Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Evaluation of NOTCH1- and NOTCH3-dependent anticancer drug resistance in a 2D and 3D model of Head and Neck Squamous Cell Carcinoma (HNSCC)

2021/41/N/NZ5/01938

Keywords:

NOTCH signalling chemoresistance optogenetics CRISPR/Cas9 cancer

Descriptors:

  • NZ1_001:
  • NZ5_007:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Lublinie

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Elżbieta Kałafut 

Number of co-investigators in the project: 2

Call: PRELUDIUM 20 - announced on 2021-03-15

Amount awarded: 209 150 PLN

Project start date (Y-m-d): 2022-03-01

Project end date (Y-m-d): 2026-02-28

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Modulation of Notch Signaling by Small-Molecular Compounds and Its Potential in Anticancer Studies
    Authors:
    Czerwonka, A.; Kałafut, J.; Nees, M
    Academic press:
    Cancers (rok: 2023, tom: 15, strony: 4563), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15184563 - link to the publication
  2. Evaluation of the anticancer activity of RIN-1, a Notch signaling modulator, in head and neck squamous cell carcinoma
    Authors:
    Czerwonka A, Kałafut J, Wang S, Anameric A, Przybyszewska-Podstawka A, Mattsson J, Karbasian M, Le Manach D, Toriseva M, Nees M.
    Academic press:
    Scientific Reports (rok: 2023, tom: 22;13(1), strony: 13700), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-023-39472-0 - link to the publication
  3. The Notch inhibitor, FLI-06, increases the chemosensitivity of head and neck Squamous cell carcinoma cells to taxanes-based treatment
    Authors:
    Arkadiusz Czerwonka, Joanna Kalafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Mervi Toriseva, Matthias Nees
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2024, tom: 177, strony: 116822), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2024.116822 - link to the publication
  4. Regulation of Notch1 Signalling by Long Non-Coding RNAs in Cancers and Other Health Disorders
    Authors:
    Kałafut J, Czerwonka A, Czapla K, Przybyszewska-Podstawka A, Hermanowicz JM, Rivero-Müller A, Borkiewicz L
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 12579), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms241612579 - link to the publication

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