Projects funded by the NCN


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51 projects found matching your search criteria :

  1. Estrogen receptor GPER as a modulator of inflammatory and functional gastrointestinal diseases and colorectal cancer

    Call: PRELUDIUM 9 , Panel: NZ5

    Principal investigator: Damian Jacenik

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  2. Maturation, pharmacogenomics, and metabolomics as factors determining pharmacokinetic and pharmacodynamics profile of al...

    Call: OPUS 9 , Panel: NZ7

    Principal investigator: dr hab. Paweł Wiczling

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  3. COX-2 inhibitors and/or PPAR agonists-conjugated PAMAM G3 dendrimers targeted into cancer cells. Biological properties a...

    Call: SONATA 7 , Panel: NZ3

    Principal investigator: dr Łukasz Stanisław Uram

    Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

  4. Searching for alternative derivatizing agents for the trace analysis of pharmaceuticals in natural samples using gas chr...

    Call: PRELUDIUM 1 , Panel: ST4

    Principal investigator: dr Magda Ewa Caban

    Uniwersytet Gdański

  5. Molecular mechanisms of activation and modulation of recombinant GABAA receptors by selected agonists and modulators

    Call: OPUS 6 , Panel: NZ3

    Principal investigator: prof. Jerzy Władysław Mozrzymas

    Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

  6. Influence of antagonists (scopolamine and 3-quinuclidinyl benzilate) and agosists (carbachol) of muscarinic cholinergic ...

    Call: PRELUDIUM 5 , Panel: NZ9

    Principal investigator: Szymon Piotr Chowański

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  7. The influence of glucagon-like peptied-1 receptor agaonists on regulation of coticotropin-releasing hormone gene promote...

    Call: PRELUDIUM 4 , Panel: NZ7

    Principal investigator: Jan Stanisław Detka

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  8. Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric ...

    Call: SONATA 4 , Panel: NZ1

    Principal investigator: dr Dorota Latek

    Uniwersytet Warszawski, Wydział Chemii

  9. The influence of some selected antiepileptic drugs in combination with arachinodyl-2-chlorethylamide, a selective cannab...

    Call: OPUS 3 , Panel: NZ7

    Principal investigator: dr Marta Andres-Mach

    Instytut Medycyny Wsi im. Witolda Chodźki

  10. Influence of PPAR-gama receptor agonists on antitumor activity of photodynamic therapy.

    Call: PRELUDIUM 3 , Panel: NZ5

    Principal investigator: dr Piotr Marek Mrówka

    Warszawski Uniwersytet Medyczny, Wydział Nauki o Zdrowiu

  11. Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

    Call: PRELUDIUM 2 , Panel: ST5

    Principal investigator: Jolanta Dyniewicz

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  12. Conjugated linoleic acid (CLA)-induced transcriptional activation of PPAR-an investigation of molecular machanisms of pu...

    Call: OPUS 2 , Panel: NZ9

    Principal investigator: prof. Teresa Leszczyńska

    Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Technologii Żywności

  13. A triple agonist of glucagon, GLP-1, and GIP receptors as a novel therapeutic option for the treatment of heart failure ...

    Call: SONATA 20 , Panel: NZ5

    Principal investigator: dr Marta Katarzyna Oknińska

    Centrum Medyczne Kształcenia Podyplomowego

  14. Modulation of 5-HT7 receptor signaling as common mechanism involved in the long-lasting antidepressant effects of typica...

    Call: SONATA 20 , Panel: NZ7

    Principal investigator: dr Barbara Wanda Chruścicka-Smaga

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  15. Dual Se-containing 5-HT1A and 5-HT7 biased agonists activating sigma-1 receptor as a hope of finding fast-acting antidep...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: prof. Karolina Anna Pytka

    Uniwersytet Jagielloński

  16. Partial agonists alpha1A/D-adrenoceptors as potential compounds that improve urodynamic parameters in benign prostatic h...

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: dr hab. Jacek Paweł Sapa

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  17. Semaglutide and neurodevelopment: investigating risks arising from prenatal exposure to a widely popular drug for diabet...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Agnieszka Wnuk

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  18. Retro-inverso modification of zinc(II)–GLP-1 receptor agonist complexes – from bioinorganic chemistry to animal studies...

    Call: OPUS 26 , Panel: ST5

    Principal investigator: dr hab. Magdalena Alina Rowińska-Żyrek

    Uniwersytet Wrocławski, Wydział Chemii

  19. Argument Mining: Public Debate Models and Algorithmically-Assisted Argument Extraction

    Call: OPUS 25 , Panel: HS5

    Principal investigator: dr Rafał Olszowski

    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Humanistyczny

  20. Searching for natural bioactive farnesoid X receptor agonists and their role in parenteral nutrition-associated liver di...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr hab. Maciej Jan Stawny

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  21. The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Katarzyna Anna Szczepańska

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  22. Partial agonists of alpha-2 adrenoceptors as new perspective of the effective and safe in reducting body weight and obes...

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: dr Magdalena Bogumiła Dudek

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  23. The effect of chronic administration of purine P1-A2B receptor agonist, using electrospun microfibers, on intrarenal blo...

    Call: PRELUDIUM 21 , Panel: NZ5

    Principal investigator: Joanna Dorota Sitek-Dębska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  24. Dual 5-HT3 receptor/5-HT6 receptor antagonists in neuropsychiatric and neurological disorders

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: prof. Paweł Maria Zajdel

    Uniwersytet Jagielloński, Collegium Medicum

  25. New approach to the treatment of Alzheimer's disease targetingresolution of inflammation and modulation of biomechanical...

    Call: OPUS 22 , Panel: NZ4

    Principal investigator: prof. Agnieszka Basta-Kaim

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  26. First-in-class dual biased agonists of serotonin 5-HT1A and dopamine D2 receptors – an innovative approach in the search...

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Marcin Roman Kołaczkowski

    Uniwersytet Jagielloński, Collegium Medicum

  27. Self-learning systems in the design of compounds modulating GPCR receptors activation.

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr hab. Dorota Latek

    Uniwersytet Warszawski, Wydział Chemii

  28. The significance of circadian rhythm in urinary bladder cancer: deregulation of circadian genes as a putative therapeuti...

    Call: OPUS 19 , Panel: NZ5

    Principal investigator: prof. Edyta Wiesława Reszka

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  29. Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: dr Natalia Eleonora Małek-Chudzik

    Politechnika Wrocławska

  30. Investigation of novel functionally selective opioid receptors agonists

    Call: ETIUDA 8 , Panel: NZ7

    Principal investigator: Łucja Elżbieta Szumiec

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  31. Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: prof. Mariusz Papp

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  32. In vivo effects, underlying signaling pathways and mechanism of action of ghrelin receptor agonist against pathological ...

    Call: SONATA 15 , Panel: NZ7

    Principal investigator: dr Piotr Chmielarz

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  33. Quantitative assessment of vascular endothelial growth factor (VEGF) in serum, follicular fluid (FF) and VEGF mRNA in gr...

    Call: OPUS 1 , Panel: NZ5

    Principal investigator: prof. Artur Jacek Jakimiuk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  34. Searching for the background underlying the neuroprotective effects of the specific agonist of Y2 receptors - NPY(13-36)...

    Call: PRELUDIUM 17 , Panel: NZ4

    Principal investigator: Łukasz Przykaza

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  35. Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR...

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: dr hab. Marcin Marek Ratajewski

    Instytut Biologii Medycznej Polskiej Akademii Nauk

  36. Połączone działanie agonistów receptorów adenozynowych i antagonistów receptora P2Y12 zwiększa hamowanie funkcji płytek ...

    Call: ETIUDA 7 , Panel: NZ3

    Principal investigator: Nina Małgorzata Wolska

    Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

  37. Rational design and evaluation of functionally biased opioid agonists

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: prof. Ryszard Przewłocki

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  38. Searching for mu opioid receptor peptide agonists with G protein/beta-arrestin biased profile and their pharmacological ...

    Call: SONATA 14 , Panel: ST5

    Principal investigator: dr Justyna Piekielna-Ciesielska

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  39. Molecular mechanism of anticancer action of selected NSAIDs as a PPAR gamma receptor agonists in experimental models of ...

    Call: PRELUDIUM 14 , Panel: NZ7

    Principal investigator: Adam Kazberuk

    Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  40. Modulation of inflammatory processes using new agonists of the formyl peptide receptors ALX/FPR2 as a new therapeutic st...

    Call: HARMONIA 9 , Panel: NZ7

    Principal investigator: prof. Agnieszka Basta-Kaim

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  41. Development of unique molecular probes: low-basicity agonists for the study of 5-HT7 receptor function

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Andrzej Jacek Bojarski

    Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

  42. Concepts of Agonistic Democracy

    Call: PRELUDIUM 1 , Panel: HS5

    Principal investigator: Filip Biały

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Nauk Politycznych i Dziennikarstwa

  43. Investigation of the mechanisms of the neuroprotective effect of group II metabotropic receptors (mGluR2/3) agonist in a...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: dr Ewelina Małgorzata Bratek

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  44. Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Katarzyna Anna Szczepańska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  45. Molecular receptors as a tool for studies of interactions agonist/antagonist of H1 - H4 receptors

    Call: PRELUDIUM 11 , Panel: ST5

    Principal investigator: Małgorzata Ewa Walczak

    Politechnika Łódzka, Wydział Chemiczny

  46. Biased inverse agonists of 5-HT6 receptor and dual 5-HT6/MAO-B inhibitors - in search for new therapeutic approaches for...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: prof. Paweł Maria Zajdel

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  47. Phosphorylation of the A/B domain as the crucial mechanism involved in substrate specificity of the two isoforms (RORgam...

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: dr Marcin Marek Ratajewski

    Instytut Biologii Medycznej Polskiej Akademii Nauk

  48. Search for the functionally selective 5-HT1A receptor agonists as new pharmacological tools in the development of treatm...

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: prof. Marcin Roman Kołaczkowski

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  49. 5-HT6 receptor ligands as addition to antipsychotic therapy in schizophrenia - an impact on body weight, metabolic param...

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: prof. Anna Małgorzata Wesołowska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  50. Metabolic profiling of HIF stabilizers, PPAR agonists and SARMs by means of UPLC-MS/MS.

    Call: PRELUDIUM 9 , Panel: ST4

    Principal investigator: Katarzyna Kowalczyk

    Uniwersytet Warszawski, Wydział Chemii