Projects funded by the NCN
Thermodynamics of modified RNAs. Impact of RNA modifications on structure and function of natural RNA and vaccine-type in vitro transcribed mRNA (IVT mRNA).
2022/45/B/ST4/03586
Keywords:
RNA structure thermodynamics of RNA pseudouridine N1-methylpseudouridine chemical mapping of RNA structure IVT mRNA vaccines nanopore RNA sequencing
Descriptors:
- ST4_009:
- ST4_003:
- NZ1_004:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
woj. wielkopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 6
Call: OPUS 23 - announced on 2022-03-28
Amount awarded: 2 685 220 PLN
Project start date (Y-m-d): 2023-03-01
Project end date (Y-m-d): 2027-02-28
Project duration:: 48 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Targeting sgRNA N secondary structure as a way of inhibiting SARS-CoV-2 replication.Authors:A. Baliga-Gil, M. Soszynska-Jozwiak, A. Ruszkowska, I. Szczesniak, R. Kierzek, M. Ciechanowska, M. Trybus, P. Jackowiak, J.M. Peterson, W.N. Moss, E. KierzekAcademic press:Antiviral Research (rok: 2024, tom: 228, strony: 105946), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.antiviral.2024.105946 - link to the publication