axis on prostatic neuroendocrine differentiation and the efficacy of anticancer...

Call: OPUS 29 , Panel: NZ7

Principal investigator: dr Wawrzyniec Dobrucki

Gdański Uniwersytet Medyczny

Genetic factors influencing response to immunotherapy and prognosis in patients with melanoma brain metastases

Call: PRELUDIUM 24 , Panel: NZ2

Principal investigator: Piotr Jan Błoński

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Molecular pathways involved in nuclear membrane stress adaptation and its role in breast and prostate cancer

Call: OPUS 29 , Panel: NZ3

Principal investigator: dr Paulina Nastały

Gdański Uniwersytet Medyczny

M. bovis BCG extracellular vesicles as an alternative in bladder cancer immunotherapy

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Jakub Smoliński

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

TP53 mutations drive alternative FGFR1 splicing - the study of consequences for cancer progression and therapeutic oppor...

Call: PRELUDIUM 24 , Panel: NZ4

Principal investigator: Weronika Wojtyś

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Development of Red-Emitting Chiral Carbon Dots for Advanced Photodynamic Therapy (PDT)

Call: PRELUDIUM 24 , Panel: ST8

Principal investigator: Patryk Szymaszek

Politechnika Krakowska im. Tadeusza Kościuszki

Small non-coding RNAs as early indicators of carcinogenesis in inherited DNA repair disorders

Call: PRELUDIUM 24 , Panel: NZ4

Principal investigator: Katarzyna Izabela Płoszka

Uniwersytet Medyczny w Łodzi

Development of the fluorescence multifunctional biosensing system based on antisense oligonucleotide probes for the onco...

Call: PRELUDIUM 24 , Panel: ST4

Principal investigator: Hubert Grzegorz Grel

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

Development of novel 1,3-selenazol-2-one derivatives incorporated into self-emulsifying drug delivery systems as a strat...

Call: OPUS 29 , Panel: NZ7

Principal investigator: dr hab. Robert Czarnomysy

Uniwersytet Medyczny w Białymstoku

Synergistic enhancement of reactive oxygen species generation via combination of heavy atom effect with donor-acceptor a...

Call: PRELUDIUM 24 , Panel: ST5

Principal investigator: Karolina Anna Urbanowicz

Politechnika Warszawska

Metabolic biomarkers of prostate cancer

Call: OPUS 29 , Panel: NZ7

Principal investigator: prof. Tomasz Łukasz Ruman

Politechnika Rzeszowska im. Ignacego Łukasiewicza

CTC-on-CAM: a platform for studying heterogeneity, epithelial-mesenchymal transition, and therapeutic sensitivity of cir...

Call: OPUS 29 , Panel: NZ7

Principal investigator: prof. Marek Arkadiusz Murias

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Dual cell cycle blockade and immune checkpoint inhibition as a potential strategy of sequential anticancer therapy

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Alicja Stanisława Słota

Uniwersytet Jagielloński

Personalized selective activation of γδT Vδ2 cells using zoledronic acid for glioblastoma MICA/Bhigh therapy: in vitro a...

Call: PRELUDIUM 24 , Panel: NZ4

Principal investigator: Natalia Anna Lehman

Uniwersytet Medyczny w Lublinie

LLT1 as a regulator of the immune response and a dual-target immunotherapy approach in colorectal cancer directed at NK ...

Call: OPUS 29 , Panel: NZ6

Principal investigator: dr Marzena Dorota Lenart

Uniwersytet Jagielloński

"The Role of Adipose Tissue and microRNA in the Progression of Clear Cell RenalCell Carcinoma".

Call: PRELUDIUM 24 , Panel: NZ4

Principal investigator: Dorota Małgorzata Kwapisz

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

UVC Persistent Phosphors for Next-Generation Photodynamic Cancer Therapy

Call: OPUS 29 , Panel: ST4

Principal investigator: dr Nadiia Rebrova

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego PAN

New approach to glioblastoma adoptive therapy based on inducible CAR expression system - SynCAR

Call: OPUS 29 , Panel: NZ6

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny

Rola TRIM32 i TRIM34 w regulacji metabolizmu guza i mikrośrodowiska immunologicznego w raku jajnika

Call: PRELUDIUM 24 , Panel: NZ6

Principal investigator: Alicja Katarzyna Rajtak

Uniwersytet Medyczny w Lublinie

The role of inflammation and sex-specific mechanisms in the development and progression of hepatocellular carcinoma

Call: OPUS 29 , Panel: NZ4

Principal investigator: dr hab. Katarzyna Miękus

Uniwersytet Jagielloński

We are Left Without Oxygen—Now What?: Evaluation of Hypoxia-Inducible COL Family Genes in Glioblastoma Patients and Thei...

Call: OPUS 29 , Panel: NZ4

Principal investigator: prof. Ewa Izabela Balcerczak

Uniwersytet Medyczny w Łodzi

The role of IFN-γ in inducing phenotype alterations and disulfidptosis in drug-naïve and BRAFV600/MEK inhibitor-resistan...

Call: PRELUDIUM 24 , Panel: NZ4

Principal investigator: Piotr Wawrzyniak

Uniwersytet Medyczny w Łodzi

Intestinal barrier dysfunction as a risk factor for pancreatic ductal adenocarcinoma: impact of fatty acid intake, with ...

Call: PRELUDIUM 24 , Panel: NZ4

Principal investigator: Wojciech Michał Jankowski

Uniwersytet Medyczny w Łodzi

New aryl difluoromethylenephosphonic acid and thiazole conjugates as effective PTP1B inhibitors used in the treatment of...

Call: PRELUDIUM 24 , Panel: ST5

Principal investigator: Dominika Agnieszka Kołodziej-Sobczak

Uniwersytet Mikołaja Kopernika

Influence of ER stress on the hormonal activity of pituitary neuroendocrine tumors (PitNETs)

Call: SONATINA 9 , Panel: NZ4

Principal investigator: dr Beata Krystyna Rak-Makowska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Artificial intelligence in predicting treatment outcomes of abdominal cancers – implementation of machine learning and d...

Call: SONATINA 9 , Panel: NZ7

Principal investigator: dr Krzysztof Bartnik

Politechnika Warszawska

Next-Generation Exosome Therapy: Engineering NK Cell-Derived Vesicles for Targeted Cancer Treatment

Call: SONATINA 9 , Panel: NZ6

Principal investigator: dr Daria Nawrocka

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Alterations in host protein trafficking during Human papillomavirus infection and oncogenesis

Call: WEAVE-UNISONO , Panel: NZ6

Principal investigator: dr hab. Justyna Karolina Broniarczyk

Uniwersytet im. Adama Mickiewicza w Poznaniu

Mind the gap! Plasmonic nanocavity for spectroscopic trapping of local molecularrearrangements in DNA upon epigenetic mo...

Call: OPUS 28 , Panel: ST4

Principal investigator: prof. Ewelina Wioletta Lipiec

Uniwersytet Jagielloński

Janus nanoparticles - research on the effect of the duality of carriers of the activesubstance in targeted therapy of sk...

Call: OPUS 28 , Panel: ST8

Principal investigator: dr hab. Bożena Anna Tyliszczak

Politechnika Krakowska im. Tadeusza Kościuszki

Novel insights into inhibition of PD-L1/PD-1 immune checkpoint – discovery and optimization of covalent PD-L1 inhibitors...

Call: SONATA 20 , Panel: ST5

Principal investigator: dr Radosław Dariusz Kitel

Uniwersytet Jagielloński

Investigation of the mechanism of enhanced liposome delivery to tumors and its application for dual target immunotherapy

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Tomasz Piotr Rygiel

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Environmental modulation of CDK4/6 inhibitor efficacy: Impact of mycotoxin alternariol exposure on anti-cancer therapies

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Anna Dominika Walczak-Szeffer

Uniwersytet Medyczny w Łodzi

Neutrophil Dynamics: Unveiling Anti-Tumor and Therapy Efficacy with the TUmor Neutrophil Immunotherapy on Chip (TUNIC) m...

Call: SONATA 20 , Panel: NZ6

Principal investigator: dr Martin Nurmik

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Human exosomes as natural carriers of protein kinase CK2 inhibitors and degraders in targeted anticancer therapy.

Call: OPUS 28 (LAP) , Panel: NZ5

Principal investigator: dr hab. Patrycja Joanna Wińska

Politechnika Warszawska

Analysis of the effects of proteotoxic stress on cholesterol homeostasis and its associations with cardiovascular diseas...

Call: OPUS 28 , Panel: NZ5

Principal investigator: prof. Wiesława Elżbieta Widłak

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Parallel microevolution of metabolic plasticity and chemoresistance of cancer cells: a key to understanding cancer relap...

Call: OPUS 28 , Panel: NZ3

Principal investigator: prof. Jarosław Piotr Czyż

Uniwersytet Jagielloński

Quad-TNT: Quadruplex-Targeted Photo-Therapy for Triple-Negative Tumors

Call: SONATA BIS 14 , Panel: NZ5

Principal investigator: dr Marco Deiana

Politechnika Wrocławska

Biomaterial enriched with propolis extract as a promising chemopreventive dressing material after melanoma excision

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Marta Trzaskowska

Uniwersytet Medyczny w Lublinie

Cellular effects in the tumor microenvironment and the potential for targeted delivery of molecules associated with the ...

Call: OPUS 27 , Panel: NZ4

Principal investigator: prof. Magdalena Maria Staniszewska

Katolicki Uniwersytet Lubelski Jana Pawła II

N6-methyladenine metabolism - potential relationships with the development of hematological malignancies.

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Marta Starczak

Uniwersytet Mikołaja Kopernika

Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Aleksandra Dorota Helbik-Maciejewska

Uniwersytet Gdański

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański

Identification of novel microRNA biomarkers in liquid biopsy of patients with neuroendocrine tumors

Call: PRELUDIUM 23 , Panel: NZ5

Principal investigator: Paweł Mateusz Komarnicki

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu