Do potential new MRGPRX2 ligands induce mastocytes degranulation in human?

2019/35/B/NZ5/02398

Keywords

Descriptors

  • NZ5_003: Patogeneza chorób człowieka
  • NZ5_005: Diagnostyka chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński, Collegium Medicum

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Grzegorz Porębski

Number of co-investigators in the project: 4

Call

OPUS 18 – announced on 2019-09-16

Amount awarded
564 360 PLN
Project start date
2020-09-15
Project end date
2026-09-14
Project duration
72 months (the same as in the proposal)
Project status
Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

  1. Mast cell degranulation and bradykinin-induced angioedema - searching for the missing link.

    Authors:
    Porebski G, Dziadowiec A, Rybka H, Kitel R, Kwitniewski M
    Academic press:
    Frontiers in Immunology (year: 2024, volume: 15, pages: 1399459), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1399459 – link to the publication
  2. Modulation of the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) by Xenobiotic Compounds and Its Relevance to Human Diseases.

    Authors:
    Dziadowiec A, Popiolek I, Kwitniewski M, Porebski G.
    Academic press:
    Journal of Xenobiotics (year: 2024, volume: 14(1), pages: 380-403), Publisher: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/jox14010024 – link to the publication

Articles in post-conference publications (2)

  1. Mast cell activation test for the diagnosis of rocuronium-induced perioperative hypersensitivity reactions

    Authors:
    Grzegorz Porebski, Peter Kopac, Alicja Dziadowiec, Ana Koren, Mateusz Kwitniewski
    Conference:
    Alergologia Polska - Polish Journal of Allergology, 2024; 11, 3, suppl 1, S20. (year: 2024, volume: XV Międzynarodowy Kongres Polskiego Towarzystwa Alergologicznego, pages: S20), Publisher: Termedia
    Date:
    conference 9-12 października 2024
    Status:
    Published
    DOI:
    10.5114/pja.2024.144346 – link to the publication
  2. Rola polimorfizmów pojedynczego nukleotydu receptora MRGPRX2 w reakcjach nadwrażliwości natychmiastowej na fluorochinolony i leki zwiotczające

    Authors:
    ALICJA DZIADOWIEC, MATEUSZ KWITNIEWSKI, PETER KOPAC, LENKA SEDLAČKOVÁ, ADRIANA ŠROTOVÁ, JOANNA GLÜCK, GRZEGORZ PORĘBSKI
    Conference:
    XXII Konferencja Naukowo-Szkoleniowa Alergia Astma Immunologia Kliniczna 15-17 czerwca 2023, Łódź (year: 2023, volume: XXII Konferencja Naukowo-Szkoleniowa Alergia Astma Immunologia Kliniczna, pages: 12), Publisher: Stowarzyszenie Pomocy Chorym na Astmę i Choroby Alergiczne
    Date:
    conference 15-17 czerwca 2023
    Status:
    Published
    DOI:
    link to the publication

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