Evaluation of NOTCH1- and NOTCH3-dependent anticancer drug resistance in a 2D an

Evaluation of NOTCH1- and NOTCH3-dependent anticancer drug resistance in a 2D and 3D model of Head and Neck Squamous Cell Carcinoma (HNSCC)

2021/41/N/NZ5/01938

Keywords

Descriptors

NZ1_001: Biologia molekularna
NZ5_007: Leczenie chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny w Lublinie

Voivodeship: lubelskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Joanna Elżbieta Kałafut

Number of co-investigators in the project: 2

Call

PRELUDIUM 20 – announced on 2021-03-15

Amount awarded: 209 150 PLN
Project start date: 2022-03-01
Project end date: 2025-10-31
Project duration: 44 months (the same as in the proposal)
Project status: Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (4)

Evaluation of the anticancer activity of RIN-1, a Notch signaling modulator, in head and neck squamous cell carcinoma

Authors:
Czerwonka A, Kałafut J, Wang S, Anameric A, Przybyszewska-Podstawka A, Mattsson J, Karbasian M, Le Manach D, Toriseva M, Nees M.

Academic press:
Scientific Reports (year: 2023, volume: 22;13(1), pages: 13700), Publisher: Nature Research

Status:
Published

DOI:
10.1038/s41598-023-39472-0 – link to the publication
Modulation of Notch Signaling by Small-Molecular Compounds and Its Potential in Anticancer Studies

Authors:
Czerwonka, A.; Kałafut, J.; Nees, M

Academic press:
Cancers (year: 2023, volume: 15, pages: 4563), Publisher: MDPI

Status:
Published

DOI:
10.3390/cancers15184563 – link to the publication
The Notch inhibitor, FLI-06, increases the chemosensitivity of head and neck Squamous cell carcinoma cells to taxanes-based treatment

Authors:
Arkadiusz Czerwonka, Joanna Kalafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Mervi Toriseva, Matthias Nees

Academic press:
Biomedicine & Pharmacotherapy (year: 2024, volume: 177, pages: 116822), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.biopha.2024.116822 – link to the publication
Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders

Authors:
Kałafut J, Czerwonka A, Czapla K, Przybyszewska-Podstawka A, Hermanowicz JM, Rivero-Müller A, Borkiewicz L

Academic press:
International Journal of Molecular Sciences (year: 2023, volume: 24, pages: 12579), Publisher: MDPI

Status:
Published

DOI:
10.3390/ijms241612579 – link to the publication

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