Projects funded by the NCN
Oncogene competition - a new interplay mechanism of mutant p53 with CMYC and mutant KRAS in human cancers.
2022/45/B/NZ5/04189
Keywords:
neoplasia mutant p53 KRAS CMYC transcriptomics organoids xenografts therapy
Descriptors:
- NZ5_003:
- NZ2_002:
- NZ3_001:
Panel:
NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution :
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN
woj. mazowieckie
Principal investigator (from the host institution):
dr hab. Dawid Włodzimierz Walerych
Number of co-investigators in the project: 8
Call: OPUS 23 - announced on 2022-03-28
Amount awarded: 3 369 440 PLN
Project start date (Y-m-d): 2023-03-01
Project end date (Y-m-d): 2027-02-28
Project duration:: 48 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancerAuthors:Maria Grześ, Akanksha Jaiswar, Marcin Grochowski, Weronika Wojtyś, Wojciech Kaźmierczak, Tomasz Olesiński, Małgorzata Lenarcik, Magdalena Nowak-Niezgoda, Małgorzata Kołos, Giulia Canarutto, Silvano Piazza, Jacek R Wiśniewski , Dawid WalerychAcademic press:Cell Death and Disease (rok: 2024, tom: 15(8), strony: 638), Wydawca: Springer NatureStatus:PublishedDOI:10.1038/s41419-024-06965-3 - link to the publication