Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Novel therapy for pulmonary hypertension with dual mechanism of action: Myo-inositol trispyrophosphate targeting both pulmonary vessels and the heart

2019/35/B/NZ5/04432

Keywords:

pulmonary hypertension,

Descriptors:

  • NZ5_003:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Medyczne Kształcenia Podyplomowego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Michał Maria Mączewski 

Number of co-investigators in the project: 8

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 2 050 716 PLN

Project start date (Y-m-d): 2020-07-20

Project end date (Y-m-d): 2024-07-19

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Myo‐inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline‐induced pulmonary hypertension in the rat
    Authors:
    Marta Oknińska, Aleksandra Paterek, Małgorzata Grzanka, Karolina Zajda, Michał Mączewski
    Academic press:
    British Journal of Pharmacology (rok: 2024, tom: In Press, strony: 45674), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/bph.16482 - link to the publication
  2. Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate
    Authors:
    Marta Oknińska, Zuzanna Zambrowska, Karolina Zajda, Aleksandra Paterek, Klaudia Brodaczewska, Urszula Mackiewicz, Cezary Szczylik, Adam Torbicki, Claudine Kieda & Michał Mączewski
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 18002), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-97470-6 - link to the publication
  3. New potential treatment for cardiovascular disease through modulation of hemoglobin oxygen binding curve: Myo-inositol trispyrophosphate (ITPP), from cancer to cardiovascular disease
    Authors:
    Marta Oknińska, Urszula Mackiewicz, Karolina Zajda, Claudine Kieda, Michał Mączewski
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2022, tom: 154, strony: 113544), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2022.113544 - link to the publication
  4. Role of oxygen starvation in right ventricular decompensation/failure in pulmonary arterial hypertension
    Authors:
    Marta Oknińska, Karolina Zajda, Zuzanna Zambrowska, Małgorzata Grzanka, Aleksandra Paterek, Urszula Mackiewicz, Cezary Szczylik, Marcin Kurzyna, Agnieszka Piekiełko-Witkowska, Adam Torbicki, Claudine Kieda, Michał Mączewski
    Status:
    Accepted for publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy