Projects funded by the NCN

Dual cell cycle blockade and immune checkpoint inhibition as a potential strategy of sequential anticancer therapy

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Alicja Stanisława Słota

Uniwersytet Jagielloński

Targeted Degradation of the MLL Complex in Leukemia: A PROTAC-Based Therapeutic Strategy

Call: SONATINA 9 , Panel: ST5

Principal investigator: dr Natalia Anna Skrzypczak

Fundacja Uniwersytetu im. Adama Mickiewicza

Development of cIAP1-targeting CDK4/6 degraders (PROTACs) containing a phosphoroorganic warhead (POWERTAP)

Call: SONATA 20 , Panel: NZ3

Principal investigator: dr Agnieszka Łupicka-Słowik

Politechnika Wrocławska

FA-PROTACs - Design and Synthesis of Compounds Based on Folic Acid for Degradation of Enzyme Involved in Folate Metaboli...

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Mateusz Daśko

Politechnika Gdańska

Targeting Proteinopathies: Understanding and Mitigating the Effects of Pathogenic Mutations in Cullin-RING Ubiquitin Lig...

Call: OPUS 27 , Panel: NZ3

Principal investigator: dr hab. Wojciech Mieczysław Pokrzywa

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

PROteolysis TArgeting Chimeras (PROTACs) intended to knock down excessive amyloidogenic proteins, human islet amyloid po...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Elżbieta Jankowska

Uniwersytet Gdański, Wydział Chemii

A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

Call: OPUS 24 (LAP) , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński, Collegium Medicum

Impact of the CDK4/6 targeted degradation by PROTACs on immune checkpoint signaling in cancer

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Anna Agnieszka Marusiak

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Application of PROTAC strategy for controlling Rab geranylgeranyl transferase and Rab proteins

Call: PRELUDIUM BIS 2 , Panel: ST4

Principal investigator: dr hab. Katarzyna Magdalena Błażewska

Politechnika Łódzka, Wydział Chemiczny

Targeted degradation of Rab geranylgeranyl transferase as a new approach to investigate prenylation of Rab GTPases

Call: PRELUDIUM BIS 2 , Panel: NZ1

Principal investigator: dr hab. Edyta Violetta Gendaszewska-Darmach

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności